Gene description for MRE11A
Gene name MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Gene symbol MRE11A
Other names/aliases ATLD
HNGS1
MRE11
MRE11B
Species Homo sapiens
 Database cross references - MRE11A
ExoCarta ExoCarta_4361
Vesiclepedia VP_4361
Entrez Gene 4361
HGNC 7230
MIM 600814
UniProt P49959  
 MRE11A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 36706192    
Embryonic kidney cells 36706192    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Thymus 23844026    
 Gene ontology annotations for MRE11A
Molecular Function
    single-stranded DNA endodeoxyribonuclease activity GO:0000014 IBA
    single-stranded DNA endodeoxyribonuclease activity GO:0000014 IDA
    DNA binding GO:0003677 IDA
    DNA helicase activity GO:0003678 IMP
    double-stranded DNA binding GO:0003690 TAS
    nuclease activity GO:0004518 TAS
    DNA endonuclease activity GO:0004520 IDA
    DNA endonuclease activity GO:0004520 IMP
    DNA endonuclease activity GO:0004520 TAS
    protein binding GO:0005515 IPI
    3'-5'-DNA exonuclease activity GO:0008296 IDA
    3'-5' exonuclease activity GO:0008408 IDA
    manganese ion binding GO:0030145 IEA
    identical protein binding GO:0042802 IPI
    cadherin binding GO:0045296 HDA
Biological Process
    regulation of mitotic recombination GO:0000019 TAS
    telomere maintenance GO:0000723 IBA
    double-strand break repair via homologous recombination GO:0000724 IBA
    double-strand break repair via homologous recombination GO:0000724 IDA
    DNA double-strand break processing GO:0000729 IMP
    DNA double-strand break processing GO:0000729 NAS
    DNA double-strand break processing GO:0000729 TAS
    DNA repair GO:0006281 TAS
    double-strand break repair GO:0006302 IDA
    double-strand break repair via nonhomologous end joining GO:0006303 IBA
    double-strand break repair via nonhomologous end joining GO:0006303 IDA
    DNA recombination GO:0006310 TAS
    DNA damage response GO:0006974 IDA
    DNA damage response GO:0006974 IDA
    telomere maintenance via telomerase GO:0007004 TAS
    sister chromatid cohesion GO:0007062 IMP
    mitotic G2 DNA damage checkpoint signaling GO:0007095 IBA
    homologous chromosome pairing at meiosis GO:0007129 IEA
    reciprocal meiotic recombination GO:0007131 TAS
    cell population proliferation GO:0008283 IEA
    mitotic intra-S DNA damage checkpoint signaling GO:0031573 IBA
    telomeric 3' overhang formation GO:0031860 IMP
    positive regulation of protein autophosphorylation GO:0031954 IDA
    positive regulation of telomere maintenance GO:0032206 IMP
    DNA duplex unwinding GO:0032508 IMP
    positive regulation of kinase activity GO:0033674 IDA
    homologous recombination GO:0035825 NAS
    meiotic DNA double-strand break formation GO:0042138 IBA
    negative regulation of apoptotic process GO:0043066 IMP
    mitotic G2/M transition checkpoint GO:0044818 NAS
    R-loop processing GO:0062176 IDA
    mitochondrial double-strand break repair via homologous recombination GO:0097552 IBA
    DNA strand resection involved in replication fork processing GO:0110025 IDA
    DNA strand resection involved in replication fork processing GO:0110025 NAS
    negative regulation of double-strand break repair via nonhomologous end joining GO:2001033 IDA
Subcellular Localization
    chromosome, telomeric region GO:0000781 HDA
    chromosome, telomeric region GO:0000781 IDA
    chromosome, telomeric region GO:0000781 IDA
    chromosome, telomeric region GO:0000781 ISS
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    replication fork GO:0005657 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    PML body GO:0016605 IDA
    PML body GO:0016605 ISS
    Mre11 complex GO:0030870 IBA
    Mre11 complex GO:0030870 IDA
    Mre11 complex GO:0030870 IPI
    Mre11 complex GO:0030870 NAS
    Mre11 complex GO:0030870 TAS
    site of double-strand break GO:0035861 IBA
    site of double-strand break GO:0035861 IDA
    site of double-strand break GO:0035861 IDA
    BRCA1-C complex GO:0070533 IPI
    chromosomal region GO:0098687 NAS
 Experiment description of studies that identified MRE11A in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 498
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 1275
MISEV standards
Biophysical techniques
✔ Enriched markers
✔ Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 1280
MISEV standards
Biophysical techniques
✔ Enriched markers
✔ Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T - Fraction 5
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density 1.151 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
19
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
21
Experiment ID 217
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MRE11A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AIDA 64853
Co-fractionation Homo sapiens
2 ATR  
Protein-peptide Homo sapiens
3 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
4 LOX 4015
Reconstituted Complex Homo sapiens
5 SENP3 26168
Affinity Capture-MS Homo sapiens
6 RPL26L1 51121
Co-fractionation Homo sapiens
7 SPRTN  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
8 QARS 5859
Co-fractionation Homo sapiens
9 PAXIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
10 MSH6 2956
Co-purification Homo sapiens
11 PCF11 51585
Co-fractionation Homo sapiens
12 TRRAP 8295
Affinity Capture-Western Homo sapiens
13 SQSTM1 8878
Proximity Label-MS Homo sapiens
14 RPA2 6118
Affinity Capture-MS Homo sapiens
15 EIF2B2 8892
Co-fractionation Homo sapiens
16 TRIM66  
Affinity Capture-MS Homo sapiens
17 ABCF1 23
Co-fractionation Homo sapiens
18 GAK 2580
Affinity Capture-MS Homo sapiens
19 BRCA1 672
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
20 NUMA1 4926
Affinity Capture-MS Homo sapiens
21 UBC 7316
Affinity Capture-MS Homo sapiens
22 MRE11A 4361
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 KIF5B 3799
Co-fractionation Homo sapiens
24 TERF2IP 54386
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
25 NLRP2  
Affinity Capture-Western Homo sapiens
26 PRKDC 5591
Protein-peptide Homo sapiens
27 Tubgcp6  
Affinity Capture-MS Mus musculus
28 ILF2 3608
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
29 IGF2BP3 10643
Co-fractionation Homo sapiens
30 TRIM28 10155
Affinity Capture-MS Homo sapiens
31 PELI1 57162
Affinity Capture-Western Homo sapiens
32 MCM2 4171
Synthetic Growth Defect Homo sapiens
33 GNS 2799
Co-fractionation Homo sapiens
34 RNF8  
Affinity Capture-Western Homo sapiens
35 ESRRG  
Affinity Capture-MS Homo sapiens
36 LIG1 3978
Two-hybrid Homo sapiens
37 FBXW7  
Affinity Capture-MS Homo sapiens
38 PRC1 9055
Affinity Capture-MS Homo sapiens
39 MDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
40 POU5F1  
Affinity Capture-MS Homo sapiens
41 BRPF3  
Affinity Capture-MS Homo sapiens
42 USP4 7375
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
43 OBSL1 23363
Affinity Capture-MS Homo sapiens
44 TINF2  
Affinity Capture-MS Homo sapiens
45 EXD2  
Affinity Capture-Western Homo sapiens
46 EED  
Affinity Capture-MS Homo sapiens
47 NMT1 4836
Co-fractionation Homo sapiens
48 FEN1 2237
Co-fractionation Homo sapiens
Synthetic Lethality Homo sapiens
49 FOXP1 27086
Affinity Capture-MS Homo sapiens
50 RPL27 6155
Co-fractionation Homo sapiens
51 GNG8  
Affinity Capture-MS Homo sapiens
52 BRIP1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
53 SPTA1  
Affinity Capture-Western Homo sapiens
54 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
55 PPIH 10465
Co-fractionation Homo sapiens
56 USP11 8237
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 PARK2  
Affinity Capture-MS Homo sapiens
58 SCG3  
Affinity Capture-MS Homo sapiens
59 HSP90B1 7184
Co-fractionation Homo sapiens
60 BLM 641
Co-purification Homo sapiens
61 NBN 4683
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
62 ATF2  
Co-localization Homo sapiens
63 HIST1H3E 8353
Affinity Capture-MS Homo sapiens
64 RAB43 339122
Affinity Capture-MS Homo sapiens
65 GCC2 9648
Co-fractionation Homo sapiens
66 CDH1 999
Proximity Label-MS Homo sapiens
67 PYHIN1  
Affinity Capture-MS Homo sapiens
68 LRRFIP1 9208
Co-fractionation Homo sapiens
69 BARD1 580
Affinity Capture-Western Homo sapiens
70 SLX4  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
71 AIM2  
Affinity Capture-MS Homo sapiens
72 U2AF2 11338
Co-fractionation Homo sapiens
73 RGS20 8601
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 SUMO2 6613
Reconstituted Complex Homo sapiens
75 C15orf26  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 RPA4  
Proximity Label-MS Homo sapiens
77 CELA2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 RFC4 5984
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
79 DDX1 1653
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
80 DHX9 1660
Co-fractionation Homo sapiens
81 DCLRE1B  
Affinity Capture-Western Homo sapiens
82 ATRX 546
Affinity Capture-MS Homo sapiens
83 NECAP1 25977
Affinity Capture-MS Homo sapiens
84 H2AFX 3014
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
85 CEBPA  
Protein-peptide Homo sapiens
86 SMARCC2 6601
Co-fractionation Homo sapiens
87 PHLPP1  
Proximity Label-MS Homo sapiens
88 BIRC2  
Affinity Capture-Western Homo sapiens
89 RECQL5  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
90 TMPO 7112
Co-fractionation Homo sapiens
91 MAP7 9053
Co-fractionation Homo sapiens
92 FANCD2  
Affinity Capture-MS Homo sapiens
93 CUL3 8452
Affinity Capture-MS Homo sapiens
94 MSH2 4436
Co-fractionation Homo sapiens
Co-purification Homo sapiens
95 CIAO1 9391
Affinity Capture-MS Homo sapiens
96 TPR 7175
Co-fractionation Homo sapiens
97 NTRK1 4914
Affinity Capture-MS Homo sapiens
98 SIRT7  
Affinity Capture-MS Homo sapiens
99 CD6 923
Affinity Capture-MS Homo sapiens
100 SKP2  
Affinity Capture-Western Homo sapiens
101 RAD18  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
102 CCNE1  
Affinity Capture-Western Homo sapiens
103 GATA3  
Affinity Capture-MS Homo sapiens
104 ATM 472
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
105 GLI1  
Affinity Capture-MS Homo sapiens
106 DCLRE1C  
Affinity Capture-Western Homo sapiens
107 EIF2B3 8891
Co-fractionation Homo sapiens
108 MDM4  
Affinity Capture-Western Homo sapiens
109 HIST3H3 8290
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
110 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
111 RFC1 5981
Co-fractionation Homo sapiens
Co-purification Homo sapiens
112 HOOK3 84376
Co-fractionation Homo sapiens
113 FASN 2194
Negative Genetic Homo sapiens
114 PCBP1 5093
Proximity Label-MS Homo sapiens
115 RPA3 6119
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
116 KAT5  
Affinity Capture-Western Homo sapiens
117 CDC45  
Synthetic Growth Defect Homo sapiens
118 ATRIP  
Affinity Capture-Western Homo sapiens
119 PCGF1 84759
Affinity Capture-MS Homo sapiens
120 CUL7 9820
Affinity Capture-MS Homo sapiens
121 FLII 2314
Co-fractionation Homo sapiens
122 PARP1 142
Co-fractionation Homo sapiens
123 BMP1 649
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 NANOG  
Affinity Capture-MS Homo sapiens
125 NELFB 25920
Co-fractionation Homo sapiens
126 NFATC2  
Affinity Capture-MS Homo sapiens
127 MDM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
128 XRCC5 7520
Co-fractionation Homo sapiens
129 HUWE1 10075
Affinity Capture-MS Homo sapiens
130 RBBP8  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
131 TACC3  
Co-fractionation Homo sapiens
132 DRC1  
Co-fractionation Homo sapiens
133 NUDT21 11051
Co-fractionation Homo sapiens
134 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
135 FBXW11  
Affinity Capture-MS Homo sapiens
136 SPOP  
Two-hybrid Homo sapiens
137 TERF2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
138 PRKY  
Affinity Capture-MS Homo sapiens
139 FBXL6  
Proximity Label-MS Homo sapiens
140 TP53 7157
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 MLH1 4292
Co-fractionation Homo sapiens
Co-purification Homo sapiens
142 GINS1  
Synthetic Growth Defect Homo sapiens
143 SMARCC1 6599
Co-fractionation Homo sapiens
144 RPA1 6117
Affinity Capture-MS Homo sapiens
145 HNRNPA2B1 3181
Co-fractionation Homo sapiens
146 HMGN5 79366
Affinity Capture-MS Homo sapiens
147 HNRNPM 4670
Co-fractionation Homo sapiens
148 PTBP1 5725
Co-fractionation Homo sapiens
149 MAGEL2  
Proximity Label-MS Homo sapiens
150 RAB32 10981
Affinity Capture-MS Homo sapiens
151 TDRD7 23424
Affinity Capture-MS Homo sapiens
152 MKI67  
Affinity Capture-MS Homo sapiens
153 NEK1  
Two-hybrid Homo sapiens
154 RAD50 10111
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-Western Homo sapiens
155 UFL1 23376
Affinity Capture-MS Homo sapiens
156 ERCC3  
Co-fractionation Homo sapiens
157 FAM219A 203259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
158 ERCC6  
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
159 DHX16 8449
Co-fractionation Homo sapiens
160 RTCB 51493
Co-fractionation Homo sapiens
161 YBX3 8531
Co-fractionation Homo sapiens
162 PINK1  
Affinity Capture-MS Homo sapiens
163 C14orf166 51637
Co-fractionation Homo sapiens
164 BRD1 23774
Affinity Capture-MS Homo sapiens
165 POLA1  
Synthetic Growth Defect Homo sapiens
166 XRCC6 2547
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
167 SNW1 22938
Affinity Capture-MS Homo sapiens
168 HNRNPU 3192
Co-fractionation Homo sapiens
169 CHAMP1  
Co-fractionation Homo sapiens
170 NUCKS1 64710
Affinity Capture-MS Homo sapiens
171 PTCH1  
Affinity Capture-MS Homo sapiens
172 CCT8L2  
Affinity Capture-MS Homo sapiens
173 PRMT1 3276
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
174 AK1 203
Affinity Capture-MS Homo sapiens
175 EP300 2033
Affinity Capture-MS Homo sapiens
176 CDC5L 988
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MRE11A is involved
PathwayEvidenceSource
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Cytosolic sensors of pathogen-associated DNA TAS Reactome
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function TAS Reactome
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function TAS Reactome
Defective homologous recombination repair (HRR) due to BRCA1 loss of function TAS Reactome
Defective homologous recombination repair (HRR) due to BRCA2 loss of function TAS Reactome
Defective homologous recombination repair (HRR) due to PALB2 loss of function TAS Reactome
Disease TAS Reactome
Diseases of DNA Double-Strand Break Repair TAS Reactome
Diseases of DNA repair TAS Reactome
DNA Damage/Telomere Stress Induced Senescence TAS Reactome
DNA Double Strand Break Response TAS Reactome
DNA Double-Strand Break Repair TAS Reactome
DNA Repair TAS Reactome
G2/M Checkpoints TAS Reactome
G2/M DNA damage checkpoint TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
HDR through Homologous Recombination (HRR) TAS Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) TAS Reactome
HDR through MMEJ (alt-NHEJ) TAS Reactome
HDR through Single Strand Annealing (SSA) TAS Reactome
Homologous DNA Pairing and Strand Exchange TAS Reactome
Homology Directed Repair TAS Reactome
Immune System TAS Reactome
Impaired BRCA2 binding to PALB2 TAS Reactome
Impaired BRCA2 binding to RAD51 TAS Reactome
Innate Immune System TAS Reactome
IRF3-mediated induction of type I IFN TAS Reactome
Meiosis IEA Reactome
Meiotic recombination IEA Reactome
Nonhomologous End-Joining (NHEJ) TAS Reactome
Presynaptic phase of homologous DNA pairing and strand exchange TAS Reactome
Processing of DNA double-strand break ends TAS Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TAS Reactome
Regulation of TP53 Activity TAS Reactome
Regulation of TP53 Activity through Phosphorylation TAS Reactome
Reproduction IEA Reactome
Resolution of D-Loop Structures TAS Reactome
Resolution of D-loop Structures through Holliday Junction Intermediates TAS Reactome
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) TAS Reactome
RNA Polymerase II Transcription TAS Reactome
Sensing of DNA Double Strand Breaks TAS Reactome
STING mediated induction of host immune responses TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome





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