Gene description for FBXL12
Gene name F-box and leucine-rich repeat protein 12
Gene symbol FBXL12
Other names/aliases Fbl12
Species Homo sapiens
 Database cross references - FBXL12
ExoCarta ExoCarta_54850
Vesiclepedia VP_54850
Entrez Gene 54850
HGNC 13611
MIM 609079
UniProt Q9NXK8  
 FBXL12 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for FBXL12
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    protein ubiquitination GO:0016567 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified FBXL12 in exosomes
1
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FBXL12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 A2M 2
Two-hybrid Homo sapiens
2 GSTP1 2950
Affinity Capture-MS Homo sapiens
3 ARSA 410
Affinity Capture-MS Homo sapiens
4 CUL1 8454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 CA6 765
Affinity Capture-MS Homo sapiens
6 ALDH3A2 224
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
7 ANXA2 302
Affinity Capture-MS Homo sapiens
8 PSEN1 5663
Two-hybrid Homo sapiens
9 NUBP2 10101
Affinity Capture-MS Homo sapiens
10 SLA  
Affinity Capture-MS Homo sapiens
11 DOCK8 81704
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
12 LAMP3  
Affinity Capture-MS Homo sapiens
13 EGLN3  
Affinity Capture-MS Homo sapiens
14 PSME3 10197
Affinity Capture-MS Homo sapiens
15 RAMP3  
Affinity Capture-MS Homo sapiens
16 BSG 682
Affinity Capture-MS Homo sapiens
17 NPTN 27020
Affinity Capture-MS Homo sapiens
18 CDC37 11140
Two-hybrid Homo sapiens
19 JUN 3725
Affinity Capture-Western Homo sapiens
20 SKP1 6500
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
21 RBX1 9978
Affinity Capture-Western Homo sapiens
22 APOE 348
Two-hybrid Homo sapiens
23 RNF32  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
24 CTDP1 9150
Affinity Capture-MS Homo sapiens
25 FBF1  
Two-hybrid Homo sapiens
26 HGH1 51236
Affinity Capture-MS Homo sapiens
27 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
28 TTC27 55622
Affinity Capture-MS Homo sapiens
29 SLURP1  
Affinity Capture-MS Homo sapiens
30 DDX58 23586
Affinity Capture-RNA Homo sapiens
31 RCN1 5954
Affinity Capture-MS Homo sapiens
32 PSEN2 5664
Two-hybrid Homo sapiens
33 BACH1 571
Affinity Capture-MS Homo sapiens
34 PRAME  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
35 RNH1 6050
Affinity Capture-MS Homo sapiens
36 GEMIN4 50628
Two-hybrid Homo sapiens
37 GPR45  
Affinity Capture-MS Homo sapiens
38 COPS6 10980
Affinity Capture-MS Homo sapiens
39 CBWD3  
Affinity Capture-MS Homo sapiens
40 FAM174A 345757
Affinity Capture-MS Homo sapiens
41 ALDH3B1 221
Affinity Capture-Western Homo sapiens
42 ALDH3A1 218
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
43 THTPA  
Affinity Capture-MS Homo sapiens
44 C9orf72  
Affinity Capture-MS Homo sapiens
45 UBE2D3 7323
Reconstituted Complex Homo sapiens
46 STYX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
47 FXYD3 5349
Two-hybrid Homo sapiens
48 CAPN1 823
Affinity Capture-MS Homo sapiens
49 MAST1  
Two-hybrid Homo sapiens
50 ASTN2  
Affinity Capture-MS Homo sapiens
51 LNX1  
Two-hybrid Homo sapiens
52 CDKN1C  
Affinity Capture-Western Homo sapiens
53 ECSIT 51295
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
54 CAPN2 824
Affinity Capture-MS Homo sapiens
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