Gene description for ABCD1
Gene name ATP-binding cassette, sub-family D (ALD), member 1
Gene symbol ABCD1
Other names/aliases ABC42
ALD
ALDP
AMN
Species Homo sapiens
 Database cross references - ABCD1
ExoCarta ExoCarta_215
Vesiclepedia VP_215
Entrez Gene 215
HGNC 61
MIM 300371
UniProt P33897  
 ABCD1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ABCD1
Molecular Function
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
    protein binding GO:0005515 IPI
    transporter activity GO:0005215 NAS
    ATPase activity GO:0016887 IDA
    peroxisomal fatty-acyl-CoA transporter activity GO:0005325 TAS
    ATP binding GO:0005524 IDA
    ATPase activity, coupled to transmembrane movement of substances GO:0042626 NAS
    enzyme binding GO:0019899 IPI
Biological Process
    fatty acid beta-oxidation using acyl-CoA oxidase GO:0033540 TAS
    peroxisomal membrane transport GO:0015919 NAS
    cellular lipid metabolic process GO:0044255 TAS
    alpha-linolenic acid metabolic process GO:0036109 TAS
    peroxisome organization GO:0007031 NAS
    fatty acid beta-oxidation GO:0006635 IGI
    unsaturated fatty acid metabolic process GO:0033559 TAS
    small molecule metabolic process GO:0044281 TAS
    transmembrane transport GO:0055085 TAS
    very long-chain fatty acid catabolic process GO:0042760 IGI
    linoleic acid metabolic process GO:0043651 TAS
    long-chain fatty acid catabolic process GO:0042758 IGI
    peroxisomal long-chain fatty acid import GO:0015910 IGI
Subcellular Localization
    cytoplasm GO:0005737 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    membrane GO:0016020 IDA
    cytosol GO:0005829 TAS
    peroxisomal membrane GO:0005778 TAS
    peroxisome GO:0005777 IDA
    integral component of peroxisomal membrane GO:0005779 NAS
    mitochondrion GO:0005739 IEA
 Experiment description of studies that identified ABCD1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ABCD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ABCD3 5825
Two-hybrid Homo sapiens
2 ABCD2 225
Two-hybrid Homo sapiens
3 PEX19 5824
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml



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