Gene description for NAT8L
Gene name N-acetyltransferase 8-like (GCN5-related, putative)
Gene symbol NAT8L
Other names/aliases CML3
NACED
NAT8-LIKE
Species Homo sapiens
 Database cross references - NAT8L
ExoCarta ExoCarta_339983
Entrez Gene 339983
HGNC 26742
MIM 610647
UniProt Q8N9F0  
 NAT8L identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for NAT8L
Molecular Function
    aspartate N-acetyltransferase activity GO:0017188 IDA
Biological Process
    metabolic process GO:0008152 IEA
    positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 IEA
Subcellular Localization
    rough endoplasmic reticulum membrane GO:0030867 IEA
    integral component of membrane GO:0016021 IEA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IDA
    mitochondrial membrane GO:0031966 IDA
 Experiment description of studies that identified NAT8L in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for NAT8L
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which NAT8L is involved
No pathways found





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