Gene description for ABCD1
Gene name ATP-binding cassette, sub-family D (ALD), member 1
Gene symbol ABCD1
Other names/aliases ABC42
ALD
ALDP
AMN
Species Homo sapiens
 Database cross references - ABCD1
ExoCarta ExoCarta_215
Vesiclepedia VP_215
Entrez Gene 215
HGNC 61
MIM 300371
UniProt P33897  
 ABCD1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ABCD1
Molecular Function
    long-chain fatty acid transmembrane transporter activity GO:0005324 EXP
    long-chain fatty acid transmembrane transporter activity GO:0005324 IBA
    long-chain fatty acid transmembrane transporter activity GO:0005324 IGI
    long-chain fatty acid transmembrane transporter activity GO:0005324 TAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IBA
    ATP binding GO:0005524 IDA
    ABC-type fatty-acyl-CoA transporter activity GO:0015607 IDA
    ABC-type fatty-acyl-CoA transporter activity GO:0015607 IGI
    ATP hydrolysis activity GO:0016887 IDA
    enzyme binding GO:0019899 IPI
    ATPase-coupled transmembrane transporter activity GO:0042626 IBA
    ATPase-coupled transmembrane transporter activity GO:0042626 IDA
    ATPase-coupled transmembrane transporter activity GO:0042626 NAS
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
    ADP binding GO:0043531 IDA
    protein heterodimerization activity GO:0046982 IEA
    fatty acyl-CoA hydrolase activity GO:0047617 IDA
    very long-chain fatty acyl-CoA hydrolase activity GO:0052817 IEA
Biological Process
    very long-chain fatty acid metabolic process GO:0000038 IDA
    regulation of oxidative phosphorylation GO:0002082 ISS
    fatty acid beta-oxidation GO:0006635 IBA
    fatty acid beta-oxidation GO:0006635 IDA
    fatty acid beta-oxidation GO:0006635 IGI
    fatty acid beta-oxidation GO:0006635 IMP
    peroxisome organization GO:0007031 IBA
    peroxisome organization GO:0007031 IDA
    peroxisome organization GO:0007031 NAS
    long-chain fatty acid import into peroxisome GO:0015910 IBA
    long-chain fatty acid import into peroxisome GO:0015910 IGI
    fatty-acyl-CoA transport GO:0015916 IEA
    peroxisomal membrane transport GO:0015919 NAS
    fatty acid elongation GO:0030497 ISS
    regulation of fatty acid beta-oxidation GO:0031998 ISS
    positive regulation of fatty acid beta-oxidation GO:0032000 IMP
    positive regulation of fatty acid beta-oxidation GO:0032000 ISS
    alpha-linolenic acid metabolic process GO:0036109 TAS
    very long-chain fatty-acyl-CoA catabolic process GO:0036113 IMP
    long-chain fatty acid catabolic process GO:0042758 IGI
    long-chain fatty acid catabolic process GO:0042758 IMP
    very long-chain fatty acid catabolic process GO:0042760 IBA
    very long-chain fatty acid catabolic process GO:0042760 IDA
    very long-chain fatty acid catabolic process GO:0042760 IGI
    myelin maintenance GO:0043217 ISS
    linoleic acid metabolic process GO:0043651 TAS
    regulation of mitochondrial depolarization GO:0051900 ISS
    fatty acid homeostasis GO:0055089 ISS
    sterol homeostasis GO:0055092 ISS
    negative regulation of cytokine production involved in inflammatory response GO:1900016 ISS
    regulation of cellular response to oxidative stress GO:1900407 ISS
    negative regulation of reactive oxygen species biosynthetic process GO:1903427 ISS
    neuron projection maintenance GO:1990535 ISS
    positive regulation of unsaturated fatty acid biosynthetic process GO:2001280 ISS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    lysosomal membrane GO:0005765 IDA
    peroxisome GO:0005777 IDA
    peroxisomal membrane GO:0005778 IBA
    peroxisomal membrane GO:0005778 IDA
    peroxisomal membrane GO:0005778 NAS
    peroxisomal membrane GO:0005778 TAS
    endoplasmic reticulum membrane GO:0005789 IDA
    cytosol GO:0005829 TAS
    membrane GO:0016020 HDA
    mitochondrial membrane GO:0031966 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified ABCD1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ABCD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPSA 3921
Two-hybrid Homo sapiens
2 SLC39A12  
Affinity Capture-MS Homo sapiens
3 ANLN 54443
Affinity Capture-MS Homo sapiens
4 POT1  
Affinity Capture-MS Homo sapiens
5 IMMT 10989
Co-fractionation Homo sapiens
6 Rab5c 19345
Affinity Capture-MS Mus musculus
7 KIF23 9493
Affinity Capture-MS Homo sapiens
8 SLC15A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TERF2  
Affinity Capture-MS Homo sapiens
10 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 VAPA 9218
Affinity Capture-MS Homo sapiens
12 TTYH1  
Affinity Capture-MS Homo sapiens
13 MAS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 CMTM5  
Affinity Capture-MS Homo sapiens
15 NDUFS1 4719
Co-fractionation Homo sapiens
16 SLC39A4 55630
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CMTM8  
Affinity Capture-MS Homo sapiens
18 ECT2 1894
Affinity Capture-MS Homo sapiens
19 PEX19 5824
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
20 DYNC1I2 1781
Affinity Capture-MS Homo sapiens
21 BSG 682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 FAM96A  
Affinity Capture-MS Homo sapiens
23 S100A2 6273
Affinity Capture-MS Homo sapiens
24 CRELD1 78987
Affinity Capture-MS Homo sapiens
25 MGARP  
Affinity Capture-MS Homo sapiens
26 GPR12  
Affinity Capture-MS Homo sapiens
27 KIF20A 10112
Affinity Capture-MS Homo sapiens
28 NDUFA12 55967
Co-fractionation Homo sapiens
29 ELAVL1 1994
Co-fractionation Homo sapiens
30 ITPR3 3710
Co-fractionation Homo sapiens
31 FBXO6 26270
Affinity Capture-MS Homo sapiens
32 IQCF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 CHCHD3 54927
Co-fractionation Homo sapiens
34 KIF14 9928
Affinity Capture-MS Homo sapiens
35 SAAL1 113174
Affinity Capture-MS Homo sapiens
36 BCL2  
Affinity Capture-MS Homo sapiens
37 PBXIP1 57326
Affinity Capture-MS Homo sapiens
38 VPS26B 112936
Affinity Capture-MS Homo sapiens
39 ATP2A1 487
Affinity Capture-MS Homo sapiens
40 NTRK1 4914
Affinity Capture-MS Homo sapiens
41 RAB7A 7879
Affinity Capture-MS Homo sapiens
42 ATP2B2 491
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 GPR182  
Affinity Capture-MS Homo sapiens
44 METTL21B  
Affinity Capture-MS Homo sapiens
45 TMEM9 252839
Affinity Capture-MS Homo sapiens
46 B3GNT2 10678
Affinity Capture-MS Homo sapiens
47 SLC27A2 11001
Protein-peptide Homo sapiens
Two-hybrid Homo sapiens
48 ABCD3 5825
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
49 VASN 114990
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 FSCN1 6624
Affinity Capture-MS Homo sapiens
51 AGPS 8540
Co-fractionation Homo sapiens
52 PEX3 8504
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
53 SCN3B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 ATP2A3 489
Affinity Capture-MS Homo sapiens
55 AKAP1 8165
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 NDUFB4 4710
Co-fractionation Homo sapiens
57 Slc27a2  
Protein-peptide Rattus norvegicus
58 ABCD2 225
Two-hybrid Homo sapiens
59 BACE2 25825
Affinity Capture-MS Homo sapiens
60 CTLA4  
Affinity Capture-MS Homo sapiens
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