Gene description for OAT
Gene name ornithine aminotransferase
Gene symbol OAT
Other names/aliases GACR
HOGA
OATASE
OKT
Species Homo sapiens
 Database cross references - OAT
ExoCarta ExoCarta_4942
Entrez Gene 4942
HGNC 8091
MIM 613349
UniProt P04181  
 OAT identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for OAT
Molecular Function
    ornithine-oxo-acid transaminase activity GO:0004587 EXP
    pyridoxal phosphate binding GO:0030170 IEA
Biological Process
    cellular amino acid biosynthetic process GO:0008652 TAS
    protein hexamerization GO:0034214 IDA
    small molecule metabolic process GO:0044281 TAS
    L-proline biosynthetic process GO:0055129 IEA
    visual perception GO:0007601 TAS
    cellular nitrogen compound metabolic process GO:0034641 TAS
Subcellular Localization
    mitochondrial matrix GO:0005759 TAS
    mitochondrion GO:0005739 TAS
 Experiment description of studies that identified OAT in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for OAT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 OAT 4942
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
2 EIF6 3692
Affinity Capture-MS Homo sapiens
3 SLC35F6 54978
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which OAT is involved
PathwayEvidenceSource
Amino acid synthesis and interconversion (transamination) TAS Reactome





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