Gene description for ALDH1L1
Gene name aldehyde dehydrogenase 1 family, member L1
Gene symbol ALDH1L1
Other names/aliases 10-FTHFDH
10-fTHF
FDH
FTHFD
Species Homo sapiens
 Database cross references - ALDH1L1
ExoCarta ExoCarta_10840
Entrez Gene 10840
HGNC 3978
MIM 600249
UniProt O75891  
 ALDH1L1 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ALDH1L1
Molecular Function
    hydroxymethyl-, formyl- and related transferase activity GO:0016742 IEA
    catalytic activity GO:0003824 TAS
    aldehyde dehydrogenase (NAD) activity GO:0004029 IBA
    methyltransferase activity GO:0008168 IEA
    formyltetrahydrofolate dehydrogenase activity GO:0016155 IBA
Biological Process
    10-formyltetrahydrofolate catabolic process GO:0009258 IEA
    oxidation-reduction process GO:0055114 IEA
    methylation GO:0032259 IEA
    one-carbon metabolic process GO:0006730 IEA
    biosynthetic process GO:0009058 IEA
Subcellular Localization
    mitochondrion GO:0005739 IEA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified ALDH1L1 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ALDH1L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ALDH1L1 is involved
No pathways found





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