Gene description for ARID1B
Gene name AT rich interactive domain 1B (SWI1-like)
Gene symbol ARID1B
Other names/aliases 6A3-5
BAF250B
BRIGHT
DAN15
ELD/OSA1
MRD12
OSA2
P250R
Species Homo sapiens
 Database cross references - ARID1B
ExoCarta ExoCarta_57492
Entrez Gene 57492
HGNC 18040
MIM 614556
UniProt Q8NFD5  
 ARID1B identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ARID1B
Molecular Function
    DNA binding GO:0003677 IEA
    protein binding GO:0005515 IPI
    transcription coactivator activity GO:0003713 NAS
Biological Process
    chromatin-mediated maintenance of transcription GO:0048096 NAS
    transcription, DNA-templated GO:0006351 IEA
    nervous system development GO:0007399 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    SWI/SNF complex GO:0016514 IDA
    nBAF complex GO:0071565 IEA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified ARID1B in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ARID1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SMARCB1 6598
Affinity Capture-MS Homo sapiens
2 SMARCA2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
3 SMARCA4 6597
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which ARID1B is involved
PathwayEvidenceSource
RMTs methylate histone arginines TAS Reactome





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