Gene description for CDC14B
Gene name cell division cycle 14B
Gene symbol CDC14B
Other names/aliases CDC14B3
Cdc14B1
Cdc14B2
hCDC14B
Species Homo sapiens
 Database cross references - CDC14B
ExoCarta ExoCarta_8555
Entrez Gene 8555
HGNC 1719
MIM 603505
UniProt O60729  
 CDC14B identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CDC14B
Molecular Function
    protein tyrosine/serine/threonine phosphatase activity GO:0008138 IEA
    protein serine/threonine phosphatase activity GO:0004722 IDA
    protein binding GO:0005515 IPI
    protein tyrosine phosphatase activity GO:0004725 IDA
Biological Process
    activation of anaphase-promoting complex activity GO:0051488 IMP
    peptidyl-tyrosine dephosphorylation GO:0035335 IEA
    G2 DNA damage checkpoint GO:0031572 IDA
    DNA repair GO:0006281 IEA
    protein dephosphorylation GO:0006470 NAS
Subcellular Localization
    nuclear membrane GO:0031965 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
 Experiment description of studies that identified CDC14B in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CDC14B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TP53  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which CDC14B is involved
No pathways found





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