Gene description for SLC11A2
Gene name solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
Gene symbol SLC11A2
Other names/aliases DCT1
DMT1
NRAMP2
Species Homo sapiens
 Database cross references - SLC11A2
ExoCarta ExoCarta_4891
Entrez Gene 4891
HGNC 10908
MIM 600523
UniProt P49281  
 SLC11A2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SLC11A2
Molecular Function
    zinc ion binding GO:0008270 IEA
    copper ion binding GO:0005507 IEA
    transition metal ion transmembrane transporter activity GO:0046915 IDA
    cadmium ion binding GO:0046870 IDA
    inorganic cation transmembrane transporter activity GO:0022890 IGI
    ferrous iron transmembrane transporter activity GO:0015093 IDA
    zinc ion transmembrane transporter activity GO:0005385 IDA
    nickel cation transmembrane transporter activity GO:0015099 IEA
    cobalt ion transmembrane transporter activity GO:0015087 IEA
    hydrogen ion transmembrane transporter activity GO:0015078 IEA
    vanadium ion transmembrane transporter activity GO:0015100 IDA
    chromium ion transmembrane transporter activity GO:0070835 IDA
    solute:proton symporter activity GO:0015295 IDA
    lead ion transmembrane transporter activity GO:0015094 IDA
    manganese ion binding GO:0030145 IEA
    calcium ion transmembrane transporter activity GO:0015085 IDA
    manganese ion transmembrane transporter activity GO:0005384 IDA
    cobalt ion binding GO:0050897 IEA
    cadmium ion transmembrane transporter activity GO:0015086 IDA
    nickel cation binding GO:0016151 IEA
    iron ion binding GO:0005506 IEA
    ferrous iron uptake transmembrane transporter activity GO:0015639 IMP
    copper ion transmembrane transporter activity GO:0005375 IDA
    protein binding GO:0005515 IPI
Biological Process
    ferrous iron transport GO:0015684 IDA
    manganese ion transport GO:0006828 IDA
    ferrous iron transmembrane transport GO:1903874 IMP
    zinc II ion transmembrane transport GO:0071577 IDA
    cellular response to tumor necrosis factor GO:0071356 IEA
    cobalt ion transport GO:0006824 IEA
    heme biosynthetic process GO:0006783 IEA
    response to manganese ion GO:0010042 IEA
    cellular response to oxidative stress GO:0034599 IDA
    nickel cation transport GO:0015675 IDA
    learning or memory GO:0007611 IEA
    cellular iron ion homeostasis GO:0006879 TAS
    response to iron ion GO:0010039 IEP
    hydrogen ion transmembrane transport GO:1902600 IEA
    copper ion transport GO:0006825 IDA
    copper ion import into cell GO:1902861 IEA
    detection of oxygen GO:0003032 IEP
    lead ion transport GO:0015692 IDA
    response to cadmium ion GO:0046686 IEA
    dendrite morphogenesis GO:0048813 IEA
    cellular response to hypoxia GO:0071456 IEA
    erythrocyte development GO:0048821 IEA
    vanadium ion transport GO:0015676 IDA
    activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IDA
    response to lead ion GO:0010288 IEA
    nickel cation transmembrane transport GO:0035444 IEA
    multicellular organismal iron ion homeostasis GO:0060586 IMP
    ferrous iron import GO:0070627 IEA
    cellular copper ion homeostasis GO:0006878 IEA
    transmembrane transport GO:0055085 TAS
    cellular response to iron ion GO:0071281 IEA
    manganese ion transmembrane transport GO:0071421 IEA
    response to hypoxia GO:0001666 IEP
    copper ion transmembrane transport GO:0035434 IEA
    cadmium ion transmembrane transport GO:0070574 IDA
    cation transmembrane transport GO:0098655 IGI
Subcellular Localization
    paraferritin complex GO:0070826 IDA
    cell surface GO:0009986 IEA
    brush border GO:0005903 IEA
    membrane GO:0016020 IDA
    vacuole GO:0005773 IMP
    late endosome GO:0005770 IDA
    apical part of cell GO:0045177 IDA
    mitochondrial outer membrane GO:0005741 IEA
    perinuclear region of cytoplasm GO:0048471 IDA
    apical plasma membrane GO:0016324 IDA
    recycling endosome GO:0055037 IDA
    nucleus GO:0005634 IDA
    early endosome GO:0005769 IDA
    late endosome membrane GO:0031902 IDA
    cytoplasmic vesicle GO:0031410 IDA
    integral component of plasma membrane GO:0005887 IMP
    plasma membrane GO:0005886 TAS
    lysosomal membrane GO:0005765 IDA
    lysosome GO:0005764 IDA
    basal part of cell GO:0045178 IDA
    retromer complex GO:0030904 IDA
    trans-Golgi network GO:0005802 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified SLC11A2 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SLC11A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC11A2 is involved
PathwayEvidenceSource
Iron uptake and transport TAS Reactome
Metal ion SLC transporters TAS Reactome





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