Gene description for CYC1
Gene name cytochrome c-1
Gene symbol CYC1
Other names/aliases MC3DN6
UQCR4
Species Homo sapiens
 Database cross references - CYC1
ExoCarta ExoCarta_1537
Entrez Gene 1537
HGNC 2579
MIM 123980
UniProt P08574  
 CYC1 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for CYC1
Molecular Function
    heme binding GO:0020037 IEA
    metal ion binding GO:0046872 IEA
    electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity GO:0045155 TAS
Biological Process
    small molecule metabolic process GO:0044281 TAS
    response to glucagon GO:0033762 IEA
    cellular metabolic process GO:0044237 TAS
    respiratory electron transport chain GO:0022904 TAS
Subcellular Localization
    respiratory chain GO:0070469 IEA
    membrane GO:0016020 IDA
    integral component of membrane GO:0016021 IEA
    nucleus GO:0005634 IDA
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified CYC1 in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CYC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CYCS  
Biochemical Activity Homo sapiens
View the network image/svg+xml
 Pathways in which CYC1 is involved
PathwayEvidenceSource
Mitochondrial protein import TAS Reactome
Respiratory electron transport TAS Reactome





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