Gene description for SMARCA1
Gene name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Gene symbol SMARCA1
Other names/aliases ISWI
NURF140
SNF2L
SNF2L1
SNF2LB
SNF2LT
SWI
SWI2
Species Homo sapiens
 Database cross references - SMARCA1
ExoCarta ExoCarta_6594
Vesiclepedia VP_6594
Entrez Gene 6594
HGNC 11097
MIM 300012
UniProt P28370  
 SMARCA1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SMARCA1
Molecular Function
    nucleosome-dependent ATPase activity GO:0070615 IDA
    DNA-dependent ATPase activity GO:0008094 IDA
    DNA binding GO:0003677 IEA
    nucleosome binding GO:0031491 IEA
    protein binding GO:0005515 IPI
    helicase activity GO:0004386 IEA
    ATP binding GO:0005524 IEA
    annealing helicase activity GO:0036310 IDA
Biological Process
    brain development GO:0007420 IMP
    ATP-dependent chromatin remodeling GO:0043044 IDA
    positive regulation of transcription, DNA-templated GO:0045893 IMP
    DNA strand renaturation GO:0000733 IDA
    chromatin remodeling GO:0006338 IDA
    neuron differentiation GO:0030182 ISS
    transcription, DNA-templated GO:0006351 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    NURF complex GO:0016589 IDA
    CERF complex GO:0090537 IDA
 Experiment description of studies that identified SMARCA1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SMARCA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SMARCA1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here