Gene description for TXNRD2
Gene name thioredoxin reductase 2
Gene symbol TXNRD2
Other names/aliases SELZ
TR
TR-BETA
TR3
TRXR2
Species Homo sapiens
 Database cross references - TXNRD2
ExoCarta ExoCarta_10587
Vesiclepedia VP_10587
Entrez Gene 10587
HGNC 18155
MIM 606448
UniProt Q9NNW7  
 TXNRD2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TXNRD2
Molecular Function
    thioredoxin-disulfide reductase (NADPH) activity GO:0004791 IBA
    thioredoxin-disulfide reductase (NADPH) activity GO:0004791 ISS
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 ISS
    protein-containing complex binding GO:0044877 IEA
    flavin adenine dinucleotide binding GO:0050660 IEA
Biological Process
    response to oxygen radical GO:0000305 TAS
    response to xenobiotic stimulus GO:0009410 IEA
    response to selenium ion GO:0010269 IEA
    cell redox homeostasis GO:0045454 IBA
    cell redox homeostasis GO:0045454 IMP
    response to hyperoxia GO:0055093 IEA
    cellular oxidant detoxification GO:0098869 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 TAS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    axon GO:0030424 IEA
    dendrite GO:0030425 IEA
    neuronal cell body GO:0043025 IEA
 Experiment description of studies that identified TXNRD2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TXNRD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IVD 3712
Co-fractionation Homo sapiens
2 CS 1431
Co-fractionation Homo sapiens
3 NCOA6  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
4 UQCRFS1 7386
Affinity Capture-MS Homo sapiens
5 GLUD1 2746
Co-fractionation Homo sapiens
6 TF 7018
Co-fractionation Homo sapiens
7 PPP1R3C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PSEN1 5663
Co-fractionation Homo sapiens
9 IDH1 3417
Co-fractionation Homo sapiens
10 PSMC3 5702
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
11 NDUFA13 51079
Affinity Capture-MS Homo sapiens
12 TADA3  
Two-hybrid Homo sapiens
13 EZR 7430
Co-fractionation Homo sapiens
14 CYP2S1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 NCOA2 10499
Two-hybrid Homo sapiens
16 AGA 175
Co-fractionation Homo sapiens
17 TXNRD1 7296
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 BPNT1 10380
Affinity Capture-MS Homo sapiens
19 TXNDC12 51060
Co-fractionation Homo sapiens
20 PI4K2A 55361
Affinity Capture-MS Homo sapiens
21 ECHS1 1892
Co-fractionation Homo sapiens
22 OAT 4942
Co-fractionation Homo sapiens
23 OXCT1 5019
Co-fractionation Homo sapiens
24 TRAP1 10131
Co-fractionation Homo sapiens
25 MCFD2 90411
Co-fractionation Homo sapiens
26 CHCHD4  
Co-fractionation Homo sapiens
27 AKR1B1 231
Co-fractionation Homo sapiens
28 DNAJC5 80331
Co-fractionation Homo sapiens
29 NCOR1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
30 RDX 5962
Co-fractionation Homo sapiens
31 GTF2H1 2965
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
32 ACOX1 51
Co-fractionation Homo sapiens
33 TYK2 7297
Co-fractionation Homo sapiens
34 PMPCA 23203
Co-fractionation Homo sapiens
35 FLRT1  
Affinity Capture-MS Homo sapiens
36 GOT1 2805
Co-fractionation Homo sapiens
37 AADAT  
Co-fractionation Homo sapiens
38 ENO2 2026
Co-fractionation Homo sapiens
39 KRAS 3845
Synthetic Lethality Homo sapiens
40 FOXR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 PNPLA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 RECQL 5965
Co-fractionation Homo sapiens
43 CCBL2 56267
Co-fractionation Homo sapiens
44 PGD 5226
Co-fractionation Homo sapiens
45 GSR 2936
Co-fractionation Homo sapiens
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