Gene description for MSH2
Gene name	mutS homolog 2
Gene symbol	MSH2
Other names/aliases	COCA1 FCC1 HNPCC HNPCC1 LCFS2
Species	Homo sapiens
Database cross references - MSH2
ExoCarta	ExoCarta_4436
Entrez Gene	4436
HGNC	7325
MIM	609309
UniProt	P43246
MSH2 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Squamous carcinoma cells	20124223
Thymus	23844026

Gene ontology annotations for MSH2

Molecular Function     MutLalpha complex binding GO:0032405 IDA     DNA-dependent ATPase activity GO:0008094 IBA     DNA binding GO:0003677 IDA     oxidized purine DNA binding GO:0032357 IDA     four-way junction DNA binding GO:0000400 IDA     ATP binding GO:0005524 IDA     protein kinase binding GO:0019901 IPI     protein C-terminus binding GO:0008022 IPI     dinucleotide repeat insertion binding GO:0032181 IDA     enzyme binding GO:0019899 IPI     double-strand/single-strand DNA junction binding GO:0000406 IBA     ADP binding GO:0043531 IDA     Y-form DNA binding GO:0000403 IBA     single thymine insertion binding GO:0032143 IDA     single guanine insertion binding GO:0032142 IDA     single-stranded DNA binding GO:0003697 IDA     centromeric DNA binding GO:0019237 IEA     magnesium ion binding GO:0000287 IDA     double-stranded DNA binding GO:0003690 IDA     guanine/thymine mispair binding GO:0032137 IMP     protein binding GO:0005515 IPI     dinucleotide insertion or deletion binding GO:0032139 IDA     heteroduplex DNA loop binding GO:0000404 IBA     ATPase activity GO:0016887 IDA     protein homodimerization activity GO:0042803 IDA     mismatched DNA binding GO:0030983 IDA Biological Process     somatic hypermutation of immunoglobulin genes GO:0016446 IBA     determination of adult lifespan GO:0008340 IEA     maintenance of DNA repeat elements GO:0043570 IMP     postreplication repair GO:0006301 IDA     intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 IBA     intra-S DNA damage checkpoint GO:0031573 IBA     male gonad development GO:0008584 ISS     negative regulation of neuron apoptotic process GO:0043524 ISS     mismatch repair GO:0006298 TAS     B cell mediated immunity GO:0019724 ISS     meiotic gene conversion GO:0006311 IBA     positive regulation of helicase activity GO:0051096 IDA     negative regulation of DNA recombination GO:0045910 ISS     meiotic mismatch repair GO:0000710 IBA     negative regulation of reciprocal meiotic recombination GO:0045128 IBA     response to UV-B GO:0010224 ISS     isotype switching GO:0045190 ISS     in utero embryonic development GO:0001701 IEA     B cell differentiation GO:0030183 ISS     somatic recombination of immunoglobulin gene segments GO:0016447 ISS     germ cell development GO:0007281 IEA     reciprocal meiotic recombination GO:0007131 IBA     double-strand break repair GO:0006302 IBA     DNA repair GO:0006281 TAS     cell cycle arrest GO:0007050 IEA     oxidative phosphorylation GO:0006119 IEA     response to X-ray GO:0010165 ISS Subcellular Localization     MutSalpha complex GO:0032301 IDA     nucleoplasm GO:0005654 TAS     membrane GO:0016020 IDA     MutSbeta complex GO:0032302 IDA     nuclear chromosome GO:0000228 IBA