Gene description for CDCA2
Gene name cell division cycle associated 2
Gene symbol CDCA2
Other names/aliases PPP1R81
Repo-Man
Species Homo sapiens
 Database cross references - CDCA2
ExoCarta ExoCarta_157313
Vesiclepedia VP_157313
Entrez Gene 157313
HGNC 14623
UniProt Q69YH5  
 CDCA2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CDCA2
Molecular Function
    protein phosphatase regulator activity GO:0019888 IMP
Biological Process
    chromosome segregation GO:0007059 IEA
    regulation of mitotic nuclear division GO:0007088 IBA
    cell division GO:0051301 IEA
    regulation of chromosome segregation GO:0051983 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    chromosome GO:0005694 IBA
    chromosome GO:0005694 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified CDCA2 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CDCA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3EAP  
Proximity Label-MS Homo sapiens
2 CDC14B 8555
Proximity Label-MS Homo sapiens
3 PHLPP1  
Proximity Label-MS Homo sapiens
4 SLX4  
Affinity Capture-MS Homo sapiens
5 PPP1CB 5500
Affinity Capture-MS Homo sapiens
6 PPP1R3A  
Affinity Capture-MS Homo sapiens
7 SIRT6  
Affinity Capture-MS Homo sapiens
8 PARP1 142
Proximity Label-MS Homo sapiens
9 HIST1H3A 8350
Proximity Label-MS Homo sapiens
10 Nup98  
Affinity Capture-MS Mus musculus
11 KPNA1 3836
Affinity Capture-MS Homo sapiens
12 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
13 ASF1A 25842
Proximity Label-MS Homo sapiens
14 KLF9 687
Proximity Label-MS Homo sapiens
15 KLF16  
Proximity Label-MS Homo sapiens
16 APEX1 328
Proximity Label-MS Homo sapiens
17 MBD4  
Two-hybrid Homo sapiens
18 JMJD6 23210
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 BRCA1 672
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
20 IER2 9592
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CUL3 8452
Affinity Capture-MS Homo sapiens
22 PPP1CA 5499
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
23 KPNA2 3838
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 YY1 7528
Proximity Label-MS Homo sapiens
25 TCEAL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 Rcc1  
Affinity Capture-MS Mus musculus
27 RGPD1  
Affinity Capture-MS Homo sapiens
28 CDK1 983
Biochemical Activity Homo sapiens
29 CENPA  
Proximity Label-MS Homo sapiens
30 PPP1CC 5501
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 CBX3 11335
Proximity Label-MS Homo sapiens
32 NUP50 10762
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
34 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
35 TFAM 7019
Cross-Linking-MS (XL-MS) Homo sapiens
36 RAN 5901
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 LMNB1 4001
Proximity Label-MS Homo sapiens
38 KLF8  
Proximity Label-MS Homo sapiens
39 B2M 567
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 NUP153 9972
Affinity Capture-MS Homo sapiens
41 NPIPB6  
Affinity Capture-MS Homo sapiens
42 Ranbp2  
Affinity Capture-MS Mus musculus
43 XRCC6 2547
Proximity Label-MS Homo sapiens
44 KPNB1 3837
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 SPDYE4  
Proximity Label-MS Homo sapiens
46 AR 367
Proximity Label-MS Homo sapiens
47 HECTD1 25831
Affinity Capture-MS Homo sapiens
48 LMNA 4000
Proximity Label-MS Homo sapiens
49 S100A2 6273
Affinity Capture-MS Homo sapiens
50 PPP2R5B 5526
Affinity Capture-MS Homo sapiens
51 NHLH1  
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CDCA2 is involved
No pathways found





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