Gene description for BACH1
Gene name BTB and CNC homology 1, basic leucine zipper transcription factor 1
Gene symbol BACH1
Other names/aliases BACH-1
BTBD24
Species Homo sapiens
 Database cross references - BACH1
ExoCarta ExoCarta_571
Entrez Gene 571
HGNC 935
MIM 602751
UniProt O14867  
 BACH1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for BACH1
Molecular Function
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001206 IEA
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001205 IEA
    RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 IEA
    heme binding GO:0020037 NAS
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 IMP
    sequence-specific DNA binding transcription factor activity GO:0003700 ISS
Biological Process
    DNA repair GO:0006281 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP
    regulation of transcription involved in G2/M transition of mitotic cell cycle GO:0000117 IMP
    regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083 IMP
    regulation of transcription, DNA-templated GO:0006355 ISS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 IDA
Subcellular Localization
    cytosol GO:0005829 IDA
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified BACH1 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for BACH1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BRCA1 672
Invivo Homo sapiens
Invitro Homo sapiens
2 BACH1 571
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which BACH1 is involved
No pathways found





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