Gene description for SMARCC1
Gene name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
Gene symbol SMARCC1
Other names/aliases BAF155
CRACC1
Rsc8
SRG3
SWI3
Species Homo sapiens
 Database cross references - SMARCC1
ExoCarta ExoCarta_6599
Vesiclepedia VP_6599
Entrez Gene 6599
HGNC 11104
MIM 601732
UniProt Q92922  
 SMARCC1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for SMARCC1
Molecular Function
    RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    protein binding GO:0005515 IPI
    protein N-terminus binding GO:0047485 IPI
    nucleosomal DNA binding GO:0031492 IDA
    transcription coactivator activity GO:0003713 NAS
Biological Process
    nervous system development GO:0007399 IEA
    ATP-dependent chromatin remodeling GO:0043044 IDA
    insulin receptor signaling pathway GO:0008286 IEA
    regulation of transcription from RNA polymerase II promoter GO:0006357 NAS
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    nucleosome disassembly GO:0006337 IDA
    chromatin organization GO:0006325 TAS
    organ morphogenesis GO:0009887 IEA
    chromatin remodeling GO:0006338 IDA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    nuclear chromatin GO:0000790 IDA
    nBAF complex GO:0071565 ISS
    XY body GO:0001741 IEA
    npBAF complex GO:0071564 ISS
    protein complex GO:0043234 IDA
    SWI/SNF complex GO:0016514 IDA
 Experiment description of studies that identified SMARCC1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 211
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
EV Enriched markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 212
MISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
EV Enriched markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 217
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|CD81|CD9|CD63
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SMARCC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GATA1  
Reconstituted Complex Homo sapiens
2 SMARCB1 6598
Co-purification Homo sapiens
Co-purification Homo sapiens
3 SMARCA2 6595
Co-purification Homo sapiens
Co-purification Homo sapiens
4 STAT2 6773
Affinity Capture-Western Homo sapiens
5 KLF1  
Reconstituted Complex Homo sapiens
6 SIN3A  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
7 TP53 7157
Co-fractionation Homo sapiens
8 CDK8 1024
Co-fractionation Homo sapiens
9 BAZ1B 9031
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
10 SMARCD1 6602
Affinity Capture-Western Homo sapiens
11 SP1  
Reconstituted Complex Homo sapiens
12 BRCA1 672
Co-purification Homo sapiens
13 SMARCE1 6605
Affinity Capture-Western Homo sapiens
14 NR3C1 2908
Affinity Capture-Western Homo sapiens
15 CCNE1  
Affinity Capture-Western Homo sapiens
16 HSP90B1 7184
Affinity Capture-Western Homo sapiens
17 SMARCA4 6597
Co-purification Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
18 ING1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
19 NCOR1  
Co-purification Homo sapiens
20 RELB  
Affinity Capture-MS Homo sapiens
21 CEBPB  
Affinity Capture-Western Homo sapiens
22 AR 367
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SMARCC1 is involved
PathwayEvidenceSource
RMTs methylate histone arginines TAS Reactome





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