Gene description for TMEM106C
Gene name transmembrane protein 106C
Gene symbol TMEM106C
Other names/aliases -
Species Homo sapiens
 Database cross references - TMEM106C
ExoCarta ExoCarta_79022
Vesiclepedia VP_79022
Entrez Gene 79022
HGNC 28775
UniProt Q9BVX2  
 TMEM106C identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TMEM106C
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
 Experiment description of studies that identified TMEM106C in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TMEM106C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TMEM35  
Two-hybrid Homo sapiens
2 UPK2 7379
Two-hybrid Homo sapiens
3 TOR3A 64222
Affinity Capture-MS Homo sapiens
4 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
5 MYADM 91663
Two-hybrid Homo sapiens
6 PLN  
Two-hybrid Homo sapiens
7 HLA-DPB1 3115
Affinity Capture-MS Homo sapiens
8 BTNL2  
Affinity Capture-MS Homo sapiens
9 TMEM106A  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
10 C14orf180  
Two-hybrid Homo sapiens
11 TMEM106B 54664
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
12 PLP1 5354
Two-hybrid Homo sapiens
13 CD3E 916
Affinity Capture-MS Homo sapiens
14 GP9 2815
Affinity Capture-MS Homo sapiens
15 ZFPL1 7542
Two-hybrid Homo sapiens
16 YIPF6 286451
Two-hybrid Homo sapiens
17 NRSN1  
Two-hybrid Homo sapiens
18 DUOXA2  
Affinity Capture-MS Homo sapiens
19 SMAGP  
Two-hybrid Homo sapiens
20 ADAM33 80332
Two-hybrid Homo sapiens
21 ASIC4  
Affinity Capture-MS Homo sapiens
22 CD1B 910
Affinity Capture-MS Homo sapiens
23 PGA4  
Two-hybrid Homo sapiens
24 ATP1B4  
Affinity Capture-MS Homo sapiens
25 ITM2C 81618
Affinity Capture-MS Homo sapiens
26 AIG1  
Two-hybrid Homo sapiens
27 TSPAN33 340348
Two-hybrid Homo sapiens
28 PTPLA  
Two-hybrid Homo sapiens
29 GOSR2 9570
Two-hybrid Homo sapiens
30 IGFBP5 3488
Two-hybrid Homo sapiens
31 FAXDC2  
Two-hybrid Homo sapiens
32 KRTAP10-3  
Two-hybrid Homo sapiens
33 SLURP1  
Affinity Capture-MS Homo sapiens
34 JAGN1 84522
Two-hybrid Homo sapiens
35 MAL  
Two-hybrid Homo sapiens
36 CMTM7  
Two-hybrid Homo sapiens
37 SFTPC  
Two-hybrid Homo sapiens
38 BNIP3 664
Two-hybrid Homo sapiens
39 SERP2  
Two-hybrid Homo sapiens
40 CHRNB2  
Affinity Capture-MS Homo sapiens
41 HLA-DPA1  
Affinity Capture-MS Homo sapiens
42 RPRM  
Two-hybrid Homo sapiens
43 RAB7A 7879
Proximity Label-MS Homo sapiens
44 SEC22A  
Two-hybrid Homo sapiens
45 NCEH1 57552
Affinity Capture-MS Homo sapiens
46 VAMP5 10791
Two-hybrid Homo sapiens
47 CXCL9  
Two-hybrid Homo sapiens
48 RPN1 6184
Proximity Label-MS Homo sapiens
49 CTXN3  
Two-hybrid Homo sapiens
50 PTTG1IP 754
Two-hybrid Homo sapiens
51 HLA-DQB1 3119
Affinity Capture-MS Homo sapiens
52 TMEM11 8834
Two-hybrid Homo sapiens
53 PPAPDC2  
Two-hybrid Homo sapiens
54 SSR1 6745
Proximity Label-MS Homo sapiens
55 HLA-DRB1 3123
Affinity Capture-MS Homo sapiens
56 NKG7  
Two-hybrid Homo sapiens
57 CLDN19  
Two-hybrid Homo sapiens
58 KRT31 3881
Two-hybrid Homo sapiens
59 EDDM3B  
Two-hybrid Homo sapiens
60 TMEM97 27346
Two-hybrid Homo sapiens
61 ZACN  
Affinity Capture-MS Homo sapiens
62 HLA-C 3107
Affinity Capture-MS Homo sapiens
63 TMEM218  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM106C is involved
No pathways found





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