Gene description for REXO2
Gene name RNA exonuclease 2
Gene symbol REXO2
Other names/aliases CGI-114
REX2
RFN
SFN
Species Homo sapiens
 Database cross references - REXO2
ExoCarta ExoCarta_25996
Vesiclepedia VP_25996
Entrez Gene 25996
HGNC 17851
MIM 607149
UniProt Q9Y3B8  
 REXO2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for REXO2
Molecular Function
    3'-5'-RNA exonuclease activity GO:0000175 IBA
    3'-5'-RNA exonuclease activity GO:0000175 IDA
    3'-5'-RNA exonuclease activity GO:0000175 IMP
    magnesium ion binding GO:0000287 IDA
    nucleic acid binding GO:0003676 IEA
    3'-5'-DNA exonuclease activity GO:0008296 IDA
    3'-5' exonuclease activity GO:0008408 IDA
    3'-5' exonuclease activity GO:0008408 IMP
Biological Process
    nucleobase-containing compound metabolic process GO:0006139 IDA
    DNA metabolic process GO:0006259 IEA
    nucleotide metabolic process GO:0009117 TAS
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial intermembrane space GO:0005758 IDA
    mitochondrial matrix GO:0005759 IDA
    mitochondrial matrix GO:0005759 TAS
    focal adhesion GO:0005925 IDA
 Experiment description of studies that identified REXO2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for REXO2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PMS2  
Co-fractionation Homo sapiens
2 CS 1431
Co-fractionation Homo sapiens
3 SNX27 81609
Affinity Capture-MS Homo sapiens
4 HSPA5 3309
Co-fractionation Homo sapiens
5 TSFM 10102
Co-fractionation Homo sapiens
6 SOD2 6648
Co-fractionation Homo sapiens
7 HTRA2 27429
Co-fractionation Homo sapiens
8 CUTA 51596
Co-fractionation Homo sapiens
9 MYL6 4637
Co-fractionation Homo sapiens
10 PITRM1 10531
Co-fractionation Homo sapiens
11 YWHAB 7529
Co-fractionation Homo sapiens
12 ABHD10 55347
Co-fractionation Homo sapiens
13 DLD 1738
Co-fractionation Homo sapiens
14 SEPHS1 22929
Co-fractionation Homo sapiens
15 NFU1 27247
Co-fractionation Homo sapiens
16 SUCLG1 8802
Co-fractionation Homo sapiens
17 RGSL1  
Co-fractionation Homo sapiens
18 ECI1 1632
Co-fractionation Homo sapiens
19 HMGCS1 3157
Co-fractionation Homo sapiens
20 SUCLA2 8803
Co-fractionation Homo sapiens
21 SERPINB5 5268
Co-fractionation Homo sapiens
22 OAT 4942
Co-fractionation Homo sapiens
23 DNAJC5 80331
Co-fractionation Homo sapiens
24 C12orf49  
Negative Genetic Homo sapiens
25 TXNDC17 84817
Co-fractionation Homo sapiens
26 MDH1 4190
Co-fractionation Homo sapiens
27 HSPD1 3329
Co-fractionation Homo sapiens
28 SCLY  
Co-fractionation Homo sapiens
29 BOD1L1 259282
Cross-Linking-MS (XL-MS) Homo sapiens
30 TYMS 7298
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which REXO2 is involved
PathwayEvidenceSource
Metabolism of RNA TAS Reactome
Mitochondrial RNA degradation TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here