Gene description for BPTF
Gene name bromodomain PHD finger transcription factor
Gene symbol BPTF
Other names/aliases FAC1
FALZ
NURF301
Species Homo sapiens
 Database cross references - BPTF
ExoCarta ExoCarta_2186
Entrez Gene 2186
HGNC 3581
MIM 601819
UniProt Q12830  
 BPTF identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for BPTF
Molecular Function
    DNA-dependent ATPase activity GO:0008094 IDA
    sequence-specific DNA binding GO:0043565 IMP
    protein binding GO:0005515 IPI
    transcription factor binding GO:0008134 IDA
    zinc ion binding GO:0008270 IEA
Biological Process
    regulation of transcription, DNA-templated GO:0006355 IMP
    chromatin remodeling GO:0006338 IDA
    embryonic placenta development GO:0001892 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IMP
    endoderm development GO:0007492 IEA
    anterior/posterior pattern specification GO:0009952 IEA
    brain development GO:0007420 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    transcription, DNA-templated GO:0006351 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    extracellular exosome GO:0070062 IDA
    NURF complex GO:0016589 IDA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified BPTF in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for BPTF
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAZ 4150
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which BPTF is involved
No pathways found





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