Gene description for SIGMAR1
Gene name sigma non-opioid intracellular receptor 1
Gene symbol SIGMAR1
Other names/aliases ALS16
OPRS1
SIG-1R
SR-BP
SR-BP1
SRBP
hSigmaR1
sigma1R
Species Homo sapiens
 Database cross references - SIGMAR1
ExoCarta ExoCarta_10280
Vesiclepedia VP_10280
Entrez Gene 10280
HGNC 8157
MIM 601978
UniProt Q99720  
 SIGMAR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SIGMAR1
Molecular Function
    G protein-coupled opioid receptor activity GO:0004985 IEA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
Biological Process
    lipid transport GO:0006869 IEA
    nervous system development GO:0007399 IEA
    G protein-coupled opioid receptor signaling pathway GO:0038003 IEA
    regulation of neuron apoptotic process GO:0043523 IMP
    protein homotrimerization GO:0070207 IPI
    regulation of postsynapse assembly GO:0150052 IEA
Subcellular Localization
    nuclear envelope GO:0005635 IDA
    nuclear inner membrane GO:0005637 IEA
    nuclear outer membrane GO:0005640 IEA
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    lipid droplet GO:0005811 IEA
    cytosol GO:0005829 TAS
    postsynaptic density GO:0014069 IDA
    membrane GO:0016020 IDA
    growth cone GO:0030426 IEA
    cytoplasmic vesicle GO:0031410 IEA
    anchoring junction GO:0070161 IEA
    postsynaptic density membrane GO:0098839 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified SIGMAR1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SIGMAR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSD17B11 51170
Affinity Capture-MS Homo sapiens
2 SLC31A2  
Affinity Capture-MS Homo sapiens
3 ANK2 287
Affinity Capture-Western Homo sapiens
4 DHCR24 1718
Affinity Capture-MS Homo sapiens
5 ARL6IP5 10550
Affinity Capture-MS Homo sapiens
6 TMEM184A  
Affinity Capture-MS Homo sapiens
7 SLC2A1 6513
Affinity Capture-MS Homo sapiens
8 GPR114  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TMEM72  
Affinity Capture-MS Homo sapiens
10 C5AR1  
Affinity Capture-MS Homo sapiens
11 KDELR1 10945
Affinity Capture-MS Homo sapiens
12 ATP5L 10632
Affinity Capture-MS Homo sapiens
13 KIAA1429 25962
Affinity Capture-MS Homo sapiens
14 PIGN 23556
Affinity Capture-MS Homo sapiens
15 ALG3 10195
Affinity Capture-MS Homo sapiens
16 APLNR  
Affinity Capture-MS Homo sapiens
17 SLC6A5  
Affinity Capture-MS Homo sapiens
18 YIPF3 25844
Affinity Capture-MS Homo sapiens
19 GPRC5B 51704
Affinity Capture-MS Homo sapiens
20 RER1 11079
Affinity Capture-MS Homo sapiens
21 RTN1 6252
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SRI 6717
Reconstituted Complex Homo sapiens
23 FZD7 8324
Affinity Capture-MS Homo sapiens
24 TMEM87A 25963
Affinity Capture-MS Homo sapiens
25 AGPAT2  
Affinity Capture-MS Homo sapiens
26 KCNK1  
Affinity Capture-MS Homo sapiens
27 VEZT 55591
Affinity Capture-MS Homo sapiens
28 NPC1 4864
Affinity Capture-MS Homo sapiens
29 PLSCR1 5359
Affinity Capture-MS Homo sapiens
30 STOM 2040
Affinity Capture-MS Homo sapiens
31 P2RY8  
Affinity Capture-MS Homo sapiens
32 TUBGCP4 27229
Affinity Capture-MS Homo sapiens
33 GPR52  
Affinity Capture-MS Homo sapiens
34 TSPAN2 10100
Affinity Capture-MS Homo sapiens
35 SLC43A3 29015
Affinity Capture-MS Homo sapiens
36 GPR182  
Affinity Capture-MS Homo sapiens
37 TMEM63A 9725
Affinity Capture-MS Homo sapiens
38 CD63 967
Affinity Capture-MS Homo sapiens
39 GPR173  
Affinity Capture-MS Homo sapiens
40 TMPRSS13  
Affinity Capture-MS Homo sapiens
41 CDS2 8760
Affinity Capture-MS Homo sapiens
42 ACAT1 38
Co-fractionation Homo sapiens
43 CLN3 1201
Affinity Capture-MS Homo sapiens
44 AK2 204
Co-fractionation Homo sapiens
45 CXCR4 7852
Affinity Capture-MS Homo sapiens
46 SLC35F2 54733
Affinity Capture-MS Homo sapiens
47 CMKLR1 1240
Affinity Capture-MS Homo sapiens
48 LPAR1 1902
Affinity Capture-MS Homo sapiens
49 NXF1 10482
Affinity Capture-RNA Homo sapiens
50 FAM134C 162427
Affinity Capture-MS Homo sapiens
51 CNR2  
Affinity Capture-MS Homo sapiens
52 RPA3 6119
Proximity Label-MS Homo sapiens
53 GPR45  
Affinity Capture-MS Homo sapiens
54 ACKR2  
Affinity Capture-MS Homo sapiens
55 ASPH 444
Affinity Capture-MS Homo sapiens
56 SLC12A6 9990
Affinity Capture-MS Homo sapiens
57 RNF185  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 GPR84  
Affinity Capture-MS Homo sapiens
59 SAYSD1  
Affinity Capture-MS Homo sapiens
60 SLC4A2 6522
Affinity Capture-MS Homo sapiens
61 GPR17 2840
Affinity Capture-MS Homo sapiens
62 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
63 ADORA2B  
Affinity Capture-MS Homo sapiens
64 TACR1  
Affinity Capture-MS Homo sapiens
65 GOLT1A  
Affinity Capture-MS Homo sapiens
66 TMEM208  
Affinity Capture-MS Homo sapiens
67 SERINC2 347735
Affinity Capture-MS Homo sapiens
68 RTN3 10313
Affinity Capture-MS Homo sapiens
69 MFSD4  
Affinity Capture-MS Homo sapiens
70 TSPAN15 23555
Affinity Capture-MS Homo sapiens
71 ITPR3 3710
Affinity Capture-Western Homo sapiens
72 AGPAT3 56894
Affinity Capture-MS Homo sapiens
73 DDX58 23586
Affinity Capture-RNA Homo sapiens
74 RABL3 285282
Affinity Capture-MS Homo sapiens
75 PDZD11 51248
Two-hybrid Homo sapiens
76 MOV10 4343
Affinity Capture-RNA Homo sapiens
77 CGRRF1  
Affinity Capture-MS Homo sapiens
78 SPPL2B 56928
Affinity Capture-MS Homo sapiens
79 ZNRF4  
Affinity Capture-MS Homo sapiens
80 VIPR1  
Affinity Capture-MS Homo sapiens
81 HTR1B  
Affinity Capture-MS Homo sapiens
82 CCR1  
Affinity Capture-MS Homo sapiens
83 BRI3BP 140707
Affinity Capture-MS Homo sapiens
84 FPR2  
Affinity Capture-MS Homo sapiens
85 KIAA1644  
Affinity Capture-MS Homo sapiens
86 S1PR4  
Affinity Capture-MS Homo sapiens
87 RNF139  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SIGMAR1 is involved
PathwayEvidenceSource
Disease TAS Reactome
Infectious disease TAS Reactome
Potential therapeutics for SARS TAS Reactome
SARS-CoV Infections TAS Reactome
Viral Infection Pathways TAS Reactome





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