Gene description for LRP6
Gene name	low density lipoprotein receptor-related protein 6
Gene symbol	LRP6
Other names/aliases	ADCAD2
Species	Homo sapiens
Database cross references - LRP6
ExoCarta	ExoCarta_4040
Entrez Gene	4040
HGNC	6698
MIM	603507
UniProt	O75581
LRP6 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for LRP6

Molecular Function     protein homodimerization activity GO:0042803 IPI     frizzled binding GO:0005109 IPI     toxin transporter activity GO:0019534 IMP     Wnt-protein binding GO:0017147 IPI     receptor binding GO:0005102 IPI     coreceptor activity involved in Wnt signaling pathway GO:0071936 IDA     kinase inhibitor activity GO:0019210 IMP     identical protein binding GO:0042802 IPI     low-density lipoprotein receptor activity GO:0005041 IDA     Wnt-activated receptor activity GO:0042813 IBA     protein binding GO:0005515 IPI     apolipoprotein binding GO:0034185 IBA Biological Process     embryonic hindlimb morphogenesis GO:0035116 IEA     cerebral cortex cell migration GO:0021795 IEA     heart looping GO:0001947 IEA     convergent extension GO:0060026 IBA     dopaminergic neuron differentiation GO:0071542 IEA     external genitalia morphogenesis GO:0035261 IBA     positive regulation of apoptotic process GO:0043065 IEA     canonical Wnt signaling pathway GO:0060070 IMP     canonical Wnt signaling pathway involved in neural crest cell differentiation GO:0044335 IC     neural tube closure GO:0001843 IBA     embryonic forelimb morphogenesis GO:0035115 IEA     thalamus development GO:0021794 IBA     negative regulation of protein serine/threonine kinase activity GO:0071901 IDA     skeletal system morphogenesis GO:0048705 IEA     face morphogenesis GO:0060325 IBA     cerebral cortex development GO:0021987 IBA     negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000149 IEA     post-anal tail morphogenesis GO:0036342 IEA     forebrain radial glial cell differentiation GO:0021861 IEA     mammary placode formation GO:0060596 IEA     positive regulation of mesenchymal cell proliferation GO:0002053 IEA     Wnt signaling pathway involved in forebrain neuroblast division GO:0021874 IEA     embryonic camera-type eye morphogenesis GO:0048596 IEA     embryonic pattern specification GO:0009880 IBA     primitive streak formation GO:0090009 IBA     negative regulation of protein kinase activity GO:0006469 IMP     Wnt signaling pathway GO:0016055 IMP     receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport GO:0090118 IBA     Wnt signaling pathway involved in dorsal/ventral axis specification GO:0044332 IDA     negative regulation of planar cell polarity pathway involved in neural tube closure GO:2000168 IEA     negative regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000166 IEA     canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development GO:0061310 IEA     axis elongation involved in somitogenesis GO:0090245 IBA     negative regulation of fat cell differentiation GO:0045599 IEA     positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IDA     trachea cartilage morphogenesis GO:0060535 IBA     positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification GO:2000055 IDA     regulation of cell development GO:0060284 IEA     negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:2000162 IEA     neural crest cell differentiation GO:0014033 IDA     negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000164 IEA     bone remodeling GO:0046849 IEA     positive regulation of bone resorption GO:0045780 IEA     positive regulation of cytosolic calcium ion concentration GO:0007204 IEA     positive regulation of cell cycle GO:0045787 IMP     response to peptide hormone GO:0043434 IEA     palate development GO:0060021 IBA     canonical Wnt signaling pathway involved in regulation of cell proliferation GO:0044340 IC     positive regulation of ossification GO:0045778 IEA     odontogenesis of dentin-containing tooth GO:0042475 IBA     positive regulation of transcription, DNA-templated GO:0045893 IMP     cerebellum morphogenesis GO:0021587 IBA     negative regulation of epithelial cell proliferation GO:0050680 IEA     midbrain development GO:0030901 IBA     neural crest formation GO:0014029 IDA     Wnt signaling pathway involved in somitogenesis GO:0090244 IBA     pericardium morphogenesis GO:0003344 IBA     negative regulation of canonical Wnt signaling pathway GO:0090090 TAS     single organismal cell-cell adhesion GO:0016337 IEA     negative regulation of smooth muscle cell apoptotic process GO:0034392 IMP     midbrain-hindbrain boundary development GO:0030917 IBA     toxin transport GO:1901998 IMP     cell migration involved in gastrulation GO:0042074 IEA     canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation GO:0061324 IEA     branching involved in mammary gland duct morphogenesis GO:0060444 IEA     formation of radial glial scaffolds GO:0021943 IEA     synaptic transmission GO:0007268 IBA     negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:2000151 IEA     negative regulation of protein phosphorylation GO:0001933 IMP     response to folic acid GO:0051593 IEA     cellular response to cholesterol GO:0071397 IMP     embryonic retina morphogenesis in camera-type eye GO:0060059 IBA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     embryonic digit morphogenesis GO:0042733 IEA     positive regulation of canonical Wnt signaling pathway GO:0090263 TAS Subcellular Localization     extracellular region GO:0005576 TAS     receptor complex GO:0043235 IBA     cytosol GO:0005829 IEA     neuronal cell body GO:0043025 IBA     plasma membrane GO:0005886 TAS     cell surface GO:0009986 IDA     caveola GO:0005901 IDA     early endosome membrane GO:0031901 TAS     synapse GO:0045202 IBA     integral component of membrane GO:0016021 IEA     early endosome GO:0005769 IDA     cytoplasmic vesicle GO:0031410 IDA     Golgi apparatus GO:0005794 IDA     endoplasmic reticulum GO:0005783 IEA