Gene description for PEX19
Gene name peroxisomal biogenesis factor 19
Gene symbol PEX19
Other names/aliases D1S2223E
HK33
PBD12A
PMP1
PMPI
PXF
PXMP1
Species Homo sapiens
 Database cross references - PEX19
ExoCarta ExoCarta_5824
Vesiclepedia VP_5824
Entrez Gene 5824
HGNC 9713
MIM 600279
UniProt P40855  
 PEX19 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PEX19
Molecular Function
    peroxisome membrane class-1 targeting sequence binding GO:0036105 IDA
    protein binding GO:0005515 IPI
    ATPase binding GO:0051117 IPI
    protein N-terminus binding GO:0047485 IPI
Biological Process
    peroxisome membrane biogenesis GO:0016557 IDA
    negative regulation of lipid binding GO:1900131 IDA
    protein import into peroxisome membrane GO:0045046 IDA
    peroxisome fission GO:0016559 IMP
    peroxisome organization GO:0007031 NAS
    protein targeting to peroxisome GO:0006625 IMP
    chaperone-mediated protein folding GO:0061077 IDA
    establishment of protein localization to peroxisome GO:0072663 IMP
    chaperone-mediated protein transport GO:0072321 IDA
    transmembrane transport GO:0055085 TAS
    protein stabilization GO:0050821 IDA
Subcellular Localization
    integral component of membrane GO:0016021 IDA
    peroxisomal membrane GO:0005778 IDA
    brush border membrane GO:0031526 ISS
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 ISS
    peroxisome GO:0005777 ISS
    nucleus GO:0005634 IMP
    nucleoplasm GO:0005654 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    protein complex GO:0043234 IDA
 Experiment description of studies that identified PEX19 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PEX19
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PEX14 5195
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
2 PMP22  
Affinity Capture-MS Homo sapiens
3 PEX13  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
4 SLC25A17 10478
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
5 ABCD3 5825
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
6 PEX16 9409
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
7 PEX11B 8799
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
8 PEX12  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
9 PEX10  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
10 PEX3 8504
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
11 PEX11A  
Affinity Capture-MS Homo sapiens
12 ABCD2 225
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
13 ABCD1 215
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PEX19 is involved
PathwayEvidenceSource
ABCA transporters in lipid homeostasis TAS Reactome





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