Gene description for NDUFS5
Gene name NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
Gene symbol NDUFS5
Other names/aliases CI-15k
CI15K
Species Homo sapiens
 Database cross references - NDUFS5
ExoCarta ExoCarta_4725
Entrez Gene 4725
HGNC 7712
MIM 603847
UniProt O43920  
 NDUFS5 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for NDUFS5
Molecular Function
    NADH dehydrogenase (ubiquinone) activity GO:0008137 NAS
Biological Process
    small molecule metabolic process GO:0044281 TAS
    respiratory electron transport chain GO:0022904 TAS
    cellular metabolic process GO:0044237 TAS
    mitochondrial respiratory chain complex I assembly GO:0032981 IMP
    mitochondrial electron transport, NADH to ubiquinone GO:0006120 NAS
Subcellular Localization
    mitochondrion GO:0005739 IDA
    mitochondrial respiratory chain complex I GO:0005747 NAS
    mitochondrial intermembrane space GO:0005758 IEA
    mitochondrial inner membrane GO:0005743 TAS
 Experiment description of studies that identified NDUFS5 in exosomes
1
Experiment ID 236
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for NDUFS5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which NDUFS5 is involved
PathwayEvidenceSource
Respiratory electron transport TAS Reactome





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