Gene description for TNPO2
Gene name transportin 2
Gene symbol TNPO2
Other names/aliases IPO3
KPNB2B
TRN2
Species Homo sapiens
 Database cross references - TNPO2
ExoCarta ExoCarta_30000
Entrez Gene 30000
HGNC 19998
MIM 603002
UniProt O14787  
 TNPO2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Thymus 23844026    
 Gene ontology annotations for TNPO2
Molecular Function
    protein binding GO:0005515 IPI
    nuclear localization sequence binding GO:0008139 TAS
    Ran GTPase binding GO:0008536 IEA
Biological Process
    intracellular protein transport GO:0006886 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified TNPO2 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TNPO2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACF  
Reconstituted Complex Homo sapiens
2 NXF1 10482
Invivo Homo sapiens
3 PTP4A3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TNPO2 is involved
No pathways found





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