Gene description for SLC15A2
Gene name solute carrier family 15 (oligopeptide transporter), member 2
Gene symbol SLC15A2
Other names/aliases PEPT2
Species Homo sapiens
 Database cross references - SLC15A2
ExoCarta ExoCarta_6565
Vesiclepedia VP_6565
Entrez Gene 6565
HGNC 10921
MIM 602339
UniProt Q16348  
 SLC15A2 identified in exosomes derived from the following tissue/cell type
Pancreatic duct fluid 29339034    
Pancreatic duct fluid 29339034    
Saliva 19199708    
Urine 19056867    
 Gene ontology annotations for SLC15A2
Molecular Function
    dipeptide transporter activity GO:0042936 IEA
    peptide:proton symporter activity GO:0015333 TAS
    high-affinity oligopeptide transporter activity GO:0015334 IEA
    protein binding GO:0005515 IPI
    antibiotic transporter activity GO:0042895 IEA
Biological Process
    drug transport GO:0015893 NAS
    antibiotic transport GO:0042891 IEA
    dipeptide transport GO:0042938 IEA
    protein transport GO:0015031 IEA
    proton transport GO:0015992 TAS
    ion transport GO:0006811 TAS
    transport GO:0006810 TAS
    transmembrane transport GO:0055085 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 TAS
    integral component of plasma membrane GO:0005887 IEA
 Experiment description of studies that identified SLC15A2 in exosomes
1
Experiment ID 622
MISEV standards
✔
EM
EV Biophysical techniques
EV Enriched markers
✔
GOLGA2|CYC1
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 29339034    
Organism Homo sapiens
Experiment description Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer
Authors Zheng J, Hernandez JM, Doussot A, Bojmar L, Zambirinis CP, Costa-Silva B, van Beek EJAH, Mark MT, Molina H, Askan G, Basturk O, Gonen M, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Lyden D, Jarnagin WR.
Journal name HPB
Publication year 2018
Sample Pancreatic duct fluid
Sample name From patients with Pancreatic ductal adenocarcinoma
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 623
MISEV standards
✘ EV Biophysical techniques
EV Enriched markers
✔
GOLGA2|CYC1
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 29339034    
Organism Homo sapiens
Experiment description Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer
Authors Zheng J, Hernandez JM, Doussot A, Bojmar L, Zambirinis CP, Costa-Silva B, van Beek EJAH, Mark MT, Molina H, Askan G, Basturk O, Gonen M, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Lyden D, Jarnagin WR.
Journal name HPB
Publication year 2018
Sample Pancreatic duct fluid
Sample name From patients with IPMN with microinvasive cancer (IPMNca)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 66
MISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix|CD63|CD81
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
4
Experiment ID 63
MISEV standards
✘ EV Biophysical techniques
✔
AQP2
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC15A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC15A2 is involved
PathwayEvidenceSource
Proton/oligonucleotide cotransporters TAS Reactome





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