Gene description for CSNK1A1L
Gene name casein kinase 1, alpha 1-like
Gene symbol CSNK1A1L
Other names/aliases CK1
Species Homo sapiens
 Database cross references - CSNK1A1L
ExoCarta ExoCarta_122011
Vesiclepedia VP_122011
Entrez Gene 122011
HGNC 20289
UniProt Q8N752  
 CSNK1A1L identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CSNK1A1L
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IBA
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    ATP binding GO:0005524 IEA
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    signal transduction GO:0007165 IBA
    Wnt signaling pathway GO:0016055 IEA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified CSNK1A1L in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CSNK1A1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Cbx1  
Affinity Capture-MS Mus musculus
2 ATP12A 479
Affinity Capture-MS Homo sapiens
3 ARRB2 409
Affinity Capture-MS Homo sapiens
4 FAM170A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 TNFRSF1B  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
6 FKBPL  
Affinity Capture-MS Homo sapiens
7 CSNK1A1L 122011
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
8 KIF14 9928
Affinity Capture-MS Homo sapiens
9 ANLN 54443
Affinity Capture-MS Homo sapiens
10 BTBD9  
Affinity Capture-MS Homo sapiens
11 ECT2 1894
Affinity Capture-MS Homo sapiens
12 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
13 CHMP4C 92421
Affinity Capture-MS Homo sapiens
14 RPA2 6118
Affinity Capture-MS Homo sapiens
15 NFATC1 4772
Affinity Capture-MS Homo sapiens
16 RPA1 6117
Affinity Capture-MS Homo sapiens
17 TNFRSF1A 7132
Biochemical Activity Homo sapiens
18 CUL3 8452
Affinity Capture-MS Homo sapiens
19 KIF20A 10112
Affinity Capture-MS Homo sapiens
20 PPP1R9B 84687
Affinity Capture-MS Homo sapiens
21 JAM2  
Two-hybrid Homo sapiens
22 PPP1R9A  
Affinity Capture-MS Homo sapiens
23 FAM83H 286077
Affinity Capture-MS Homo sapiens
24 MDM4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 HMMR  
Affinity Capture-MS Homo sapiens
26 BACH1 571
Affinity Capture-MS Homo sapiens
27 CAPZB 832
Affinity Capture-MS Homo sapiens
28 CEBPE  
Two-hybrid Homo sapiens
29 CHMP4B 128866
Affinity Capture-MS Homo sapiens
30 RPA3 6119
Affinity Capture-MS Homo sapiens
31 LRP6 4040
Affinity Capture-MS Homo sapiens
32 LRP5 4041
Affinity Capture-MS Homo sapiens
33 KIF23 9493
Affinity Capture-MS Homo sapiens
34 GAPVD1 26130
Affinity Capture-MS Homo sapiens
35 FAM83B  
Affinity Capture-MS Homo sapiens
36 FAM83D 81610
Affinity Capture-MS Homo sapiens
37 ANKRD49  
Affinity Capture-MS Homo sapiens
38 FBXW7  
Affinity Capture-MS Homo sapiens
39 ARHGEF12 23365
Affinity Capture-MS Homo sapiens
40 FAM83G  
Affinity Capture-MS Homo sapiens
41 PTCH1  
Affinity Capture-MS Homo sapiens
42 ZDBF2  
Affinity Capture-MS Homo sapiens
43 PLEKHG3 26030
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CSNK1A1L is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here