Gene description for CDC14B
Gene name cell division cycle 14B
Gene symbol CDC14B
Other names/aliases CDC14B3
Cdc14B1
Cdc14B2
hCDC14B
Species Homo sapiens
 Database cross references - CDC14B
ExoCarta ExoCarta_8555
Vesiclepedia VP_8555
Entrez Gene 8555
HGNC 1719
MIM 603505
UniProt O60729  
 CDC14B identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CDC14B
Molecular Function
    protein serine/threonine phosphatase activity GO:0004722 IBA
    protein serine/threonine phosphatase activity GO:0004722 IDA
    protein serine/threonine phosphatase activity GO:0004722 TAS
    protein tyrosine phosphatase activity GO:0004725 IBA
    protein tyrosine phosphatase activity GO:0004725 IDA
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    protein binding GO:0005515 IPI
    myosin phosphatase activity GO:0017018 IEA
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    calmodulin-dependent protein phosphatase activity GO:0033192 IEA
    histone H2AXS140 phosphatase activity GO:0140791 IEA
    histone H2AXY142 phosphatase activity GO:0140793 IEA
    RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA
    RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA
    RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA
    RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA
    RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA
    MAP kinase serine/threonine phosphatase activity GO:1990439 IEA
Biological Process
    microtubule cytoskeleton organization GO:0000226 IBA
    DNA repair GO:0006281 IEA
    chromatin remodeling GO:0006338 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    protein dephosphorylation GO:0006470 IMP
    protein dephosphorylation GO:0006470 NAS
    mitotic G2 DNA damage checkpoint signaling GO:0007095 IDA
    regulation of exit from mitosis GO:0007096 IBA
    positive regulation of cytokinesis GO:0032467 IBA
    cilium assembly GO:0060271 IBA
    positive regulation of ubiquitin protein ligase activity GO:1904668 IMP
Subcellular Localization
    spindle pole GO:0000922 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IBA
    mitotic spindle GO:0072686 IBA
 Experiment description of studies that identified CDC14B in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CDC14B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNL2 29889
Proximity Label-MS Homo sapiens
2 CDC14B 8555
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 NOP14 8602
Proximity Label-MS Homo sapiens
4 CDCA2 157313
Proximity Label-MS Homo sapiens
5 GTF2F1 2962
Proximity Label-MS Homo sapiens
6 ZNF174  
Proximity Label-MS Homo sapiens
7 MRPL48  
Affinity Capture-MS Homo sapiens
8 AATF  
Proximity Label-MS Homo sapiens
9 MSH6 2956
Proximity Label-MS Homo sapiens
10 RPS19BP1  
Affinity Capture-MS Homo sapiens
11 PRPF38A 84950
Proximity Label-MS Homo sapiens
12 CENPC  
Proximity Label-MS Homo sapiens
13 SUB1 10923
Proximity Label-MS Homo sapiens
14 NMNAT1  
Affinity Capture-MS Homo sapiens
15 ESF1 51575
Proximity Label-MS Homo sapiens
16 BRD2  
Proximity Label-MS Homo sapiens
17 CSNK2A1 1457
Proximity Label-MS Homo sapiens
18 SRFBP1  
Proximity Label-MS Homo sapiens
19 UTP3 57050
Proximity Label-MS Homo sapiens
20 HMGCS1 3157
Affinity Capture-MS Homo sapiens
21 ANKRD50 57182
Affinity Capture-MS Homo sapiens
22 USP36  
Proximity Label-MS Homo sapiens
23 TCEB3 6924
Proximity Label-MS Homo sapiens
24 XRCC1 7515
Proximity Label-MS Homo sapiens
25 PPP1R12A 4659
Affinity Capture-MS Homo sapiens
26 SNRNP70 6625
Affinity Capture-MS Homo sapiens
27 MRPS34 65993
Affinity Capture-MS Homo sapiens
28 TFAM 7019
Affinity Capture-MS Homo sapiens
29 KIF22  
Proximity Label-MS Homo sapiens
30 RRP12 23223
Proximity Label-MS Homo sapiens
31 FZR1  
Affinity Capture-Western Homo sapiens
32 PRC1 9055
Affinity Capture-MS Homo sapiens
33 MRPS23 51649
Affinity Capture-MS Homo sapiens
34 MRPS24 64951
Affinity Capture-MS Homo sapiens
35 ZNF512B  
Proximity Label-MS Homo sapiens
36 ATAD5  
Proximity Label-MS Homo sapiens
37 KRI1  
Proximity Label-MS Homo sapiens
38 HMGA1 3159
Proximity Label-MS Homo sapiens
39 MRPS26 64949
Affinity Capture-MS Homo sapiens
40 HELLS 3070
Proximity Label-MS Homo sapiens
41 GINS4  
Affinity Capture-MS Homo sapiens
42 NUSAP1 51203
Proximity Label-MS Homo sapiens
43 CDCA8 55143
Proximity Label-MS Homo sapiens
44 MRPS7 51081
Affinity Capture-MS Homo sapiens
45 WIZ 58525
Proximity Label-MS Homo sapiens
46 MRPL47 57129
Affinity Capture-MS Homo sapiens
47 CCDC86  
Proximity Label-MS Homo sapiens
48 PES1 23481
Proximity Label-MS Homo sapiens
49 C1QBP 708
Proximity Label-MS Homo sapiens
50 MRPL13  
Affinity Capture-MS Homo sapiens
51 DDX31  
Proximity Label-MS Homo sapiens
52 SRP14 6727
Affinity Capture-MS Homo sapiens
53 PINX1  
Proximity Label-MS Homo sapiens
54 WHSC1 7468
Proximity Label-MS Homo sapiens
55 PPP6R2 9701
Affinity Capture-MS Homo sapiens
56 DEK 7913
Proximity Label-MS Homo sapiens
57 MRPS2 51116
Affinity Capture-MS Homo sapiens
58 ZKSCAN4  
Proximity Label-MS Homo sapiens
59 MRPS6  
Affinity Capture-MS Homo sapiens
60 NOC4L 79050
Proximity Label-MS Homo sapiens
61 NUDT16 131870
Affinity Capture-MS Homo sapiens
62 XPOT 11260
Proximity Label-MS Homo sapiens
63 ZC3HAV1L 92092
Affinity Capture-MS Homo sapiens
64 UBTF 7343
Proximity Label-MS Homo sapiens
65 RPL36 25873
Affinity Capture-MS Homo sapiens
66 WHSC1L1  
Proximity Label-MS Homo sapiens
67 SDAD1  
Proximity Label-MS Homo sapiens
68 RRP1B 23076
Proximity Label-MS Homo sapiens
69 SKP2  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
70 MYBBP1A 10514
Proximity Label-MS Homo sapiens
71 DDX27 55661
Proximity Label-MS Homo sapiens
72 MRPS33  
Affinity Capture-MS Homo sapiens
73 GLTSCR2  
Proximity Label-MS Homo sapiens
74 ANKRD28 23243
Affinity Capture-MS Homo sapiens
75 GINS2  
Affinity Capture-MS Homo sapiens
76 CIRBP 1153
Affinity Capture-MS Homo sapiens
77 BMS1  
Proximity Label-MS Homo sapiens
78 MAZ 4150
Proximity Label-MS Homo sapiens
79 NOC3L 64318
Proximity Label-MS Homo sapiens
80 MSH2 4436
Proximity Label-MS Homo sapiens
81 LY6G5B  
Affinity Capture-MS Homo sapiens
82 MRPS11  
Affinity Capture-MS Homo sapiens
83 RNF169  
Proximity Label-MS Homo sapiens
84 ANKRD44 91526
Affinity Capture-MS Homo sapiens
85 NAT10 55226
Proximity Label-MS Homo sapiens
86 MRPS14  
Affinity Capture-MS Homo sapiens
87 MRPL16  
Affinity Capture-MS Homo sapiens
88 PHF2  
Proximity Label-MS Homo sapiens
89 GADD45GIP1  
Affinity Capture-MS Homo sapiens
90 DCAF16 54876
Affinity Capture-MS Homo sapiens
91 CBX2  
Proximity Label-MS Homo sapiens
92 MRPS16  
Affinity Capture-MS Homo sapiens
93 MRPS28  
Affinity Capture-MS Homo sapiens
94 AURKB 9212
Proximity Label-MS Homo sapiens
95 ZNF512  
Proximity Label-MS Homo sapiens
96 ANKRD52 283373
Affinity Capture-MS Homo sapiens
97 L3MBTL3  
Proximity Label-MS Homo sapiens
98 MRPL19 9801
Affinity Capture-MS Homo sapiens
99 USP47 55031
Affinity Capture-MS Homo sapiens
100 CEBPZ  
Proximity Label-MS Homo sapiens
101 GINS1  
Affinity Capture-MS Homo sapiens
102 CACTIN  
Proximity Label-MS Homo sapiens
103 NOP16 51491
Affinity Capture-MS Homo sapiens
104 TSR1 55720
Proximity Label-MS Homo sapiens
105 RPL26 6154
Affinity Capture-MS Homo sapiens
106 BRD3 8019
Proximity Label-MS Homo sapiens
107 FTSJ3 117246
Proximity Label-MS Homo sapiens
108 DDX50 79009
Proximity Label-MS Homo sapiens
109 TP53 7157
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
110 HMGB1 3146
Proximity Label-MS Homo sapiens
111 NOL10  
Proximity Label-MS Homo sapiens
112 SRSF9 8683
Affinity Capture-MS Homo sapiens
113 GRHPR 9380
Affinity Capture-MS Homo sapiens
114 ZNF362  
Proximity Label-MS Homo sapiens
115 RPS12 6206
Affinity Capture-MS Homo sapiens
116 PHF8  
Proximity Label-MS Homo sapiens
117 MRPS15  
Affinity Capture-MS Homo sapiens
118 RPS10P5 93144
Affinity Capture-MS Homo sapiens
119 MRPS10 55173
Affinity Capture-MS Homo sapiens
120 NIFK 84365
Proximity Label-MS Homo sapiens
121 MRPS21  
Affinity Capture-MS Homo sapiens
122 ZNF280C  
Proximity Label-MS Homo sapiens
123 PHKA2 5256
Affinity Capture-MS Homo sapiens
124 AHCYL2 23382
Affinity Capture-MS Homo sapiens
125 TRIM36  
Affinity Capture-MS Homo sapiens
126 MRPL46  
Affinity Capture-MS Homo sapiens
127 CBX8 57332
Proximity Label-MS Homo sapiens
128 THNSL1 79896
Affinity Capture-MS Homo sapiens
129 GTF2E1 2960
Proximity Label-MS Homo sapiens
130 GLYR1 84656
Proximity Label-MS Homo sapiens
131 MRPS25 64432
Affinity Capture-MS Homo sapiens
132 RPL36AL 6166
Affinity Capture-MS Homo sapiens
133 NUCKS1 64710
Proximity Label-MS Homo sapiens
134 DNMT1 1786
Proximity Label-MS Homo sapiens
135 TEX10 54881
Proximity Label-MS Homo sapiens
136 GINS3  
Affinity Capture-MS Homo sapiens
137 C5orf22  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CDC14B is involved
PathwayEvidenceSource
MAPK family signaling cascades TAS Reactome
MAPK6/MAPK4 signaling TAS Reactome
Signal Transduction TAS Reactome





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