Gene description for MAZ
Gene name MYC-associated zinc finger protein (purine-binding transcription factor)
Gene symbol MAZ
Other names/aliases PUR1
Pur-1
SAF-1
SAF-2
SAF-3
ZF87
ZNF801
Zif87
Species Homo sapiens
 Database cross references - MAZ
ExoCarta ExoCarta_4150
Vesiclepedia VP_4150
Entrez Gene 4150
HGNC 6914
MIM 600999
UniProt P56270  
 MAZ identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for MAZ
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    transcription initiation at RNA polymerase II promoter GO:0006367 IDA
    termination of RNA polymerase II transcription GO:0006369 IDA
    positive regulation of cell population proliferation GO:0008284 IDA
    positive regulation of gene expression GO:0010628 IDA
    positive regulation of cell migration GO:0030335 IDA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IDA
    negative regulation of apoptotic signaling pathway GO:2001234 IDA
Subcellular Localization
    nucleus GO:0005634 ISS
 Experiment description of studies that identified MAZ in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for MAZ
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RBPMS 11030
Two-hybrid Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 CDC14B 8555
Proximity Label-MS Homo sapiens
4 MECP2 4204
Affinity Capture-MS Homo sapiens
5 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
6 MYCN  
Affinity Capture-MS Homo sapiens
7 KLF15  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
8 ARHGEF19  
Affinity Capture-MS Homo sapiens
9 UBE2O 63893
Affinity Capture-MS Homo sapiens
10 CENPA  
Proximity Label-MS Homo sapiens
11 FBXL6  
Affinity Capture-MS Homo sapiens
12 NOTCH2 4853
Affinity Capture-MS Homo sapiens
13 Arhgap1 228359
Affinity Capture-MS Mus musculus
14 RC3H2  
Affinity Capture-MS Homo sapiens
15 KDM4D  
Affinity Capture-MS Homo sapiens
16 APEX1 328
Proximity Label-MS Homo sapiens
17 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
18 KEAP1 9817
Affinity Capture-MS Homo sapiens
19 DMRTB1  
Two-hybrid Homo sapiens
20 KLF8  
Affinity Capture-MS Homo sapiens
21 CUL3 8452
Affinity Capture-MS Homo sapiens
22 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
23 FOS 2353
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 Sf3a3 75062
Two-hybrid Mus musculus
25 CSNK2A1 1457
Biochemical Activity Homo sapiens
26 PARK2  
Affinity Capture-MS Homo sapiens
27 OTUB1 55611
Affinity Capture-MS Homo sapiens
28 Nudt21 68219
Two-hybrid Mus musculus
29 APOD 347
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 NXF1 10482
Affinity Capture-RNA Homo sapiens
31 UFL1 23376
Affinity Capture-MS Homo sapiens
32 JUN 3725
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
33 MOV10 4343
Affinity Capture-RNA Homo sapiens
34 MYC  
Affinity Capture-MS Homo sapiens
35 HECW2  
Affinity Capture-MS Homo sapiens
36 OGT 8473
Reconstituted Complex Homo sapiens
37 AIM2  
Affinity Capture-MS Homo sapiens
38 TRIM31  
Affinity Capture-MS Homo sapiens
39 BPTF 2186
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
40 EHMT2 10919
Two-hybrid Homo sapiens
41 TOLLIP 54472
Proximity Label-MS Homo sapiens
42 DCC  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
43 BRD1 23774
Affinity Capture-MS Homo sapiens
44 SERBP1 26135
Affinity Capture-MS Homo sapiens
45 DDRGK1 65992
Affinity Capture-MS Homo sapiens
46 MAPK14 1432
Affinity Capture-MS Homo sapiens
47 RC3H1 149041
Affinity Capture-MS Homo sapiens
48 TIAM1  
Affinity Capture-MS Homo sapiens
49 RPA3 6119
Proximity Label-MS Homo sapiens
50 KRT31 3881
Two-hybrid Homo sapiens
51 TEAD1  
Proximity Label-MS Homo sapiens
52 Cpsf6  
Two-hybrid Mus musculus
53 KLF5  
Affinity Capture-MS Homo sapiens
54 EP300 2033
Affinity Capture-MS Homo sapiens
55 KRTAP10-9  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which MAZ is involved
No pathways found





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