Gene description for SYNGR1
Gene name synaptogyrin 1
Gene symbol SYNGR1
Other names/aliases -
Species Homo sapiens
 Database cross references - SYNGR1
ExoCarta ExoCarta_9145
Vesiclepedia VP_9145
Entrez Gene 9145
HGNC 11498
MIM 603925
UniProt O43759  
 SYNGR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Melanoma cells 25950383    
 Gene ontology annotations for SYNGR1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    protein targeting GO:0006605 IEA
    regulated exocytosis GO:0045055 ISS
    regulation of long-term neuronal synaptic plasticity GO:0048169 ISS
    regulation of short-term neuronal synaptic plasticity GO:0048172 ISS
    synaptic vesicle membrane organization GO:0048499 ISS
    cellular response to leukemia inhibitory factor GO:1990830 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 NAS
    synaptic vesicle membrane GO:0030672 IBA
    neuromuscular junction GO:0031594 IBA
    azurophil granule membrane GO:0035577 TAS
    melanosome GO:0042470 IEA
    Schaffer collateral - CA1 synapse GO:0098685 IEA
 Experiment description of studies that identified SYNGR1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 258
MISEV standards
EM
Biophysical techniques
TSG101|FLOT1|CD81
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SYNGR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NDUFAF1  
Affinity Capture-MS Homo sapiens
2 DUSP22  
Affinity Capture-MS Homo sapiens
3 UBE2S  
Affinity Capture-MS Homo sapiens
4 CMTM6 54918
Affinity Capture-MS Homo sapiens
5 EMC7 56851
Affinity Capture-MS Homo sapiens
6 ANO6 196527
Affinity Capture-MS Homo sapiens
7 GPRC5C 55890
Affinity Capture-MS Homo sapiens
8 DNAJC11 55735
Affinity Capture-MS Homo sapiens
9 TMBIM6 7009
Affinity Capture-MS Homo sapiens
10 GPAA1 8733
Affinity Capture-MS Homo sapiens
11 TMEM87A 25963
Affinity Capture-MS Homo sapiens
12 DHCR24 1718
Affinity Capture-MS Homo sapiens
13 ATP1A3 478
Affinity Capture-MS Homo sapiens
14 RER1 11079
Affinity Capture-MS Homo sapiens
15 POTEI 653269
Affinity Capture-MS Homo sapiens
16 MSMO1 6307
Affinity Capture-MS Homo sapiens
17 ATP2B1 490
Affinity Capture-MS Homo sapiens
18 HMOX2 3163
Affinity Capture-MS Homo sapiens
19 APOB 338
Affinity Capture-MS Homo sapiens
20 RGP1 9827
Affinity Capture-MS Homo sapiens
21 PCNXL3 399909
Affinity Capture-MS Homo sapiens
22 ERGIC3 51614
Affinity Capture-MS Homo sapiens
23 SURF4 6836
Affinity Capture-MS Homo sapiens
24 SPNS1 83985
Affinity Capture-MS Homo sapiens
25 RABL3 285282
Affinity Capture-MS Homo sapiens
26 UNC93B1 81622
Affinity Capture-MS Homo sapiens
27 PIGU 128869
Affinity Capture-MS Homo sapiens
28 RIC1 57589
Affinity Capture-MS Homo sapiens
29 SCAMP3 10067
Affinity Capture-MS Homo sapiens
30 GHITM 27069
Affinity Capture-MS Homo sapiens
31 ORC4  
Affinity Capture-MS Homo sapiens
32 PTRH2 51651
Affinity Capture-MS Homo sapiens
33 ERGIC2 51290
Affinity Capture-MS Homo sapiens
34 MAOB  
Affinity Capture-MS Homo sapiens
35 ALG3 10195
Affinity Capture-MS Homo sapiens
36 TBRG4 9238
Affinity Capture-MS Homo sapiens
37 SLC20A1 6574
Affinity Capture-MS Homo sapiens
38 TNPO2 30000
Affinity Capture-MS Homo sapiens
39 C16orf58 64755
Affinity Capture-MS Homo sapiens
40 SYNJ2BP 55333
Affinity Capture-MS Homo sapiens
41 SLC43A3 29015
Affinity Capture-MS Homo sapiens
42 TMCO1 54499
Affinity Capture-MS Homo sapiens
43 SCAMP2 10066
Affinity Capture-MS Homo sapiens
44 CMTM5  
Affinity Capture-MS Homo sapiens
45 ATP2B2 491
Affinity Capture-MS Homo sapiens
46 SPAG9 9043
Affinity Capture-MS Homo sapiens
47 SLC38A10 124565
Affinity Capture-MS Homo sapiens
48 YES1 7525
Affinity Capture-MS Homo sapiens
49 ACAD9 28976
Affinity Capture-MS Homo sapiens
50 CREB3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
51 MPDU1 9526
Affinity Capture-MS Homo sapiens
52 CLPTM1L 81037
Affinity Capture-MS Homo sapiens
53 CERS6  
Affinity Capture-MS Homo sapiens
54 SYNGR2 9144
Affinity Capture-MS Homo sapiens
55 B3GAT3 26229
Affinity Capture-MS Homo sapiens
56 ADGRE5 976
Affinity Capture-MS Homo sapiens
57 WFS1 7466
Affinity Capture-MS Homo sapiens
58 PSEN1 5663
Affinity Capture-MS Homo sapiens
59 CRACR2A  
Affinity Capture-MS Homo sapiens
60 SLC7A1 6541
Affinity Capture-MS Homo sapiens
61 FATE1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
62 LEMD3  
Affinity Capture-MS Homo sapiens
63 ZDHHC13 54503
Affinity Capture-MS Homo sapiens
64 MTMR4  
Affinity Capture-MS Homo sapiens
65 GOLGA5 9950
Affinity Capture-MS Homo sapiens
66 ATP13A1 57130
Affinity Capture-MS Homo sapiens
67 ECSIT 51295
Affinity Capture-MS Homo sapiens
68 YIPF3 25844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 PIGO  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SYNGR1 is involved
PathwayEvidenceSource
Immune System TAS Reactome
Innate Immune System TAS Reactome
Neutrophil degranulation TAS Reactome





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