Gene description for SMARCD2
Gene name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
Gene symbol SMARCD2
Other names/aliases BAF60B
CRACD2
PRO2451
Rsc6p
Species Homo sapiens
 Database cross references - SMARCD2
ExoCarta ExoCarta_6603
Vesiclepedia VP_6603
Entrez Gene 6603
HGNC 11107
MIM 601736
UniProt Q92925  
 SMARCD2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for SMARCD2
Molecular Function
    transcription coregulator activity GO:0003712 IBA
    transcription coactivator activity GO:0003713 NAS
    protein binding GO:0005515 IPI
    nucleosomal DNA binding GO:0031492 HDA
Biological Process
    nucleosome disassembly GO:0006337 IDA
    chromatin remodeling GO:0006338 HDA
    chromatin remodeling GO:0006338 IDA
    chromatin remodeling GO:0006338 NAS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    regulation of transcription by RNA polymerase II GO:0006357 NAS
    regulation of mitotic metaphase/anaphase transition GO:0030071 NAS
    positive regulation of T cell differentiation GO:0045582 NAS
    positive regulation of cell differentiation GO:0045597 NAS
    positive regulation of myoblast differentiation GO:0045663 NAS
    positive regulation of DNA-templated transcription GO:0045893 IEA
    regulation of G0 to G1 transition GO:0070316 NAS
    regulation of G1/S transition of mitotic cell cycle GO:2000045 NAS
    positive regulation of double-strand break repair GO:2000781 NAS
    regulation of nucleotide-excision repair GO:2000819 NAS
Subcellular Localization
    kinetochore GO:0000776 NAS
    chromatin GO:0000785 HDA
    chromatin GO:0000785 NAS
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nuclear matrix GO:0016363 NAS
    SWI/SNF complex GO:0016514 IBA
    SWI/SNF complex GO:0016514 IDA
    SWI/SNF complex GO:0016514 NAS
    RSC-type complex GO:0016586 NAS
    protein-containing complex GO:0032991 HDA
    brahma complex GO:0035060 NAS
    bBAF complex GO:0140092 NAS
 Experiment description of studies that identified SMARCD2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SMARCD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
2 HNRNPC 3183
Co-fractionation Homo sapiens
3 TEX13A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 FEV  
Proximity Label-MS Homo sapiens
5 BRD9 65980
Affinity Capture-MS Homo sapiens
6 KPNA1 3836
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 TOP2B 7155
Co-fractionation Homo sapiens
8 Bcl7b  
Affinity Capture-MS Mus musculus
9 LHX2  
Proximity Label-MS Homo sapiens
10 NFATC1 4772
Affinity Capture-MS Homo sapiens
11 GATA2  
Proximity Label-MS Homo sapiens
12 ACTC1 70
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 BRCA1 672
Co-purification Homo sapiens
14 SMARCE1 6605
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 BRD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 FAM168A  
Affinity Capture-MS Homo sapiens
17 PPIA 5478
Affinity Capture-MS Homo sapiens
18 KPNA2 3838
Affinity Capture-MS Homo sapiens
19 PTPN1 5770
Affinity Capture-MS Homo sapiens
20 UNKL  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
21 SOX9  
Proximity Label-MS Homo sapiens
22 ELF4 2000
Proximity Label-MS Homo sapiens
23 MYOD1  
Proximity Label-MS Homo sapiens
24 DPF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 NUDCD2 134492
Co-fractionation Homo sapiens
26 PARK2  
Affinity Capture-MS Homo sapiens
27 BCL7B  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
28 PAX6  
Proximity Label-MS Homo sapiens
29 TBL1XR1 79718
Co-fractionation Homo sapiens
30 NUP153 9972
Affinity Capture-MS Homo sapiens
31 MDC1  
Co-fractionation Homo sapiens
32 ETV4  
Proximity Label-MS Homo sapiens
33 GCM1  
Proximity Label-MS Homo sapiens
34 BMI1  
Affinity Capture-MS Homo sapiens
35 TEAD1  
Proximity Label-MS Homo sapiens
36 CRCP  
Affinity Capture-MS Homo sapiens
37 BRD4 23476
Affinity Capture-MS Homo sapiens
38 KLF4  
Proximity Label-MS Homo sapiens
39 LHX4  
Proximity Label-MS Homo sapiens
40 MYCN  
Affinity Capture-MS Homo sapiens
41 TEX13B  
Affinity Capture-MS Homo sapiens
42 SMARCB1 6598
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 SMARCA2 6595
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 MTA2 9219
Co-fractionation Homo sapiens
45 NFIB  
Proximity Label-MS Homo sapiens
46 SAMHD1 25939
Affinity Capture-MS Homo sapiens
47 PHF10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 FOXC1  
Affinity Capture-MS Homo sapiens
49 SOX17  
Proximity Label-MS Homo sapiens
50 QPRT 23475
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 NFATC2  
Affinity Capture-MS Homo sapiens
52 TBR1  
Proximity Label-MS Homo sapiens
53 XRN1 54464
Two-hybrid Homo sapiens
54 NFIX 4784
Proximity Label-MS Homo sapiens
55 GLTSCR1 29998
Affinity Capture-MS Homo sapiens
56 Smarcc1  
Affinity Capture-MS Mus musculus
57 SMARCA4 6597
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
58 LHX1  
Proximity Label-MS Homo sapiens
59 NFIA 4774
Proximity Label-MS Homo sapiens
60 RPA2 6118
Proximity Label-MS Homo sapiens
61 GATA3  
Proximity Label-MS Homo sapiens
62 NTRK1 4914
Affinity Capture-MS Homo sapiens
63 ACTL6A 86
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 LHX3  
Proximity Label-MS Homo sapiens
65 LHX8  
Proximity Label-MS Homo sapiens
66 PAX8  
Proximity Label-MS Homo sapiens
67 ACTB 60
Affinity Capture-MS Homo sapiens
68 T  
Proximity Label-MS Homo sapiens
69 MBD3 53615
Co-fractionation Homo sapiens
70 SS18L1  
Affinity Capture-MS Homo sapiens
71 ACTG1 71
Affinity Capture-MS Homo sapiens
72 OGT 8473
Reconstituted Complex Homo sapiens
73 BCL7C  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 SOX7  
Proximity Label-MS Homo sapiens
75 NOTCH2NL 388677
Two-hybrid Homo sapiens
76 BRD7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 HNRNPD 3184
Affinity Capture-MS Homo sapiens
78 DPF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 NR4A1  
Affinity Capture-MS Homo sapiens
80 SMARCAD1  
Affinity Capture-MS Homo sapiens
81 BAZ1B 9031
Co-fractionation Homo sapiens
82 SMARCD1 6602
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 IKZF3  
Affinity Capture-MS Homo sapiens
84 RELB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 FOXI1  
Proximity Label-MS Homo sapiens
86 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 BPTF 2186
Co-fractionation Homo sapiens
88 ARF6 382
Affinity Capture-MS Homo sapiens
89 IKZF1  
Affinity Capture-MS Homo sapiens
90 TP73  
Affinity Capture-Western Homo sapiens
91 SS18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 ARID1B 57492
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 HNF4A  
Proximity Label-MS Homo sapiens
94 PRMT5 10419
Co-fractionation Homo sapiens
95 FANCA  
Affinity Capture-Luminescence Homo sapiens
96 FOS 2353
Proximity Label-MS Homo sapiens
97 SS18L2  
Affinity Capture-MS Homo sapiens
98 RPA3 6119
Proximity Label-MS Homo sapiens
99 TP63  
Affinity Capture-Western Homo sapiens
100 ETS1  
Proximity Label-MS Homo sapiens
101 TBL1X 6907
Co-fractionation Homo sapiens
102 RNF2  
Affinity Capture-MS Homo sapiens
103 ARID1A 8289
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 CEBPA  
Proximity Label-MS Homo sapiens
Protein-peptide Homo sapiens
105 RBBP5 5929
Co-fractionation Homo sapiens
106 IRF1  
Proximity Label-MS Homo sapiens
107 BRD3 8019
Affinity Capture-MS Homo sapiens
108 SOX2  
Proximity Label-MS Homo sapiens
109 TLX1  
Proximity Label-MS Homo sapiens
110 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
111 SMARCD3  
Affinity Capture-MS Homo sapiens
112 SIRT6  
Affinity Capture-MS Homo sapiens
113 ARID2  
Affinity Capture-MS Homo sapiens
114 ELF5  
Proximity Label-MS Homo sapiens
115 STK11IP 114790
Affinity Capture-MS Homo sapiens
116 TP53 7157
Affinity Capture-Western Homo sapiens
117 SMARCC1 6599
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 UPF2 26019
Co-fractionation Homo sapiens
119 PBRM1 55193
Affinity Capture-MS Homo sapiens
120 SP7  
Proximity Label-MS Homo sapiens
121 PAX9  
Proximity Label-MS Homo sapiens
122 SIRT1  
Co-fractionation Homo sapiens
123 MKI67  
Affinity Capture-MS Homo sapiens
124 ESR1  
Affinity Capture-MS Homo sapiens
125 KLF5  
Proximity Label-MS Homo sapiens
126 WWP2 11060
Affinity Capture-MS Homo sapiens
127 NUP50 10762
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 PAX7  
Proximity Label-MS Homo sapiens
129 HDGFRP2 84717
Affinity Capture-MS Homo sapiens
130 DPF3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 CIT 11113
Affinity Capture-MS Homo sapiens
132 KYNU  
Co-fractionation Homo sapiens
133 ERG  
Proximity Label-MS Homo sapiens
134 NFIC 4782
Proximity Label-MS Homo sapiens
135 AR 367
Proximity Label-MS Homo sapiens
136 MYC  
Affinity Capture-MS Homo sapiens
137 Bcl7c  
Affinity Capture-MS Mus musculus
138 BCL7A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 SMARCC2 6601
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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