Gene description for RER1
Gene name retention in endoplasmic reticulum sorting receptor 1
Gene symbol RER1
Other names/aliases -
Species Homo sapiens
 Database cross references - RER1
ExoCarta ExoCarta_11079
Vesiclepedia VP_11079
Entrez Gene 11079
HGNC 30309
UniProt O15258  
 RER1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Thymus 23844026    
 Gene ontology annotations for RER1
Molecular Function
    protein binding GO:0005515 IPI
    acetylcholine receptor binding GO:0033130 IEA
Biological Process
    protein retention in ER lumen GO:0006621 IBA
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 IBA
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 IDA
    skeletal muscle acetylcholine-gated channel clustering GO:0071340 IEA
    positive regulation of protein localization to plasma membrane GO:1903078 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IBA
    Golgi membrane GO:0000139 IDA
    endoplasmic reticulum GO:0005783 IEA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IEA
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 IEA
    cell surface GO:0009986 IEA
 Experiment description of studies that identified RER1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RER1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STRA6 64220
Affinity Capture-MS Homo sapiens
2 SEC22B 9554
Affinity Capture-MS Homo sapiens
3 GJD3  
Proximity Label-MS Homo sapiens
4 HBB 3043
Affinity Capture-MS Homo sapiens
5 C5AR1  
Affinity Capture-MS Homo sapiens
6 TOR1A 1861
Affinity Capture-MS Homo sapiens
7 UBL4A 8266
Affinity Capture-MS Homo sapiens
8 RAB1A 5861
Co-fractionation Homo sapiens
9 LAMP3  
Proximity Label-MS Homo sapiens
10 SYNGR1 9145
Affinity Capture-MS Homo sapiens
11 SLC39A4 55630
Affinity Capture-MS Homo sapiens
12 SRPRB 58477
Affinity Capture-MS Homo sapiens
13 TMEM184A  
Affinity Capture-MS Homo sapiens
14 ETFB 2109
Affinity Capture-MS Homo sapiens
15 DPEP1 1800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TMEM72  
Affinity Capture-MS Homo sapiens
17 SYVN1 84447
Affinity Capture-Western Homo sapiens
18 FFAR1  
Affinity Capture-MS Homo sapiens
19 ATP5L 10632
Co-fractionation Homo sapiens
20 B3GAT1  
Proximity Label-MS Homo sapiens
21 SYCE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 IARS2 55699
Affinity Capture-MS Homo sapiens
23 COPB2 9276
Affinity Capture-MS Homo sapiens
24 NIPAL1  
Affinity Capture-MS Homo sapiens
25 SIGMAR1 10280
Affinity Capture-MS Homo sapiens
26 ATP5O 539
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
27 NDUFA3  
Affinity Capture-MS Homo sapiens
28 CCDC47 57003
Affinity Capture-MS Homo sapiens
29 ATG16L1 55054
Affinity Capture-MS Homo sapiens
30 ATP5H 10476
Co-fractionation Homo sapiens
31 RABAC1 10567
Affinity Capture-MS Homo sapiens
32 ATP13A3 79572
Affinity Capture-MS Homo sapiens
33 STX12 23673
Co-fractionation Homo sapiens
34 ATP1A3 478
Affinity Capture-MS Homo sapiens
35 WIPF1 7456
Two-hybrid Homo sapiens
36 NUP155 9631
Proximity Label-MS Homo sapiens
37 UNK  
Affinity Capture-RNA Homo sapiens
38 MRPS30 10884
Affinity Capture-MS Homo sapiens
39 KCNK1  
Affinity Capture-MS Homo sapiens
40 ATP5A1 498
Co-fractionation Homo sapiens
41 SCFD1 23256
Affinity Capture-MS Homo sapiens
42 IFITM3 10410
Affinity Capture-MS Homo sapiens
43 P2RY8  
Affinity Capture-MS Homo sapiens
44 HSP90B1 7184
Affinity Capture-MS Homo sapiens
45 SCAND1  
Two-hybrid Homo sapiens
46 SH3GL3  
Two-hybrid Homo sapiens
47 PGRMC2 10424
Affinity Capture-MS Homo sapiens
48 C12orf49  
Negative Genetic Homo sapiens
49 CYB5A 1528
Affinity Capture-MS Homo sapiens
50 SREBF2 6721
Positive Genetic Homo sapiens
51 S1PR1 1901
Affinity Capture-MS Homo sapiens
52 GORASP2 26003
Affinity Capture-MS Homo sapiens
53 GPR182  
Affinity Capture-MS Homo sapiens
54 APOB 338
Affinity Capture-MS Homo sapiens
55 RAB2A 5862
Affinity Capture-MS Homo sapiens
56 PON2 5445
Affinity Capture-MS Homo sapiens
57 UPK1A 11045
Affinity Capture-MS Homo sapiens
58 TMEM33 55161
Affinity Capture-MS Homo sapiens
59 SEC62 7095
Affinity Capture-MS Homo sapiens
60 VDAC2 7417
Co-fractionation Homo sapiens
61 TMEM185A  
Affinity Capture-MS Homo sapiens
62 REEP5 7905
Proximity Label-MS Homo sapiens
63 HAP1  
Two-hybrid Homo sapiens
64 BCAP31 10134
Co-fractionation Homo sapiens
65 C4orf32  
Affinity Capture-MS Homo sapiens
66 SLC30A2  
Affinity Capture-MS Homo sapiens
67 TMED9 54732
Affinity Capture-MS Homo sapiens
68 TMX3 54495
Affinity Capture-MS Homo sapiens
69 CANX 821
Affinity Capture-MS Homo sapiens
70 DNAJB12 54788
Affinity Capture-MS Homo sapiens
71 ATP5I 521
Co-fractionation Homo sapiens
72 LETM1 3954
Affinity Capture-MS Homo sapiens
73 CAV2 858
Affinity Capture-MS Homo sapiens
74 LAMP1 3916
Proximity Label-MS Homo sapiens
75 SLC35F2 54733
Affinity Capture-MS Homo sapiens
76 ACADM 34
Affinity Capture-MS Homo sapiens
77 CD274 29126
Affinity Capture-MS Homo sapiens
78 ERGIC3 51614
Affinity Capture-MS Homo sapiens
79 P2RY2 5029
Affinity Capture-MS Homo sapiens
80 ENDOD1 23052
Affinity Capture-MS Homo sapiens
81 EGFR 1956
Affinity Capture-MS Homo sapiens
82 TST 7263
Affinity Capture-MS Homo sapiens
83 AQP3  
Affinity Capture-MS Homo sapiens
84 YIPF5 81555
Affinity Capture-MS Homo sapiens
85 ERP44 23071
Affinity Capture-MS Homo sapiens
86 FASN 2194
Negative Genetic Homo sapiens
87 TSPAN8 7103
Affinity Capture-MS Homo sapiens
88 CHRNA9  
Affinity Capture-MS Homo sapiens
89 CNR2  
Affinity Capture-MS Homo sapiens
90 RPA3 6119
Proximity Label-MS Homo sapiens
91 ATP2A1 487
Proximity Label-MS Homo sapiens
92 ACKR2  
Affinity Capture-MS Homo sapiens
93 PMP22  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
94 RNF2  
Affinity Capture-MS Homo sapiens
95 CRELD1 78987
Affinity Capture-MS Homo sapiens
96 LDLR 3949
Positive Genetic Homo sapiens
97 GPR84  
Affinity Capture-MS Homo sapiens
98 OSBPL8 114882
Affinity Capture-MS Homo sapiens
99 PPIF 10105
Affinity Capture-MS Homo sapiens
100 LMAN2 10960
Affinity Capture-MS Homo sapiens
101 YIF1B 90522
Affinity Capture-MS Homo sapiens
102 IMMT 10989
Two-hybrid Homo sapiens
103 SLC2A12 154091
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 MTHFD2 10797
Affinity Capture-MS Homo sapiens
105 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
106 TSPAN5 10098
Affinity Capture-MS Homo sapiens
107 ALDH3A2 224
Affinity Capture-MS Homo sapiens
108 SERINC2 347735
Affinity Capture-MS Homo sapiens
109 PGRMC1 10857
Affinity Capture-MS Homo sapiens
110 GOSR1 9527
Affinity Capture-MS Homo sapiens
111 MFSD4  
Affinity Capture-MS Homo sapiens
112 SYT16  
Two-hybrid Homo sapiens
113 IER3IP1 51124
Affinity Capture-MS Homo sapiens
114 ALDH1B1 219
Affinity Capture-MS Homo sapiens
115 HBA2 3040
Affinity Capture-MS Homo sapiens
116 COX5A 9377
Affinity Capture-MS Homo sapiens
117 LMAN2L 81562
Affinity Capture-MS Homo sapiens
118 CDC25C  
Affinity Capture-MS Homo sapiens
119 ERGIC1 57222
Proximity Label-MS Homo sapiens
120 OAT 4942
Affinity Capture-MS Homo sapiens
121 TRAP1 10131
Affinity Capture-MS Homo sapiens
122 GFM1 85476
Affinity Capture-MS Homo sapiens
123 SLC11A2 4891
Affinity Capture-MS Homo sapiens
124 HLA-DPA1  
Affinity Capture-MS Homo sapiens
125 SPPL2B 56928
Affinity Capture-MS Homo sapiens
126 POMK  
Affinity Capture-MS Homo sapiens
127 SERBP1 26135
Affinity Capture-MS Homo sapiens
128 TMED7 51014
Affinity Capture-MS Homo sapiens
129 VIPR1  
Affinity Capture-MS Homo sapiens
130 RAB5C 5878
Proximity Label-MS Homo sapiens
131 HTR1B  
Affinity Capture-MS Homo sapiens
132 CCR6  
Affinity Capture-MS Homo sapiens
133 VDAC3 7419
Affinity Capture-MS Homo sapiens
134 CCR1  
Affinity Capture-MS Homo sapiens
135 FPR2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RER1 is involved
No pathways found





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