Gene description for MRE11A
Gene name	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Gene symbol	MRE11A
Other names/aliases	ATLD HNGS1 MRE11 MRE11B
Species	Homo sapiens
Database cross references - MRE11A
ExoCarta	ExoCarta_4361
Entrez Gene	4361
HGNC	7230
MIM	600814
UniProt	P49959
MRE11A identified in exosomes derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for MRE11A

Molecular Function     double-stranded DNA binding GO:0003690 TAS     protein C-terminus binding GO:0008022 IPI     nuclease activity GO:0004518 TAS     DNA binding GO:0003677 IDA     protein binding GO:0005515 IPI     single-stranded DNA endodeoxyribonuclease activity GO:0000014 IDA     3'-5' exonuclease activity GO:0008408 IDA     manganese ion binding GO:0030145 IEA     endodeoxyribonuclease activity GO:0004520 IDA     ATP-dependent DNA helicase activity GO:0004003 IMP Biological Process     innate immune response GO:0045087 TAS     double-strand break repair via nonhomologous end joining GO:0006303 IDA     synapsis GO:0007129 IEA     cellular response to DNA damage stimulus GO:0006974 IDA     DNA recombination GO:0006310 TAS     regulation of mitotic recombination GO:0000019 TAS     double-strand break repair via homologous recombination GO:0000724 TAS     DNA duplex unwinding GO:0032508 IMP     negative regulation of DNA endoreduplication GO:0032876 IMP     cell proliferation GO:0008283 IEA     base-excision repair GO:0006284 IBA     positive regulation of type I interferon production GO:0032481 TAS     intra-S DNA damage checkpoint GO:0031573 IBA     reciprocal meiotic recombination GO:0007131 TAS     positive regulation of kinase activity GO:0033674 IDA     DNA repair GO:0006281 TAS     positive regulation of protein autophosphorylation GO:0031954 IDA     nucleic acid phosphodiester bond hydrolysis GO:0090305 TAS     viral process GO:0016032 IEA     telomere maintenance via telomerase GO:0007004 TAS     double-strand break repair GO:0006302 TAS     mitotic G2 DNA damage checkpoint GO:0007095 IEA     sister chromatid cohesion GO:0007062 IMP Subcellular Localization     site of double-strand break GO:0035861 IDA     chromosome, telomeric region GO:0000781 IDA     chromatin GO:0000785 IBA     nucleus GO:0005634 TAS     cytosol GO:0005829 TAS     nucleoplasm GO:0005654 TAS     Mre11 complex GO:0030870 NAS