Gene description for BLM
Gene name	Bloom syndrome, RecQ helicase-like
Gene symbol	BLM
Other names/aliases	BS RECQ2 RECQL2 RECQL3
Species	Homo sapiens
Database cross references - BLM
ExoCarta	ExoCarta_641
Vesiclepedia	VP_641
Entrez Gene	641
HGNC	1058
MIM	604610
UniProt	P54132
BLM identified in sEVs derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for BLM

Molecular Function     four-way junction DNA binding GO:0000400 IDA     Y-form DNA binding GO:0000403 IDA     bubble DNA binding GO:0000405 IDA     p53 binding GO:0002039 IPI     DNA binding GO:0003677 IDA     DNA helicase activity GO:0003678 IDA     DNA helicase activity GO:0003678 IMP     DNA clamp loader activity GO:0003689 IEA     single-stranded DNA binding GO:0003697 IDA     helicase activity GO:0004386 IDA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IDA     ATP-dependent activity, acting on DNA GO:0008094 IDA     zinc ion binding GO:0008270 IDA     four-way junction helicase activity GO:0009378 IBA     four-way junction helicase activity GO:0009378 IDA     isomerase activity GO:0016853 IEA     ATP hydrolysis activity GO:0016887 IEA     double-stranded DNA helicase activity GO:0036121 IEA     identical protein binding GO:0042802 IDA     protein homodimerization activity GO:0042803 IDA     3'-5' DNA helicase activity GO:0043138 IBA     3'-5' DNA helicase activity GO:0043138 IDA     3'-5' DNA helicase activity GO:0043138 TAS     G-quadruplex DNA binding GO:0051880 IDA     forked DNA-dependent helicase activity GO:0061749 IDA     cohesin loader activity GO:0061775 IEA     telomeric D-loop binding GO:0061821 IDA     telomeric G-quadruplex DNA binding GO:0061849 IDA     chromatin extrusion motor activity GO:0140584 IEA     ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA     ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA     8-hydroxy-2'-deoxyguanosine DNA binding GO:1905773 IDA     single-stranded 3'-5' DNA helicase activity GO:1990518 IEA     DNA/DNA annealing activity GO:1990814 IDA Biological Process     regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 IMP     telomere maintenance GO:0000723 IBA     double-strand break repair via homologous recombination GO:0000724 IBA     double-strand break repair via homologous recombination GO:0000724 IDA     double-strand break repair via homologous recombination GO:0000724 NAS     DNA double-strand break processing GO:0000729 IDA     DNA replication GO:0006260 ISS     DNA unwinding involved in DNA replication GO:0006268 IBA     DNA repair GO:0006281 NAS     DNA recombination GO:0006310 NAS     chromatin remodeling GO:0006338 IEA     DNA damage response GO:0006974 IDA     DNA damage response GO:0006974 IMP     mitotic G2 DNA damage checkpoint signaling GO:0007095 IDA     response to X-ray GO:0010165 IDA     replication fork processing GO:0031297 IDA     telomere maintenance via semi-conservative replication GO:0032201 TAS     DNA duplex unwinding GO:0032508 IDA     G-quadruplex DNA unwinding GO:0044806 IBA     G-quadruplex DNA unwinding GO:0044806 IDA     G-quadruplex DNA unwinding GO:0044806 ISS     positive regulation of DNA-templated transcription GO:0045893 IDA     negative regulation of DNA recombination GO:0045910 IMP     protein complex oligomerization GO:0051259 IDA     protein homooligomerization GO:0051260 IDA     negative regulation of cell division GO:0051782 IMP     telomeric D-loop disassembly GO:0061820 IDA     resolution of DNA recombination intermediates GO:0071139 IDA     cellular response to ionizing radiation GO:0071479 IDA     cellular response to hydroxyurea GO:0072711 IDA     cellular response to camptothecin GO:0072757 IDA     regulation of DNA-templated DNA replication GO:0090329 IMP     t-circle formation GO:0090656 TAS     chromatin looping GO:0140588 IEA Subcellular Localization     nuclear chromosome GO:0000228 IDA     chromosome, telomeric region GO:0000781 IDA     lateral element GO:0000800 IDA     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleus GO:0005634 NAS     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     replication fork GO:0005657 ISS     chromosome GO:0005694 IBA     nucleolus GO:0005730 IDA     cytoplasm GO:0005737 IBA     cytosol GO:0005829 IDA     nuclear matrix GO:0016363 IDA     PML body GO:0016605 IDA     PML body GO:0016605 IDA     RecQ family helicase-topoisomerase III complex GO:0031422 IPI     protein-containing complex GO:0032991 IDA