Gene description for STAT2
Gene name signal transducer and activator of transcription 2, 113kDa
Gene symbol STAT2
Other names/aliases ISGF-3
P113
STAT113
Species Homo sapiens
 Database cross references - STAT2
ExoCarta ExoCarta_6773
Entrez Gene 6773
HGNC 11363
MIM 600556
UniProt P52630  
 STAT2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for STAT2
Molecular Function
    DNA binding GO:0003677 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    signal transducer activity GO:0004871 IEA
Biological Process
    cytokine-mediated signaling pathway GO:0019221 TAS
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    transcription, DNA-templated GO:0006351 IEA
    JAK-STAT cascade GO:0007259 TAS
    defense response to virus GO:0051607 IEA
    regulation of type I interferon-mediated signaling pathway GO:0060338 TAS
    type I interferon signaling pathway GO:0060337 TAS
    positive regulation of defense response to virus by host GO:0002230 IMP
    viral process GO:0016032 IEA
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 TAS
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified STAT2 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for STAT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IFNAR2  
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
2 ISGF3G  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
3 CRSP2  
Invitro Homo sapiens
Invivo Homo sapiens
4 SMARCA4 6597
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 SMARCE1 6605
Affinity Capture-Western Homo sapiens
6 STAT1 6772
Invivo Homo sapiens
Co-purification Homo sapiens
7 IFNAR1  
Invitro Homo sapiens
Invivo Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
8 CREBBP  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
9 SMARCC1 6599
Affinity Capture-Western Homo sapiens
10 EP300 2033
Reconstituted Complex Homo sapiens
11 SMARCC2 6601
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which STAT2 is involved
PathwayEvidenceSource
Interferon alpha/beta signaling TAS Reactome
Regulation of IFNA signaling TAS Reactome





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