Gene description for Abr
Gene name active BCR-related gene
Gene symbol Abr
Other names/aliases -
Species Mus musculus
 Database cross references - Abr
ExoCarta ExoCarta_109934
Entrez Gene 109934
UniProt Q5SSL4  
 Abr identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Abr
Molecular Function
    Rho guanyl-nucleotide exchange factor activity GO:0005089 IEA
    GTPase activator activity GO:0005096 TAS
    guanyl-nucleotide exchange factor activity GO:0005085 IEA
Biological Process
    response to lipopolysaccharide GO:0032496 IMP
    intracellular signal transduction GO:0035556 IEA
    positive regulation of phagocytosis GO:0050766 IGI
    negative regulation of inflammatory response GO:0050728 IMP
    actin cytoskeleton organization GO:0030036 IGI
    negative regulation of neutrophil degranulation GO:0043314 IGI
    negative regulation of cell migration GO:0030336 IGI
    neuromuscular process controlling balance GO:0050885 IGI
    signal transduction GO:0007165 IEA
    positive regulation of GTPase activity GO:0043547 IGI
    inner ear morphogenesis GO:0042472 IGI
    brain development GO:0007420 IGI
    regulation of Rho protein signal transduction GO:0035023 IEA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    cytosol GO:0005829 IDA
    membrane GO:0016020 ISO
 Experiment description of studies that identified Abr in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Abr
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Abr is involved
PathwayEvidenceSource
G alpha (12/13) signalling events IEA Reactome
NRAGE signals death through JNK IEA Reactome
Rho GTPase cycle IEA Reactome





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