Gene description for VAMP5
Gene name vesicle-associated membrane protein 5
Gene symbol VAMP5
Other names/aliases -
Species Homo sapiens
 Database cross references - VAMP5
ExoCarta ExoCarta_10791
Entrez Gene 10791
HGNC 12646
MIM 607029
UniProt O95183  
 VAMP5 identified in exosomes derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
 Gene ontology annotations for VAMP5
Molecular Function
    SNAP receptor activity GO:0005484 IBA
    protein binding GO:0005515 IPI
    SNARE binding GO:0000149 IBA
Biological Process
    muscle organ development GO:0007517 TAS
    cell differentiation GO:0030154 IEA
    exocytosis GO:0006887 IBA
    Golgi to plasma membrane protein transport GO:0043001 IEA
    skeletal muscle tissue development GO:0007519 IEA
    vesicle fusion GO:0006906 IBA
Subcellular Localization
    integral component of plasma membrane GO:0005887 IEA
    cell surface GO:0009986 IDA
    SNARE complex GO:0031201 IBA
    extracellular exosome GO:0070062 IDA
    late endosome GO:0005770 ISS
    integral component of organelle membrane GO:0031301 ISS
    intercalated disc GO:0014704 ISS
    plasma membrane GO:0005886 TAS
    synaptic vesicle GO:0008021 IBA
    trans-Golgi network GO:0005802 IEA
    cytoplasmic vesicle membrane GO:0030659 ISS
    perinuclear region of cytoplasm GO:0048471 ISS
 Experiment description of studies that identified VAMP5 in exosomes
1
Experiment ID 79
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD81|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD81|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD81|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
 Protein-protein interactions for VAMP5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which VAMP5 is involved
No pathways found





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