Gene description for GNL2
Gene name guanine nucleotide binding protein-like 2 (nucleolar)
Gene symbol GNL2
Other names/aliases HUMAUANTIG
NGP1
Ngp-1
Nog2
Nug2
Species Homo sapiens
 Database cross references - GNL2
ExoCarta ExoCarta_29889
Entrez Gene 29889
HGNC 29925
MIM 609365
UniProt Q13823  
 GNL2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for GNL2
Molecular Function
    GTPase activity GO:0003924 NAS
    GTP binding GO:0005525 NAS
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    ribosome biogenesis GO:0042254 IBA
    metabolic process GO:0008152 NAS
    biological_process GO:0008150 ND
Subcellular Localization
    nucleus GO:0005634 TAS
    nucleolus GO:0005730 IDA
    membrane GO:0016020 IDA
 Experiment description of studies that identified GNL2 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for GNL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYAR 55646
Affinity Capture-MS Homo sapiens
2 DDX56  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GNL2 is involved
No pathways found





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