Gene description for MSLN
Gene name mesothelin
Gene symbol MSLN
Other names/aliases MPF
SMRP
Species Homo sapiens
 Database cross references - MSLN
ExoCarta ExoCarta_10232
Entrez Gene 10232
HGNC 7371
MIM 601051
UniProt Q13421  
 MSLN identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for MSLN
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    cell adhesion GO:0007155 NAS
    pancreas development GO:0031016 IEA
Subcellular Localization
    extracellular space GO:0005615 IEA
    membrane GO:0016020 NAS
    plasma membrane GO:0005886 IEA
    anchored component of membrane GO:0031225 IEA
    cell surface GO:0009986 IEA
    Golgi apparatus GO:0005794 IEA
 Experiment description of studies that identified MSLN in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MSLN
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MSLN is involved
No pathways found





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