Gene description for SERPINB5
Gene name serpin peptidase inhibitor, clade B (ovalbumin), member 5
Gene symbol SERPINB5
Other names/aliases PI5
maspin
Species Homo sapiens
 Database cross references - SERPINB5
ExoCarta ExoCarta_5268
Entrez Gene 5268
HGNC 8949
MIM 154790
UniProt P36952  
 SERPINB5 identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for SERPINB5
Molecular Function
    serine-type endopeptidase inhibitor activity GO:0004867 IBA
    protein binding GO:0005515 IPI
Biological Process
    prostate gland morphogenesis GO:0060512 IEA
    morphogenesis of an epithelium GO:0002009 IEA
    movement of cell or subcellular component GO:0006928 TAS
    regulation of epithelial cell proliferation GO:0050678 IEA
    extracellular matrix organization GO:0030198 IEA
    negative regulation of endopeptidase activity GO:0010951 IBA
Subcellular Localization
    extracellular space GO:0005615 IBA
    cytoplasm GO:0005737 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified SERPINB5 in exosomes
1
Experiment ID 189
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
ISEV standards
EM
EV Biophysical techniques
HSC70
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SERPINB5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SERPINB5 is involved
No pathways found





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