Gene description for ADA
Gene name	adenosine deaminase
Gene symbol	ADA
Other names/aliases	-
Species	Homo sapiens
Database cross references - ADA
ExoCarta	ExoCarta_100
Entrez Gene	100
HGNC	186
MIM	608958
UniProt	P00813
ADA identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Thymus	23844026

Gene ontology annotations for ADA

Molecular Function     zinc ion binding GO:0008270 ISS     adenosine deaminase activity GO:0004000 ISS     purine nucleoside binding GO:0001883 IEA     protein binding GO:0005515 IPI Biological Process     xanthine biosynthetic process GO:0046111 IEA     positive regulation of alpha-beta T cell differentiation GO:0046638 IEA     negative regulation of mature B cell apoptotic process GO:0002906 IEA     regulation of cell-cell adhesion mediated by integrin GO:0033632 IDA     positive regulation of B cell proliferation GO:0030890 IEA     purine ribonucleoside monophosphate biosynthetic process GO:0009168 IEA     negative regulation of thymocyte apoptotic process GO:0070244 IEA     lung alveolus development GO:0048286 IEA     small molecule metabolic process GO:0044281 TAS     response to vitamin E GO:0033197 IEA     response to drug GO:0042493 IEA     negative regulation of inflammatory response GO:0050728 IEA     response to morphine GO:0043278 IEA     positive regulation of smooth muscle contraction GO:0045987 IEA     positive regulation of heart rate GO:0010460 IEA     germinal center B cell differentiation GO:0002314 IEA     negative regulation of leukocyte migration GO:0002686 IEA     response to hydrogen peroxide GO:0042542 IEA     histamine secretion GO:0001821 IEA     purine nucleotide salvage GO:0032261 IMP     nucleobase-containing small molecule metabolic process GO:0055086 TAS     dATP catabolic process GO:0046061 IEA     positive regulation of T cell differentiation in thymus GO:0033089 IEA     adenosine catabolic process GO:0006154 ISS     liver development GO:0001889 IEA     negative regulation of circadian sleep/wake cycle, non-REM sleep GO:0042323 IEA     purine nucleobase metabolic process GO:0006144 TAS     purine-containing compound salvage GO:0043101 TAS     inosine biosynthetic process GO:0046103 ISS     positive regulation of germinal center formation GO:0002636 IEA     T cell activation GO:0042110 IDA     negative regulation of penile erection GO:0060407 IEA     embryonic digestive tract development GO:0048566 IEA     positive regulation of calcium-mediated signaling GO:0050850 IEA     positive regulation of T cell receptor signaling pathway GO:0050862 IEA     Peyer's patch development GO:0048541 IEA     aging GO:0007568 IEA     placenta development GO:0001890 IEA     negative regulation of mucus secretion GO:0070256 IEA     response to hypoxia GO:0001666 IDA     trophectodermal cell differentiation GO:0001829 IEA     hypoxanthine salvage GO:0043103 IBA     negative regulation of adenosine receptor signaling pathway GO:0060169 IDA     deoxyadenosine catabolic process GO:0006157 IEA Subcellular Localization     plasma membrane GO:0005886 IDA     neuronal cell body GO:0043025 IEA     dendrite cytoplasm GO:0032839 IEA     lysosome GO:0005764 IDA     external side of plasma membrane GO:0009897 IDA     cytosol GO:0005829 TAS     membrane GO:0016020 IDA     cell junction GO:0030054 IEA     extracellular space GO:0005615 IEA     cytoplasm GO:0005737 IDA     cell surface GO:0009986 IDA     cytoplasmic membrane-bounded vesicle lumen GO:0060205 IEA