Gene description for GNL2
Gene name guanine nucleotide binding protein-like 2 (nucleolar)
Gene symbol GNL2
Other names/aliases HUMAUANTIG
NGP1
Ngp-1
Nog2
Nug2
Species Homo sapiens
 Database cross references - GNL2
ExoCarta ExoCarta_29889
Vesiclepedia VP_29889
Entrez Gene 29889
HGNC 29925
MIM 609365
UniProt Q13823  
 GNL2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for GNL2
Molecular Function
    RNA binding GO:0003723 HDA
    GTPase activity GO:0003924 NAS
    GTP binding GO:0005525 NAS
Biological Process
    ribosome biogenesis GO:0042254 IEA
Subcellular Localization
    nucleus GO:0005634 TAS
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 IDA
    membrane GO:0016020 HDA
 Experiment description of studies that identified GNL2 in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for GNL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IWS1  
Affinity Capture-MS Homo sapiens
2 RPL11 6135
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CDC14B 8555
Proximity Label-MS Homo sapiens
4 SRP19 6728
Affinity Capture-MS Homo sapiens
5 MLLT4 4301
Affinity Capture-MS Homo sapiens
6 ZNF668  
Affinity Capture-MS Homo sapiens
7 RPSAP58 388524
Affinity Capture-MS Homo sapiens
8 UBE2H 7328
Affinity Capture-MS Homo sapiens
9 RPL26L1 51121
Affinity Capture-MS Homo sapiens
10 RSL1D1 26156
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 DNAJC9 23234
Proximity Label-MS Homo sapiens
12 SET 6418
Affinity Capture-MS Homo sapiens
13 DNAJC8 22826
Proximity Label-MS Homo sapiens
14 RPS3A 6189
Affinity Capture-MS Homo sapiens
15 SPATS2  
Affinity Capture-MS Homo sapiens
16 TCEB3 6924
Affinity Capture-MS Homo sapiens
17 RPL30 6156
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 SRPK2 6733
Affinity Capture-MS Homo sapiens
19 MRPS27 23107
Affinity Capture-MS Homo sapiens
20 HIST1H1D 3007
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 LHX2  
Proximity Label-MS Homo sapiens
22 RPL13A 23521
Affinity Capture-MS Homo sapiens
23 RPL37A 6168
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 THAP3  
Affinity Capture-MS Homo sapiens
25 NOP56 10528
Proximity Label-MS Homo sapiens
26 RBMXL1  
Affinity Capture-MS Homo sapiens
27 RPS19 6223
Affinity Capture-MS Homo sapiens
28 RPL10 6134
Affinity Capture-MS Homo sapiens
29 CHCHD1  
Proximity Label-MS Homo sapiens
30 ADD3 120
Affinity Capture-MS Homo sapiens
31 RPL14 9045
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 PNMAL1  
Affinity Capture-MS Homo sapiens
33 CAND1 55832
Affinity Capture-MS Homo sapiens
34 FGF3  
Affinity Capture-MS Homo sapiens
35 RBM15B  
Affinity Capture-MS Homo sapiens
36 SRP72 6731
Affinity Capture-MS Homo sapiens
37 SNIP1  
Affinity Capture-MS Homo sapiens
38 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
39 CENPA  
Proximity Label-MS Homo sapiens
40 DNAJB6 10049
Proximity Label-MS Homo sapiens
41 USP36  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 KIF20B  
Affinity Capture-MS Homo sapiens
43 CUL7 9820
Affinity Capture-MS Homo sapiens
44 DDX23 9416
Proximity Label-MS Homo sapiens
45 GPATCH4 54865
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 ETV3  
Proximity Label-MS Homo sapiens
47 ADARB1 104
Affinity Capture-MS Homo sapiens
48 PRR11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 RBM28 55131
Affinity Capture-MS Homo sapiens
50 RPL7A 6130
Affinity Capture-MS Homo sapiens
51 TFAM 7019
Affinity Capture-MS Homo sapiens
52 GTF2F2 2963
Affinity Capture-MS Homo sapiens
53 GTF2F1 2962
Affinity Capture-MS Homo sapiens
54 CDK11B 984
Affinity Capture-MS Homo sapiens
55 PRPF38B 55119
Affinity Capture-MS Homo sapiens
56 WDR74 54663
Co-fractionation Homo sapiens
57 RRP12 23223
Affinity Capture-MS Homo sapiens
58 MRPS5 64969
Affinity Capture-MS Homo sapiens
59 METAP2 10988
Affinity Capture-MS Homo sapiens
60 PRC1 9055
Affinity Capture-MS Homo sapiens
61 MRPS23 51649
Affinity Capture-MS Homo sapiens
62 MRPS24 64951
Affinity Capture-MS Homo sapiens
63 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 ANOS1 3730
Affinity Capture-MS Homo sapiens
65 ZGPAT  
Affinity Capture-MS Homo sapiens
66 RPS8 6202
Affinity Capture-MS Homo sapiens
67 BRPF3  
Affinity Capture-MS Homo sapiens
68 POLR1E  
Proximity Label-MS Homo sapiens
69 ZNF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 RPS9 6203
Affinity Capture-MS Homo sapiens
71 SRP14 6727
Affinity Capture-MS Homo sapiens
72 SRSF3 6428
Affinity Capture-MS Homo sapiens
73 NFATC2IP  
Affinity Capture-MS Homo sapiens
74 PRKRA 8575
Affinity Capture-MS Homo sapiens
75 SRP68 6730
Affinity Capture-MS Homo sapiens
76 LEO1 123169
Affinity Capture-MS Homo sapiens
77 DDX18 8886
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 RRP8  
Affinity Capture-MS Homo sapiens
79 FBL 2091
Proximity Label-MS Homo sapiens
80 MTDH 92140
Affinity Capture-MS Homo sapiens
81 ZNF346  
Affinity Capture-MS Homo sapiens
82 MRPS7 51081
Affinity Capture-MS Homo sapiens
83 MECP2 4204
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 Eif3a 13669
Affinity Capture-MS Mus musculus
85 MYCN  
Affinity Capture-MS Homo sapiens
86 RBM42  
Affinity Capture-MS Homo sapiens
87 OASL 8638
Affinity Capture-MS Homo sapiens
88 C12orf43  
Affinity Capture-MS Homo sapiens
89 C11orf57  
Affinity Capture-MS Homo sapiens
90 OBSL1 23363
Affinity Capture-MS Homo sapiens
91 RBM8A 9939
Affinity Capture-MS Homo sapiens
92 KIF14 9928
Affinity Capture-MS Homo sapiens
93 LIN28A  
Affinity Capture-MS Homo sapiens
94 STRBP 55342
Affinity Capture-MS Homo sapiens
95 KLF16  
Proximity Label-MS Homo sapiens
96 MRPS35 60488
Affinity Capture-MS Homo sapiens
97 KIFC1 3833
Affinity Capture-MS Homo sapiens
98 MRPS25 64432
Affinity Capture-MS Homo sapiens
99 ING4  
Affinity Capture-MS Homo sapiens
100 DDX21 9188
Affinity Capture-MS Homo sapiens
101 LIN28B  
Affinity Capture-MS Homo sapiens
102 MRPS26 64949
Affinity Capture-MS Homo sapiens
103 PINX1  
Affinity Capture-MS Homo sapiens
104 RPL4 6124
Affinity Capture-MS Homo sapiens
105 MRPS34 65993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 RBM19 9904
Affinity Capture-MS Homo sapiens
107 ZBTB47  
Affinity Capture-MS Homo sapiens
108 RBM4B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 YBX2 51087
Affinity Capture-MS Homo sapiens
110 BLM 641
Affinity Capture-MS Homo sapiens
111 MCM10 55388
Affinity Capture-MS Homo sapiens
112 SRSF6 6431
Affinity Capture-MS Homo sapiens
113 PURG  
Affinity Capture-MS Homo sapiens
114 ZBTB48  
Affinity Capture-MS Homo sapiens
115 RPL5 6125
Affinity Capture-MS Homo sapiens
116 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
117 RPL18A 6142
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 ZCCHC17  
Affinity Capture-MS Homo sapiens
119 ADD2 119
Affinity Capture-MS Homo sapiens
120 Srp72  
Affinity Capture-MS Mus musculus
121 NUMB 8650
Affinity Capture-MS Homo sapiens
122 RPS10 6204
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 NTRK1 4914
Affinity Capture-MS Homo sapiens
124 RPL31 6160
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 IFI16 3428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 REXO4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 TJP2 9414
Affinity Capture-MS Homo sapiens
129 DICER1  
Affinity Capture-MS Homo sapiens
130 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
131 NOB1  
Co-fractionation Homo sapiens
132 REPS2  
Co-fractionation Homo sapiens
133 UTP11L  
Affinity Capture-MS Homo sapiens
134 SNRNP27  
Affinity Capture-MS Homo sapiens
135 HECTD1 25831
Affinity Capture-MS Homo sapiens
136 RPLP0 6175
Affinity Capture-MS Homo sapiens
137 SRPK3  
Affinity Capture-MS Homo sapiens
138 MAGEB2 4113
Affinity Capture-MS Homo sapiens
139 RANBP6 26953
Affinity Capture-MS Homo sapiens
140 CDX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 MYBBP1A 10514
Affinity Capture-MS Homo sapiens
142 GTPBP4 23560
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
143 GLTSCR2  
Affinity Capture-MS Homo sapiens
144 H1FNT  
Affinity Capture-MS Homo sapiens
145 CD3EAP  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 WDR46  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
147 CNBP 7555
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 FGFBP1 9982
Affinity Capture-MS Homo sapiens
149 HABP4  
Affinity Capture-MS Homo sapiens
150 ZBTB2 57621
Affinity Capture-MS Homo sapiens
151 ESF1 51575
Affinity Capture-MS Homo sapiens
152 ZAK 51776
Affinity Capture-MS Homo sapiens
153 IPO5 3843
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
154 SPATS2L 26010
Affinity Capture-MS Homo sapiens
155 ABT1 29777
Affinity Capture-MS Homo sapiens
156 SRSF7 6432
Affinity Capture-MS Homo sapiens
157 MRTO4 51154
Co-fractionation Homo sapiens
158 RPS2 6187
Affinity Capture-MS Homo sapiens
159 RPL15 6138
Affinity Capture-MS Homo sapiens
160 EIF6 3692
Proximity Label-MS Homo sapiens
161 RC3H2  
Affinity Capture-MS Homo sapiens
162 SIRT7  
Affinity Capture-MS Homo sapiens
163 SRSF4 6429
Affinity Capture-MS Homo sapiens
164 SRSF1 6426
Affinity Capture-MS Homo sapiens
165 NPM3 10360
Affinity Capture-MS Homo sapiens
166 TJP1 7082
Affinity Capture-MS Homo sapiens
167 ISG20L2 81875
Affinity Capture-MS Homo sapiens
168 RPS6 6194
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 DCAF13 25879
Affinity Capture-MS Homo sapiens
170 SRSF5 6430
Affinity Capture-MS Homo sapiens
171 RPL3 6122
Affinity Capture-MS Homo sapiens
172 DNAJC17  
Proximity Label-MS Homo sapiens
173 RBM27  
Affinity Capture-MS Homo sapiens
174 RPL35 11224
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
175 MYC  
Affinity Capture-MS Homo sapiens
176 ZC3H10  
Affinity Capture-MS Homo sapiens
177 RFC1 5981
Affinity Capture-MS Homo sapiens
178 RP9  
Affinity Capture-MS Homo sapiens
179 SOX15  
Affinity Capture-MS Homo sapiens
180 ZNF512  
Affinity Capture-MS Homo sapiens
181 BBX 56987
Affinity Capture-MS Homo sapiens
182 RPL36 25873
Affinity Capture-MS Homo sapiens
183 DKC1 1736
Co-fractionation Homo sapiens
184 MYO6 4646
Proximity Label-MS Homo sapiens
185 PSPC1 55269
Affinity Capture-MS Homo sapiens
186 RPA3 6119
Proximity Label-MS Homo sapiens
187 RPP25  
Affinity Capture-MS Homo sapiens
188 CEBPZ  
Affinity Capture-MS Homo sapiens
189 INO80B 83444
Affinity Capture-MS Homo sapiens
190 NOL12 79159
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
191 MAP9 79884
Affinity Capture-MS Homo sapiens
192 PRRC2A 7916
Affinity Capture-MS Homo sapiens
193 RPL22 6146
Affinity Capture-MS Homo sapiens
194 FAM133B 257415
Affinity Capture-MS Homo sapiens
195 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
196 C1D  
Affinity Capture-MS Homo sapiens
197 RPL23A 6147
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
198 RPL18 6141
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
199 DDRGK1 65992
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
200 NSRP1  
Affinity Capture-MS Homo sapiens
201 ZC3HAV1 56829
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
202 LYAR 55646
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
203 H2AFB2  
Affinity Capture-MS Homo sapiens
204 MRPS17 51373
Affinity Capture-MS Homo sapiens
205 FSCN1 6624
Affinity Capture-MS Homo sapiens
206 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
207 RPL26 6154
Affinity Capture-MS Homo sapiens
208 ZC3H3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
209 DDX52  
Affinity Capture-MS Homo sapiens
210 MAP1A 4130
Affinity Capture-MS Homo sapiens
211 DDX55  
Affinity Capture-MS Homo sapiens
212 KIAA1522 57648
Affinity Capture-MS Homo sapiens
213 RSBN1L  
Affinity Capture-MS Homo sapiens
214 RPS16 6217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
215 RPL19 6143
Affinity Capture-MS Homo sapiens
216 DDX46 9879
Affinity Capture-MS Homo sapiens
217 RPL13 6137
Affinity Capture-MS Homo sapiens
218 YBX1 4904
Affinity Capture-MS Homo sapiens
219 DHX16 8449
Affinity Capture-MS Homo sapiens
220 SURF6  
Affinity Capture-MS Homo sapiens
221 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
222 RIT1 6016
Negative Genetic Homo sapiens
223 RBM34  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
224 SIRT6  
Affinity Capture-MS Homo sapiens
225 PARP1 142
Proximity Label-MS Homo sapiens
226 HMGN4  
Affinity Capture-MS Homo sapiens
227 PDGFB  
Affinity Capture-MS Homo sapiens
228 ILF3 3609
Affinity Capture-MS Homo sapiens
229 ZFC3H1 196441
Affinity Capture-MS Homo sapiens
230 FBXL6  
Affinity Capture-MS Homo sapiens
231 TP53 7157
Affinity Capture-MS Homo sapiens
232 HMMR  
Affinity Capture-MS Homo sapiens
233 NLE1 54475
Affinity Capture-MS Homo sapiens
234 MNDA 4332
Affinity Capture-MS Homo sapiens
235 APEX1 328
Proximity Label-MS Homo sapiens
236 MRPS31  
Affinity Capture-MS Homo sapiens
237 MEN1 4221
Affinity Capture-MS Homo sapiens
238 UIMC1  
Affinity Capture-MS Homo sapiens
239 DGCR8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
240 KNOP1 400506
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
241 SMURF1 57154
Affinity Capture-MS Homo sapiens
242 G3BP1 10146
Affinity Capture-MS Homo sapiens
243 MRPS15  
Affinity Capture-MS Homo sapiens
244 PTBP3 9991
Affinity Capture-MS Homo sapiens
245 NSA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
246 G3BP2 9908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
247 H2AFB3  
Affinity Capture-MS Homo sapiens
248 MRPS18C  
Affinity Capture-MS Homo sapiens
249 CENPU  
Affinity Capture-MS