Gene description for ABCD2
Gene name ATP-binding cassette, sub-family D (ALD), member 2
Gene symbol ABCD2
Other names/aliases ABC39
ALDL1
ALDR
ALDRP
hALDR
Species Homo sapiens
 Database cross references - ABCD2
ExoCarta ExoCarta_225
Entrez Gene 225
HGNC 66
MIM 601081
UniProt Q9UBJ2  
 ABCD2 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for ABCD2
Molecular Function
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    ATPase activity, coupled to transmembrane movement of substances GO:0042626 IEA
    protein homodimerization activity GO:0042803 IDA
Biological Process
    fatty acid beta-oxidation GO:0006635 IGI
    very long-chain fatty acid metabolic process GO:0000038 IDA
    positive regulation of fatty acid beta-oxidation GO:0032000 IDA
    very long-chain fatty acid catabolic process GO:0042760 IGI
    transmembrane transport GO:0055085 TAS
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
    cytosol GO:0005829 TAS
    mitochondrion GO:0005739 IEA
    peroxisome GO:0005777 IDA
    peroxisomal membrane GO:0005778 TAS
 Experiment description of studies that identified ABCD2 in exosomes
1
Experiment ID 274
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for ABCD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PEX19  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
2 ABCD1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ABCD2 is involved
PathwayEvidenceSource
ABCA transporters in lipid homeostasis TAS Reactome





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