Gene description for MCM9
Gene name minichromosome maintenance complex component 9
Gene symbol MCM9
Other names/aliases C6orf61
MCMDC1
ODG4
dJ329L24.1
dJ329L24.3
Species Homo sapiens
 Database cross references - MCM9
ExoCarta ExoCarta_254394
Entrez Gene 254394
HGNC 21484
MIM 610098
UniProt Q9NXL9  
 MCM9 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for MCM9
Molecular Function
    helicase activity GO:0004386 IEA
    DNA binding GO:0003677 IEA
    ATP binding GO:0005524 IEA
Biological Process
    double-strand break repair via homologous recombination GO:0000724 IDA
    female gamete generation GO:0007292 ISS
    DNA replication GO:0006260 IEA
    cellular response to DNA damage stimulus GO:0006974 IDA
Subcellular Localization
    nucleus GO:0005634 IEA
    MCM8-MCM9 complex GO:0097362 IDA
 Experiment description of studies that identified MCM9 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MCM9
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MCM9 is involved
No pathways found





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