Gene description for KCNIP4
Gene name Kv channel interacting protein 4
Gene symbol KCNIP4
Other names/aliases CALP
Species Homo sapiens
 Database cross references - KCNIP4
ExoCarta ExoCarta_80333
Entrez Gene 80333
HGNC 30083
MIM 608182
UniProt Q6PIL6  
 KCNIP4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for KCNIP4
Molecular Function
    potassium channel activity GO:0005267 IEA
    calcium ion binding GO:0005509 IDA
    potassium channel regulator activity GO:0015459 ISS
    voltage-gated ion channel activity GO:0005244 IEA
Biological Process
    regulation of potassium ion transmembrane transport GO:1901379 ISS
    potassium ion transmembrane transport GO:0071805 IEA
    protein localization to plasma membrane GO:0072659 ISS
Subcellular Localization
    neuronal cell body GO:0043025 IEA
    dendrite GO:0030425 IEA
    endoplasmic reticulum GO:0005783 IEA
    cytosol GO:0005829 ISS
    plasma membrane GO:0005886 ISS
    cytoplasm GO:0005737 IDA
    voltage-gated potassium channel complex GO:0008076 ISS
 Experiment description of studies that identified KCNIP4 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for KCNIP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSEN2  
Invivo Homo sapiens
Two-hybrid Homo sapiens
2 KCNIP2  
Affinity Capture-MS Homo sapiens
3 KCND2  
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which KCNIP4 is involved
No pathways found

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