Gene description for MCM9
Gene name minichromosome maintenance complex component 9
Gene symbol MCM9
Other names/aliases C6orf61
MCMDC1
ODG4
dJ329L24.1
dJ329L24.3
Species Homo sapiens
 Database cross references - MCM9
ExoCarta ExoCarta_254394
Vesiclepedia VP_254394
Entrez Gene 254394
HGNC 21484
MIM 610098
UniProt Q9NXL9  
 MCM9 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for MCM9
Molecular Function
    DNA helicase activity GO:0003678 IMP
    chromatin binding GO:0003682 IDA
    DNA clamp loader activity GO:0003689 IEA
    single-stranded DNA binding GO:0003697 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    four-way junction helicase activity GO:0009378 IEA
    ATP hydrolysis activity GO:0016887 IEA
    single-stranded DNA helicase activity GO:0017116 IBA
    enzyme binding GO:0019899 IPI
    MutLbeta complex binding GO:0032406 IDA
    MutSalpha complex binding GO:0032407 IDA
    MutSbeta complex binding GO:0032408 IDA
    double-stranded DNA helicase activity GO:0036121 IEA
    protein-containing complex binding GO:0044877 IDA
    forked DNA-dependent helicase activity GO:0061749 IEA
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
    single-stranded 3'-5' DNA helicase activity GO:1990518 IEA
Biological Process
    double-strand break repair via homologous recombination GO:0000724 IBA
    double-strand break repair via homologous recombination GO:0000724 IDA
    double-strand break repair via homologous recombination GO:0000724 IMP
    double-strand break repair via homologous recombination GO:0000724 NAS
    DNA replication GO:0006260 IGI
    chromatin remodeling GO:0006338 IEA
    DNA damage response GO:0006974 IDA
    female gamete generation GO:0007292 ISS
    DNA duplex unwinding GO:0032508 IDA
    DNA duplex unwinding GO:0032508 IMP
    recombinational interstrand cross-link repair GO:0036298 IMP
    mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication GO:0070716 IMP
    mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication GO:0070716 NAS
    protein localization to chromatin GO:0071168 IMP
    chromatin looping GO:0140588 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    chromosome GO:0005694 IEA
    MCM complex GO:0042555 IBA
    MCM8-MCM9 complex GO:0097362 IDA
    MCM8-MCM9 complex GO:0097362 IPI
 Experiment description of studies that identified MCM9 in exosomes
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MCM9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MESDC2 23184
Two-hybrid Homo sapiens
2 MCMBP 79892
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
3 MCM8 84515
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 FASN 2194
Negative Genetic Homo sapiens
5 CHIC1  
Affinity Capture-MS Homo sapiens
6 WFDC11  
Affinity Capture-MS Homo sapiens
7 FAF2 23197
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 HORMAD2  
Affinity Capture-MS Homo sapiens
9 MSH6 2956
Affinity Capture-MS Homo sapiens
10 MSH2 4436
Affinity Capture-MS Homo sapiens
11 SSR2  
Affinity Capture-MS Homo sapiens
12 MCM9 254394
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
13 MCM5 4174
Affinity Capture-MS Homo sapiens
14 NF2 4771
Negative Genetic Homo sapiens
15 PLAUR 5329
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TP53BP1 7158
Negative Genetic Homo sapiens
17 NELFA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 MLH1 4292
Affinity Capture-MS Homo sapiens
19 CAND1 55832
Affinity Capture-MS Homo sapiens
20 VWA5A 4013
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 VHL  
Negative Genetic Homo sapiens
22 GIGYF2 26058
Cross-Linking-MS (XL-MS) Homo sapiens
23 SREBF2 6721
Positive Genetic Homo sapiens
24 HNRNPLL 92906
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 MTOR 2475
Cross-Linking-MS (XL-MS) Homo sapiens
26 PNMA2  
Affinity Capture-MS Homo sapiens
27 THBS3 7059
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 STK11 6794
Negative Genetic Homo sapiens
29 HECTD1 25831
Affinity Capture-MS Homo sapiens
30 PSG8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 C17orf53  
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which MCM9 is involved
No pathways found





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