Gene description for PSEN1
Gene name presenilin 1
Gene symbol PSEN1
Other names/aliases AD3
FAD
PS-1
PS1
S182
Species Homo sapiens
 Database cross references - PSEN1
ExoCarta ExoCarta_5663
Vesiclepedia VP_5663
Entrez Gene 5663
HGNC 9508
MIM 104311
UniProt P49768  
 PSEN1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
 Gene ontology annotations for PSEN1
Molecular Function
    endopeptidase activity GO:0004175 IDA
    endopeptidase activity GO:0004175 IGI
    endopeptidase activity GO:0004175 IMP
    aspartic-type endopeptidase activity GO:0004190 NAS
    calcium channel activity GO:0005262 IMP
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 IPI
    PDZ domain binding GO:0030165 IPI
    aspartic endopeptidase activity, intramembrane cleaving GO:0042500 IBA
    aspartic endopeptidase activity, intramembrane cleaving GO:0042500 IDA
    aspartic endopeptidase activity, intramembrane cleaving GO:0042500 IMP
    cadherin binding GO:0045296 IEA
    ATPase binding GO:0051117 IPI
    growth factor receptor binding GO:0070851 IPI
Biological Process
    autophagosome assembly GO:0000045 IEA
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    blood vessel development GO:0001568 IEA
    cell fate specification GO:0001708 IEA
    somitogenesis GO:0001756 IEA
    neuron migration GO:0001764 IEA
    positive regulation of receptor recycling GO:0001921 IEA
    heart looping GO:0001947 IEA
    positive regulation of L-glutamate import across plasma membrane GO:0002038 IEA
    hematopoietic progenitor cell differentiation GO:0002244 IEA
    astrocyte activation involved in immune response GO:0002265 IGI
    T cell activation involved in immune response GO:0002286 IEA
    neural retina development GO:0003407 IEA
    protein glycosylation GO:0006486 IEA
    membrane protein ectodomain proteolysis GO:0006509 IBA
    membrane protein ectodomain proteolysis GO:0006509 IDA
    mitochondrial transport GO:0006839 IEA
    DNA damage response GO:0006974 IDA
    response to oxidative stress GO:0006979 IEA
    Notch signaling pathway GO:0007219 IBA
    Notch receptor processing GO:0007220 IDA
    Notch receptor processing GO:0007220 TAS
    learning or memory GO:0007611 IGI
    memory GO:0007613 IGI
    post-embryonic development GO:0009791 IEA
    regulation of gene expression GO:0010468 IGI
    positive regulation of gene expression GO:0010628 IGI
    negative regulation of gene expression GO:0010629 IGI
    regulation of neuron projection development GO:0010975 IMP
    protein transport GO:0015031 IEA
    choline transport GO:0015871 IEA
    synaptic vesicle targeting GO:0016080 IEA
    protein processing GO:0016485 IBA
    protein processing GO:0016485 IDA
    protein processing GO:0016485 IGI
    protein processing GO:0016485 IMP
    cerebellum development GO:0021549 IEA
    cerebral cortex cell migration GO:0021795 IEA
    Cajal-Retzius cell differentiation GO:0021870 IEA
    dorsal/ventral neural tube patterning GO:0021904 IEA
    embryonic limb morphogenesis GO:0030326 IEA
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IEA
    endoplasmic reticulum calcium ion homeostasis GO:0032469 IDA
    endoplasmic reticulum calcium ion homeostasis GO:0032469 IGI
    endoplasmic reticulum calcium ion homeostasis GO:0032469 IMP
    positive regulation of tumor necrosis factor production GO:0032760 IGI
    amyloid-beta formation GO:0034205 IBA
    amyloid-beta formation GO:0034205 IDA
    amyloid-beta formation GO:0034205 IGI
    amyloid-beta formation GO:0034205 IMP
    intracellular signal transduction GO:0035556 IEA
    locomotion GO:0040011 IEA
    positive regulation of protein import into nucleus GO:0042307 IMP
    regulation of phosphorylation GO:0042325 IDA
    amyloid precursor protein metabolic process GO:0042982 IDA
    amyloid precursor protein catabolic process GO:0042987 IDA
    amyloid precursor protein catabolic process GO:0042987 IGI
    amyloid precursor protein catabolic process GO:0042987 IMP
    amyloid precursor protein catabolic process GO:0042987 TAS
    myeloid dendritic cell differentiation GO:0043011 IEA
    positive regulation of apoptotic process GO:0043065 IEA
    negative regulation of apoptotic process GO:0043066 IDA
    negative regulation of apoptotic process GO:0043066 IMP
    negative regulation of neuron apoptotic process GO:0043524 IEA
    skin morphogenesis GO:0043589 IEA
    positive regulation of glycolytic process GO:0045821 IGI
    positive regulation of DNA-templated transcription GO:0045893 IMP
    astrocyte activation GO:0048143 IGI
    regulation of synaptic plasticity GO:0048167 IEA
    thymus development GO:0048538 IEA
    neuron development GO:0048666 IEA
    skeletal system morphogenesis GO:0048705 IEA
    brain morphogenesis GO:0048854 IEA
    epithelial cell proliferation GO:0050673 IEA
    negative regulation of axonogenesis GO:0050771 IEA
    synapse organization GO:0050808 IGI
    positive regulation of coagulation GO:0050820 IEA
    T cell receptor signaling pathway GO:0050852 IEA
    sequestering of calcium ion GO:0051208 IEA
    neuron apoptotic process GO:0051402 IEA
    smooth endoplasmic reticulum calcium ion homeostasis GO:0051563 IEA
    regulation of synaptic transmission, glutamatergic GO:0051966 IEA
    calcium ion homeostasis GO:0055074 IBA
    regulation of resting membrane potential GO:0060075 IEA
    regulation of canonical Wnt signaling pathway GO:0060828 ISS
    positive regulation of dendritic spine development GO:0060999 IMP
    neuron cellular homeostasis GO:0070050 IEA
    calcium ion transmembrane transport GO:0070588 IEA
    apoptotic signaling pathway GO:0097190 IEA
    cell-cell adhesion GO:0098609 IMP
    regulation of synaptic vesicle cycle GO:0098693 IEA
    L-glutamate import across plasma membrane GO:0098712 IEA
    regulation of postsynapse organization GO:0099175 IEA
    protein catabolic process at postsynapse GO:0140249 IEA
    cellular response to amyloid-beta GO:1904646 IGI
    negative regulation of core promoter binding GO:1904797 IMP
    positive regulation of amyloid fibril formation GO:1905908 IGI
    neuron projection maintenance GO:1990535 IGI
    negative regulation of ubiquitin-dependent protein catabolic process GO:2000059 IEA
    negative regulation of apoptotic signaling pathway GO:2001234 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    kinetochore GO:0000776 IDA
    nucleus GO:0005634 IMP
    nuclear outer membrane GO:0005640 IDA
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IEA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    smooth endoplasmic reticulum GO:0005790 IDA
    smooth endoplasmic reticulum GO:0005790 IDA
    rough endoplasmic reticulum GO:0005791 IDA
    Golgi apparatus GO:0005794 IDA
    centrosome GO:0005813 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    cell cortex GO:0005938 IEA
    synaptic vesicle GO:0008021 IEA
    cell surface GO:0009986 IEA
    membrane GO:0016020 IDA
    membrane GO:0016020 TAS
    aggresome GO:0016235 IDA
    cell junction GO:0030054 IDA
    dendrite GO:0030425 IDA
    growth cone GO:0030426 IDA
    neuromuscular junction GO:0031594 IEA
    early endosome membrane GO:0031901 IEA
    nuclear membrane GO:0031965 IDA
    protein-containing complex GO:0032991 IMP
    ciliary rootlet GO:0035253 IEA
    azurophil granule membrane GO:0035577 TAS
    sarcolemma GO:0042383 IEA
    presynaptic membrane GO:0042734 IEA
    neuron projection GO:0043005 IDA
    neuronal cell body GO:0043025 IEA
    dendritic shaft GO:0043198 IEA
    membrane raft GO:0045121 IDA
    gamma-secretase complex GO:0070765 IBA
    gamma-secretase complex GO:0070765 IDA
    gamma-secretase complex GO:0070765 IGI
    postsynapse GO:0098794 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified PSEN1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for PSEN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAMP3  
Affinity Capture-MS Homo sapiens
2 OXCT1 5019
Two-hybrid Homo sapiens
3 ERN1  
Affinity Capture-Western Homo sapiens
4 GPR45  
Affinity Capture-MS Homo sapiens
5 SYNGR1 9145
Affinity Capture-MS Homo sapiens
6 CDH8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 GFAP 2670
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
8 DTNA  
Co-fractionation Homo sapiens
9 APOE 348
Two-hybrid Homo sapiens
10 UBC 7316
Co-localization Homo sapiens
11 KLRB1  
Affinity Capture-MS Homo sapiens
12 CFL1 1072
Two-hybrid Homo sapiens
13 APP 351
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
14 TOMM22 56993
Co-fractionation Homo sapiens
15 TGFBR1 7046
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
16 CHCHD4  
Co-fractionation Homo sapiens
17 RHEB 6009
Two-hybrid Homo sapiens
18 ECSIT 51295
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
19 TAX1BP3 30851
Affinity Capture-MS Homo sapiens
20 CDH2 1000
Affinity Capture-Western Homo sapiens
21 FBXW7  
Affinity Capture-Western Homo sapiens
22 TDP2 51567
Two-hybrid Homo sapiens
23 ETFA 2108
Two-hybrid Homo sapiens
24 PRDX2 7001
Two-hybrid Homo sapiens
25 UBQLN1 29979
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
26 Ncstn 59287
Affinity Capture-MS Mus musculus
27 PSEN2 5664
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
28 PGD 5226
Co-fractionation Homo sapiens
29 IVD 3712
Co-fractionation Homo sapiens
30 GSAP  
Affinity Capture-Western Homo sapiens
31 NCSTN 23385
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
32 Ctnnb1 12387
Affinity Capture-Western Mus musculus
33 GSK3B 2932
Biochemical Activity Homo sapiens
34 LAMTOR1 55004
Proximity Label-MS Homo sapiens
35 UNK  
Affinity Capture-RNA Homo sapiens
36 EPB41L3 23136
Two-hybrid Homo sapiens
37 ENSA 2029
Two-hybrid Homo sapiens
38 PTPRN2  
Affinity Capture-MS Homo sapiens
39 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
40 RNF32  
Two-hybrid Homo sapiens
41 ST3GAL1 6482
Affinity Capture-MS Homo sapiens
42 CDK5 1020
Two-hybrid Homo sapiens
43 CLSTN1 22883
Affinity Capture-Western Homo sapiens
44 P2RY8  
Affinity Capture-MS Homo sapiens
45 MAPT  
Co-fractionation Homo sapiens
46 EFHD1  
Two-hybrid Homo sapiens
47 CDH1 999
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
48 TUBA1B 10376
Two-hybrid Homo sapiens
49 APH1B 83464
Affinity Capture-Western Homo sapiens
50 FLNB 2317
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
51 CIB1 10519
Two-hybrid Homo sapiens
52 BCL2L1 598
Two-hybrid Homo sapiens
53 DHX9 1660
Co-fractionation Homo sapiens
54 ICAM5 7087
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
55 FGF13  
Two-hybrid Homo sapiens
56 CDH12  
Affinity Capture-MS Homo sapiens
57 HERPUD1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
58 RMDN3 55177
Two-hybrid Homo sapiens
59 ST13 6767
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
60 ACTN1 87
Two-hybrid Homo sapiens
61 VAMP3 9341
Affinity Capture-MS Homo sapiens
62 TMEM30A 55754
Co-fractionation Homo sapiens
63 PSEN1 5663
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
64 TCF7L2  
Affinity Capture-Western Homo sapiens
65 PSENEN  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
66 DUOXA2  
Affinity Capture-MS Homo sapiens
67 DNAJC2 27000
Affinity Capture-MS Homo sapiens
68 NOS3  
Two-hybrid Homo sapiens
69 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
70 GCDH 2639
Two-hybrid Homo sapiens
71 MGARP  
Affinity Capture-MS Homo sapiens
72 TRAF6 7189
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
73 FBXL12 54850
Two-hybrid Homo sapiens
74 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
75 CYP2C18  
Two-hybrid Homo sapiens
76 PDCD4 27250
Two-hybrid Homo sapiens
77 SERP2  
Affinity Capture-MS Homo sapiens
78 UMPS 7372
Two-hybrid Homo sapiens
79 YME1L1 10730
Two-hybrid Homo sapiens
80 PKP4 8502
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
81 AP1M2 10053
Two-hybrid Homo sapiens
82 VIPR1  
Affinity Capture-MS Homo sapiens
83 CTNNA1 1495
Affinity Capture-Western Homo sapiens
84 RAB3A 5864
Two-hybrid Homo sapiens
85 STAMBPL1  
Two-hybrid Homo sapiens
86 PSMB1 5689
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
87 ADGRE5 976
Affinity Capture-MS Homo sapiens
88 DSP 1832
Co-fractionation Homo sapiens
89 KCNIP3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
90 CYP2C8  
Two-hybrid Homo sapiens
91 RAD23A 5886
Two-hybrid Homo sapiens
92 IRAK2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
93 TSPAN5 10098
Affinity Capture-MS Homo sapiens
94 NAAA  
Affinity Capture-MS Homo sapiens
95 ALDH9A1 223
Co-fractionation Homo sapiens
96 HMGB1 3146
Two-hybrid Homo sapiens
97 MFSD4  
Affinity Capture-MS Homo sapiens
98 TXNRD2 10587
Co-fractionation Homo sapiens
99 RYR2 6262
Reconstituted Complex Homo sapiens
100 CDC37 11140
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
101 ERLIN2 11160
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
102 PRAM1  
Two-hybrid Homo sapiens
103 MCFD2 90411
Co-fractionation Homo sapiens
104 ITSN2 50618
Two-hybrid Homo sapiens
105 NDUFS8 4728
Co-fractionation Homo sapiens
106 GAPDH 2597
Two-hybrid Homo sapiens
107 BCL2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
108 PSMA5 5686
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
109 SPPL2B 56928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 POMK  
Affinity Capture-MS Homo sapiens
111 KANK2 25959
Two-hybrid Homo sapiens
112 KCNIP4 80333
Two-hybrid Homo sapiens
113 KRAS 3845
Proximity Label-MS Homo sapiens
114 APH1A 51107
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
115 SLC1A1 6505
Affinity Capture-MS Homo sapiens
116 PTGER4  
Affinity Capture-Western Homo sapiens
117 SCN1A  
Two-hybrid Homo sapiens
118 NOTCH1 4851
Affinity Capture-Western Homo sapiens
119 CTNND1 1500
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
120 S1PR4  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PSEN1 is involved
PathwayEvidenceSource
Activated NOTCH1 Transmits Signal to the Nucleus IEA Reactome
Axon guidance TAS Reactome
Cell death signalling via NRAGE, NRIF and NADE TAS Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants TAS Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants TAS Reactome
Death Receptor Signaling TAS Reactome
Degradation of the extracellular matrix IEA Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
EPH-ephrin mediated repulsion of cells TAS Reactome
EPH-Ephrin signaling TAS Reactome
Extracellular matrix organization IEA Reactome
Immune System TAS Reactome
Innate Immune System TAS Reactome
Nervous system development TAS Reactome
Neutrophil degranulation TAS Reactome
Noncanonical activation of NOTCH3 TAS Reactome
NOTCH2 Activation and Transmission of Signal to the Nucleus IEA Reactome
NOTCH3 Activation and Transmission of Signal to the Nucleus TAS Reactome
NOTCH4 Activation and Transmission of Signal to the Nucleus IEA Reactome
NRIF signals cell death from the nucleus TAS Reactome
Nuclear signaling by ERBB4 TAS Reactome
p75 NTR receptor-mediated signalling TAS Reactome
Regulated proteolysis of p75NTR TAS Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
Signaling by ERBB4 TAS Reactome
Signaling by NOTCH IEA Reactome
Signaling by NOTCH TAS Reactome
Signaling by NOTCH1 IEA Reactome
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer TAS Reactome
Signaling by NOTCH1 in Cancer TAS Reactome
Signaling by NOTCH1 PEST Domain Mutants in Cancer TAS Reactome
Signaling by NOTCH2 IEA Reactome
Signaling by NOTCH3 TAS Reactome
Signaling by NOTCH4 IEA Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by TGFB family members TAS Reactome
Signaling by TGFBR3 TAS Reactome
TGFBR3 PTM regulation TAS Reactome