Gene description for LYPD3
Gene name LY6/PLAUR domain containing 3
Gene symbol LYPD3
Other names/aliases C4.4A
Species Homo sapiens
 Database cross references - LYPD3
ExoCarta ExoCarta_27076
Vesiclepedia VP_27076
Entrez Gene 27076
HGNC 24880
MIM 609484
UniProt O95274  
 LYPD3 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
Prostate cancer cells 25844599    
 Gene ontology annotations for LYPD3
Molecular Function
    laminin binding GO:0043236 IEA
Biological Process
    cell-matrix adhesion GO:0007160 IEA
    negative regulation of smooth muscle cell apoptotic process GO:0034392 IGI
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    side of membrane GO:0098552 IEA
 Experiment description of studies that identified LYPD3 in exosomes
1
Experiment ID 226
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD9|FLOT1
Enriched markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
2
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for LYPD3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DPY19L1 23333
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 ATR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CLCN7 1186
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 MTX1 4580
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 BZW2 28969
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 KIF20A 10112
Affinity Capture-MS Homo sapiens
7 LMBR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TMEM67 91147
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 PTPN1 5770
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 LAPTM4B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 EBP  
Affinity Capture-MS Homo sapiens
12 QSOX2 169714
Affinity Capture-MS Homo sapiens
13 HEATR3 55027
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 STRN 6801
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 Trim69  
Affinity Capture-MS Mus musculus
16 KIF23 9493
Affinity Capture-MS Homo sapiens
17 SLC41A1 254428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 BRAT1 221927
Affinity Capture-MS Homo sapiens
19 NR2F2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 ORC5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 ARFIP2 23647
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 BOD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 XPO7 23039
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 HELLS 3070
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 UBE2Q1 55585
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 TOMM40 10452
Affinity Capture-MS Homo sapiens
27 BTAF1 9044
Affinity Capture-MS Homo sapiens
28 FASTKD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 GNPAT 8443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CLDND1 56650
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 PDS5B 23047
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 CLASP2 23122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 USP22 23326
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 KIAA1715 80856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 MTCH2 23788
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 SYMPK 8189
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 TMEM126A 84233
Affinity Capture-MS Homo sapiens
38 MOS 4342
Affinity Capture-MS Homo sapiens
39 CLCN3 1182
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 KIAA1161 57462
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 TMC4  
Affinity Capture-MS Homo sapiens
42 SLC44A1 23446
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 DCUN1D5 84259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 TNPO2 30000
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PDS5A 23244
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 GDPD5 81544
Affinity Capture-MS Homo sapiens
47 CKAP5 9793
Affinity Capture-MS Homo sapiens
48 PIGT 51604
Affinity Capture-MS Homo sapiens
49 SLC9A1 6548
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 TPI1 7167
Co-fractionation Homo sapiens
51 PHTF1 10745
Affinity Capture-MS Homo sapiens
52 AGR2 10551
Two-hybrid Homo sapiens
53 CIB1 10519
Affinity Capture-MS Homo sapiens
54 PIGS 94005
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 ATP2B4 493
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 C16orf58 64755
Affinity Capture-MS Homo sapiens
57 BZW1 9689
Affinity Capture-MS Homo sapiens
58 COMMD9 29099
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 ANLN 54443
Affinity Capture-MS Homo sapiens
60 PLAA 9373
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 QSOX1 5768
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 GPAA1 8733
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 TARBP1 6894
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 TRAPPC3 27095
Affinity Capture-MS Homo sapiens
65 ECT2 1894
Affinity Capture-MS Homo sapiens
66 SCAMP1 9522
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 ENDOD1 23052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 TNPO3 23534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 AAAS 8086
Affinity Capture-MS Homo sapiens
70 TMEM194A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 HSDL1 83693
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 GHITM 27069
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 HIP1R 9026
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 LPAR1 1902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 XPO6 23214
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 SLC35B2 347734
Affinity Capture-MS Homo sapiens
77 PHTF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 RBM26 64062
Affinity Capture-MS Homo sapiens
79 GBF1 8729
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 MTOR 2475
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 MSLN 10232
Affinity Capture-MS Homo sapiens
82 USP24 23358
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 SLC30A7 148867
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 KIAA0368 23392
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 THADA 63892
Affinity Capture-MS Homo sapiens
86 KIAA0195 9772
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 FLVCR1 28982
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 SEL1L3  
Affinity Capture-MS Homo sapiens
89 GALNT10 55568
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 PEX11B 8799
Affinity Capture-MS Homo sapiens
91 VDAC3 7419
Affinity Capture-MS Homo sapiens
92 KIF14 9928
Affinity Capture-MS Homo sapiens
93 TRAPPC5 126003
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 SLMAP 7871
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 TMEM214 54867
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 PIGA  
Affinity Capture-MS Homo sapiens
97 SEC11A 23478
Affinity Capture-MS Homo sapiens
98 DNAAF5 54919
Affinity Capture-MS Homo sapiens
99 PIGK 10026
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 PIGU 128869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 AGR3 155465
Two-hybrid Homo sapiens
102 DDX58 23586
Affinity Capture-RNA Homo sapiens
103 NCAPD2 9918
Affinity Capture-MS Homo sapiens
104 TTI2 80185
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 TBRG4 9238
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 SPCS1 28972
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 NDC1 55706
Affinity Capture-MS Homo sapiens
108 REEP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 DNM3 26052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 NCEH1 57552
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 ASPHD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 C2CD5 9847
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 RFT1 91869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 WFS1 7466
Affinity Capture-MS Homo sapiens
115 ATP11C 286410
Affinity Capture-MS Homo sapiens
116 CKAP4 10970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 SCAMP3 10067
Affinity Capture-MS Homo sapiens
118 ELOVL4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 C17orf59 54785
Affinity Capture-MS Homo sapiens
120 TMEM245 23731
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 DNAJC22  
Affinity Capture-MS Homo sapiens
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