Gene description for TNPO2
Gene name
transportin 2
Gene symbol
TNPO2
Other names/aliases
IPO3 KPNB2B TRN2
Species
Homo sapiens
Database cross references - TNPO2
ExoCarta
ExoCarta_30000
Entrez Gene
30000
HGNC
19998
MIM
603002
UniProt
O14787
TNPO2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells
25944692
Thymus
23844026
Gene ontology annotations for TNPO2
Experiment description of studies that identified TNPO2 in exosomes
1
Experiment ID
224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25944692
Organism
Homo sapiens
Experiment description
Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors
Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name
Oncotarget
Publication year
2015
Sample
Neuroblastoma cells
Sample name
SH-SY5Y
Isolation/purification methods
Differential centrifugation Ultracentrifugation OptiPrep density gradient
Flotation density
1.10 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry Western blotting
2
Experiment ID
217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23844026
Organism
Homo sapiens
Experiment description
Characterization of human thymic exosomes.
Authors
Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name
PLoS One
Publication year
2013
Sample
Thymus
Sample name
Normal-Thymus
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for TNPO2
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
ACF
Reconstituted Complex
Homo sapiens
2
NXF1
10482
Invivo
Homo sapiens
3
PTP4A3
Affinity Capture-MS
Homo sapiens
View the network
image/svg+xml
Pathways in which TNPO2 is involved
No pathways found