Gene description for GXYLT1
Gene name glucoside xylosyltransferase 1
Gene symbol GXYLT1
Other names/aliases GLT8D3
Species Homo sapiens
 Database cross references - GXYLT1
ExoCarta ExoCarta_283464
Entrez Gene 283464
HGNC 27482
MIM 613321
UniProt Q4G148  
 GXYLT1 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for GXYLT1
Molecular Function
    UDP-xylosyltransferase activity GO:0035252 IDA
Biological Process
    small molecule metabolic process GO:0044281 TAS
    glycosaminoglycan metabolic process GO:0030203 TAS
    carbohydrate metabolic process GO:0005975 TAS
    chondroitin sulfate metabolic process GO:0030204 TAS
    O-glycan processing GO:0016266 IDA
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified GXYLT1 in exosomes
1
Experiment ID 226
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD9|FLOT1
EV Membrane markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
✘ EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for GXYLT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GXYLT1 is involved
PathwayEvidenceSource
A tetrasaccharide linker sequence is required for GAG synthesis TAS Reactome





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