Gene description for POF1B
Gene name premature ovarian failure, 1B
Gene symbol POF1B
Other names/aliases POF
POF2B
Species Homo sapiens
 Database cross references - POF1B
ExoCarta ExoCarta_79983
Vesiclepedia VP_79983
Entrez Gene 79983
HGNC 13711
MIM 300603
UniProt Q8WVV4  
 POF1B identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 34887515    
 Gene ontology annotations for POF1B
Molecular Function
    protein binding GO:0005515 IPI
    actin filament binding GO:0051015 IBA
    actin filament binding GO:0051015 IMP
Biological Process
    epithelial cell morphogenesis GO:0003382 IBA
    epithelial cell morphogenesis GO:0003382 IMP
    actin filament organization GO:0007015 IBA
    actin filament organization GO:0007015 IMP
    actin cytoskeleton organization GO:0030036 IMP
    bicellular tight junction assembly GO:0070830 IBA
    bicellular tight junction assembly GO:0070830 IMP
Subcellular Localization
    actin filament GO:0005884 IBA
    actin filament GO:0005884 IDA
    adherens junction GO:0005912 IBA
    adherens junction GO:0005912 IDA
    bicellular tight junction GO:0005923 IBA
    bicellular tight junction GO:0005923 IDA
    desmosome GO:0030057 IDA
 Experiment description of studies that identified POF1B in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
 Protein-protein interactions for POF1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 BPHL 670
Affinity Capture-MS Homo sapiens
3 Cdk1 12534
Affinity Capture-MS Mus musculus
4 FRS3 10817
Two-hybrid Homo sapiens
5 ZNF645  
Affinity Capture-MS Homo sapiens
6 Tpr 108989
Affinity Capture-MS Mus musculus
7 RTCA 8634
Affinity Capture-MS Homo sapiens
8 TPM2 7169
Affinity Capture-MS Homo sapiens
9 Akap12  
Affinity Capture-MS Mus musculus
10 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 RAB9B 51209
Affinity Capture-MS Homo sapiens
12 EBF2  
Affinity Capture-MS Homo sapiens
13 RANBP3 8498
Affinity Capture-MS Homo sapiens
14 PLAC8L1  
Affinity Capture-MS Homo sapiens
15 SOX2  
Affinity Capture-MS Homo sapiens
16 FNDC5  
Affinity Capture-MS Homo sapiens
17 PI4KA 5297
Affinity Capture-MS Homo sapiens
18 RHBDD1 84236
Affinity Capture-MS Homo sapiens
19 KAT7  
Affinity Capture-MS Homo sapiens
20 DPPA4  
Affinity Capture-MS Homo sapiens
21 HRC  
Affinity Capture-MS Homo sapiens
22 PPL 5493
Two-hybrid Homo sapiens
23 GPATCH2L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 Lyplal1  
Affinity Capture-MS Mus musculus
25 B3GNT2 10678
Affinity Capture-MS Homo sapiens
26 ZDHHC19  
Affinity Capture-MS Homo sapiens
27 CA8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 SOSTDC1  
Affinity Capture-MS Homo sapiens
29 COPS5 10987
Affinity Capture-MS Homo sapiens
30 FBXW7  
Affinity Capture-MS Homo sapiens
31 NUDT3 11165
Affinity Capture-MS Homo sapiens
32 COL8A1 1295
Two-hybrid Homo sapiens
33 CEMIP 57214
Affinity Capture-MS Homo sapiens
34 OR13C3  
Affinity Capture-MS Homo sapiens
35 FMNL2 114793
Affinity Capture-MS Homo sapiens
36 MMP14 4323
Affinity Capture-MS Homo sapiens
37 THAP10  
Affinity Capture-MS Homo sapiens
38 TCEB3B  
Affinity Capture-MS Homo sapiens
39 UCHL5 51377
Reconstituted Complex Homo sapiens
40 PHF11 51131
Affinity Capture-MS Homo sapiens
41 FNDC1 84624
Affinity Capture-MS Homo sapiens
42 SFN 2810
Affinity Capture-MS Homo sapiens
43 Fam134a  
Affinity Capture-MS Mus musculus
44 PGK2 5232
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 IFNA4  
Affinity Capture-MS Homo sapiens
46 CCNC  
Affinity Capture-MS Homo sapiens
47 C18orf21  
Affinity Capture-MS Homo sapiens
48 NDUFS5 4725
Affinity Capture-MS Homo sapiens
49 FCF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 KLHL38  
Two-hybrid Homo sapiens
51 DDX19B 11269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 ACTA2 59
Affinity Capture-MS Homo sapiens
53 ZNF550  
Affinity Capture-MS Homo sapiens
54 DPEP2  
Affinity Capture-MS Homo sapiens
55 RNF4 6047
Affinity Capture-MS Homo sapiens
56 CCNYL1 151195
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
58 LRRC10  
Affinity Capture-MS Homo sapiens
59 PLK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 MYCBPAP 84073
Affinity Capture-MS Homo sapiens
61 EIF2B5 8893
Affinity Capture-MS Homo sapiens
62 DEFB106A  
Affinity Capture-MS Homo sapiens
63 ASCL1  
Affinity Capture-MS Homo sapiens
64 ARL4A  
Two-hybrid Homo sapiens
65 ZCCHC17  
Affinity Capture-MS Homo sapiens
66 CCDC51 79714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 JADE1  
Affinity Capture-MS Homo sapiens
68 GEM  
Two-hybrid Homo sapiens
69 TRIM21 6737
Affinity Capture-MS Homo sapiens
70 SARAF  
Affinity Capture-MS Homo sapiens
71 PIGT 51604
Affinity Capture-MS Homo sapiens
72 IQUB  
Affinity Capture-MS Homo sapiens
73 CDH1 999
Proximity Label-MS Homo sapiens
74 SSUH2  
Affinity Capture-MS Homo sapiens
75 BCL6  
Two-hybrid Homo sapiens
76 FGFRL1 53834
Affinity Capture-MS Homo sapiens
77 RFPL3  
Two-hybrid Homo sapiens
78 HCN1  
Affinity Capture-MS Homo sapiens
79 APTX  
Affinity Capture-MS Homo sapiens
80 AQP12B  
Affinity Capture-MS Homo sapiens
81 DDX39B 7919
Affinity Capture-MS Homo sapiens
82 SCN3B  
Affinity Capture-MS Homo sapiens
83 APIP 51074
Affinity Capture-MS Homo sapiens
84 CYLD  
Affinity Capture-MS Homo sapiens
85 FSTL1 11167
Affinity Capture-MS Homo sapiens
86 ACD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 CASP14 23581
Affinity Capture-MS Homo sapiens
88 DTL  
Affinity Capture-MS Homo sapiens
89 IGFN1  
Two-hybrid Homo sapiens
90 SERPINB3 6317
Affinity Capture-MS Homo sapiens
91 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
92 GFER  
Affinity Capture-MS Homo sapiens
93 IVL 3713
Affinity Capture-MS Homo sapiens
94 FANCD2  
Affinity Capture-MS Homo sapiens
95 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
96 AGPAT1 10554
Affinity Capture-MS Homo sapiens
97 KCTD9  
Two-hybrid Homo sapiens
98 C16orf70  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 ZSCAN20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 NKAIN3  
Affinity Capture-MS Homo sapiens
102 MOGAT3  
Affinity Capture-MS Homo sapiens
103 SLC35F2 54733
Affinity Capture-MS Homo sapiens
104 ZSCAN12  
Affinity Capture-MS Homo sapiens
105 NPPA  
Affinity Capture-MS Homo sapiens
106 ZC3HC1  
Affinity Capture-MS Homo sapiens
107 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
108 FTH1 2495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 LGALS7 3963
Affinity Capture-MS Homo sapiens
110 EHBP1 23301
Affinity Capture-MS Homo sapiens
111 C21orf59 56683
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 SYT17  
Two-hybrid Homo sapiens
113 CTSD 1509
Affinity Capture-MS Homo sapiens
114 TSPAN8 7103
Affinity Capture-MS Homo sapiens
115 PI4KAP1  
Affinity Capture-MS Homo sapiens
116 FAM90A1  
Two-hybrid Homo sapiens
117 COA5  
Affinity Capture-MS Homo sapiens
118 PROK2  
Affinity Capture-MS Homo sapiens
119 BLMH 642
Affinity Capture-MS Homo sapiens
120 ACAD9 28976
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 GMCL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 SLC37A4 2542
Affinity Capture-MS Homo sapiens
123 STX17 55014
Affinity Capture-MS Homo sapiens
124 PFDN5 5204
Affinity Capture-MS Homo sapiens
125 RIPPLY3  
Affinity Capture-MS Homo sapiens
126 SERPINB5 5268
Affinity Capture-MS Homo sapiens
127 G3BP1 10146
Affinity Capture-MS Homo sapiens
128 PRSS16 10279
Affinity Capture-MS Homo sapiens
129 SPICE1  
Affinity Capture-MS Homo sapiens
130 ADH1C 126
Affinity Capture-MS Homo sapiens
131 STK16 8576
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 SLC25A6 293
Affinity Capture-MS Homo sapiens
133 FBXL6  
Affinity Capture-MS Homo sapiens
134 SCGB1D1  
Affinity Capture-MS Homo sapiens
135 POLR2L 5441
Affinity Capture-MS Homo sapiens
136 EIF1AX 1964
Affinity Capture-MS Homo sapiens
137 SH2D3A  
Affinity Capture-MS Homo sapiens
138 CHST10  
Affinity Capture-MS Homo sapiens
139 NHLRC2 374354
Affinity Capture-MS Homo sapiens
140 C1orf35  
Affinity Capture-MS Homo sapiens
141 PTDSS1 9791
Affinity Capture-MS Homo sapiens
142 ZDHHC23  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 MS4A6E  
Affinity Capture-MS Homo sapiens
144 PKP1 5317
Affinity Capture-MS Homo sapiens
145 KLHL11  
Affinity Capture-MS Homo sapiens
146 ESR1  
Affinity Capture-MS Homo sapiens
147 ERCC3  
Affinity Capture-MS Homo sapiens
148 MBNL1 4154
Affinity Capture-MS Homo sapiens
149 KIR3DS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
150 CALML5 51806
Affinity Capture-MS Homo sapiens
151 TEFM  
Affinity Capture-MS Homo sapiens
152 GPR18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
153 GOT1 2805
Affinity Capture-MS Homo sapiens
154 STK11 6794
Affinity Capture-MS Homo sapiens
155 PDE4DIP 9659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
156 SKA3  
Affinity Capture-MS Homo sapiens
157 OR2A4 79541
Affinity Capture-MS Homo sapiens
158 E2F6 1876
Affinity Capture-MS Homo sapiens
159 GABPA 2551
Affinity Capture-MS Homo sapiens
160 CCR1  
Affinity Capture-MS Homo sapiens
161 P2RX6  
Affinity Capture-MS Homo sapiens
162 CSGALNACT1 55790
Affinity Capture-MS Homo sapiens
163 CUL4A 8451
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which POF1B is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here