Gene description for PEX11B
Gene name peroxisomal biogenesis factor 11 beta
Gene symbol PEX11B
Other names/aliases PEX11-BETA
PEX14B
Species Homo sapiens
 Database cross references - PEX11B
ExoCarta ExoCarta_8799
Vesiclepedia VP_8799
Entrez Gene 8799
HGNC 8853
MIM 603867
UniProt O96011  
 PEX11B identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PEX11B
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
Biological Process
    peroxisome organization GO:0007031 IDA
    peroxisome organization GO:0007031 ISS
    signal transduction GO:0007165 ISS
    peroxisome fission GO:0016559 IBA
    peroxisome fission GO:0016559 IDA
    regulation of peroxisome size GO:0044375 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 IEA
    peroxisome GO:0005777 IDA
    peroxisomal membrane GO:0005778 IBA
    peroxisomal membrane GO:0005778 IDA
    peroxisomal membrane GO:0005778 ISS
    peroxisomal membrane GO:0005778 TAS
    cytosol GO:0005829 TAS
    membrane GO:0016020 HDA
    protein-containing complex GO:0032991 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified PEX11B in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PEX11B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYPD3 27076
Affinity Capture-MS Homo sapiens
2 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
3 OCIAD1 54940
Proximity Label-MS Homo sapiens
4 PEX11B 8799
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 FAF2 23197
Affinity Capture-MS Homo sapiens
6 PEX19 5824
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Two-hybrid Homo sapiens
7 PXMP2  
Proximity Label-MS Homo sapiens
8 CRELD1 78987
Affinity Capture-MS Homo sapiens
9 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
10 COPE 11316
Affinity Capture-MS Homo sapiens
11 PEX11G  
Affinity Capture-Western Homo sapiens
12 KIAA1467 57613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 HTT 3064
Two-hybrid Homo sapiens
14 SAAL1 113174
Affinity Capture-MS Homo sapiens
15 DNM1L 10059
Phenotypic Enhancement Homo sapiens
16 FIS1 51024
Phenotypic Suppression Homo sapiens
Affinity Capture-Western Homo sapiens
17 SYCE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 HECW2  
Affinity Capture-MS Homo sapiens
19 COQ9  
Affinity Capture-MS Homo sapiens
20 BIN3 55909
Affinity Capture-MS Homo sapiens
21 RAB5C 5878
Proximity Label-MS Homo sapiens
22 MARCH5  
Proximity Label-MS Homo sapiens
23 ABCA2 20
Affinity Capture-MS Homo sapiens
24 LMNA 4000
Proximity Label-MS Homo sapiens
25 PEX3 8504
Proximity Label-MS Homo sapiens
26 RHOT2 89941
Proximity Label-MS Homo sapiens
27 AKAP1 8165
Proximity Label-MS Homo sapiens
28 ACBD5 91452
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PEX11B is involved
PathwayEvidenceSource
Class I peroxisomal membrane protein import TAS Reactome
Protein localization TAS Reactome





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