Gene description for CD3E
Gene name CD3e molecule, epsilon (CD3-TCR complex)
Gene symbol CD3E
Other names/aliases IMD18
T3E
TCRE
Species Homo sapiens
 Database cross references - CD3E
ExoCarta ExoCarta_916
Vesiclepedia VP_916
Entrez Gene 916
HGNC 1674
MIM 186830
UniProt P07766  
 CD3E identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CD3E
Molecular Function
    transmembrane signaling receptor activity GO:0004888 IBA
    transmembrane signaling receptor activity GO:0004888 IC
    transmembrane signaling receptor activity GO:0004888 IDA
    protein binding GO:0005515 IPI
    SH3 domain binding GO:0017124 IPI
    protein kinase binding GO:0019901 NAS
    signaling receptor complex adaptor activity GO:0030159 NAS
    T cell receptor binding GO:0042608 NAS
    identical protein binding GO:0042802 IDA
Biological Process
    positive regulation of cell-matrix adhesion GO:0001954 ISS
    adaptive immune response GO:0002250 NAS
    positive regulation of T cell anergy GO:0002669 IEA
    T cell anergy GO:0002870 IEA
    cell surface receptor signaling pathway GO:0007166 IBA
    cell surface receptor signaling pathway GO:0007166 IC
    cell surface receptor signaling pathway GO:0007166 NAS
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 TAS
    signal complex assembly GO:0007172 TAS
    G protein-coupled receptor signaling pathway GO:0007186 TAS
    smoothened signaling pathway GO:0007224 IEA
    positive regulation of gene expression GO:0010628 IMP
    negative regulation of gene expression GO:0010629 IMP
    dendrite development GO:0016358 IEA
    calcium-mediated signaling GO:0019722 IEA
    cerebellum development GO:0021549 IEA
    T cell costimulation GO:0031295 IEA
    positive regulation of type II interferon production GO:0032729 IEA
    positive regulation of interleukin-2 production GO:0032743 IEA
    positive regulation of interleukin-4 production GO:0032753 IEA
    positive regulation of cell-cell adhesion mediated by integrin GO:0033634 ISS
    CD4-positive, alpha-beta T cell proliferation GO:0035739 IEA
    positive regulation of T cell proliferation GO:0042102 IMP
    T cell activation GO:0042110 NAS
    regulation of apoptotic process GO:0042981 NAS
    positive thymic T cell selection GO:0045059 IBA
    negative thymic T cell selection GO:0045060 IEA
    negative regulation of smoothened signaling pathway GO:0045879 IEA
    gamma-delta T cell activation GO:0046629 NAS
    alpha-beta T cell activation GO:0046631 NAS
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA
    positive regulation of calcium-mediated signaling GO:0050850 IEA
    T cell receptor signaling pathway GO:0050852 IDA
    T cell receptor signaling pathway GO:0050852 NAS
    protein-containing complex assembly GO:0065003 NAS
    apoptotic signaling pathway GO:0097190 IEA
    positive regulation of CD4-positive, alpha-beta T cell proliferation GO:2000563 IEA
Subcellular Localization
    immunological synapse GO:0001772 IEA
    endoplasmic reticulum GO:0005783 IDA
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 NAS
    plasma membrane GO:0005886 TAS
    cell-cell junction GO:0005911 IEA
    external side of plasma membrane GO:0009897 IBA
    external side of plasma membrane GO:0009897 IDA
    T cell receptor complex GO:0042101 IDA
    alpha-beta T cell receptor complex GO:0042105 IBA
    alpha-beta T cell receptor complex GO:0042105 IDA
    alpha-beta T cell receptor complex GO:0042105 IPI
    alpha-beta T cell receptor complex GO:0042105 ISS
    gamma-delta T cell receptor complex GO:0042106 NAS
    dendritic spine GO:0043197 IEA
    cell body GO:0044297 IEA
 Experiment description of studies that identified CD3E in exosomes
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CD3E
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3EAP  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 DPY19L1 23333
Affinity Capture-MS Homo sapiens
3 TMEM9 252839
Affinity Capture-MS Homo sapiens
4 CD38 952
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
5 LRFN1  
Affinity Capture-MS Homo sapiens
6 COPG2 26958
Affinity Capture-MS Homo sapiens
7 FZD6 8323
Affinity Capture-MS Homo sapiens
8 MUC15  
Two-hybrid Homo sapiens
9 LAT 27040
Affinity Capture-Western Homo sapiens
10 GPX8 493869
Affinity Capture-MS Homo sapiens
11 CRYGS 1427
Affinity Capture-MS Homo sapiens
12 NCK1 4690
Reconstituted Complex Homo sapiens
13 TMEM30A 55754
Affinity Capture-MS Homo sapiens
14 SCNN1A  
Affinity Capture-MS Homo sapiens
15 PTPN22  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
16 CSK 1445
Reconstituted Complex Homo sapiens
17 ZFPL1 7542
Two-hybrid Homo sapiens
18 TMEM106C 79022
Affinity Capture-MS Homo sapiens
19 TOP2B 7155
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
20 TGFBR1 7046
Affinity Capture-MS Homo sapiens
21 ADAM33 80332
Two-hybrid Homo sapiens
22 LCK 3932
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 GHDC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 TMEM59L  
Affinity Capture-MS Homo sapiens
25 GRAMD1A  
Affinity Capture-MS Homo sapiens
26 LNPEP 4012
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 PKMYT1  
Two-hybrid Homo sapiens
28 LRRC8A 56262
Affinity Capture-MS Homo sapiens
29 ROR2 4920
Affinity Capture-MS Homo sapiens
30 NCK2 8440
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
31 CD247 919
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
32 CD3G 917
Affinity Capture-Western Homo sapiens
33 JAK3 3718
Affinity Capture-Western Homo sapiens
34 TM2D3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 ITFG1 81533
Affinity Capture-MS Homo sapiens
36 NCL 4691
Reconstituted Complex Homo sapiens
37 HS2ST1 9653
Affinity Capture-MS Homo sapiens
38 GP1BB 2812
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 UBASH3A 53347
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
40 ITPRIPL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 ZAP70 7535
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
42 RDH11 51109
Affinity Capture-MS Homo sapiens
43 FAM134C 162427
Affinity Capture-MS Homo sapiens
44 TMEM259 91304
Affinity Capture-MS Homo sapiens
45 PIK3R2 5296
Affinity Capture-Western Homo sapiens
46 PIK3R1 5295
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
47 BNIP3 664
Two-hybrid Homo sapiens
48 SYK 6850
Reconstituted Complex Homo sapiens
49 VANGL1 81839
Affinity Capture-MS Homo sapiens
50 C10orf35  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 HLA-A 3105
Affinity Capture-MS Homo sapiens
52 BRI3BP 140707
Affinity Capture-MS Homo sapiens
53 RNF149 284996
Affinity Capture-MS Homo sapiens
54 DNAJC16  
Affinity Capture-MS Homo sapiens
55 WFS1 7466
Affinity Capture-MS Homo sapiens
56 KIAA0922  
Affinity Capture-MS Homo sapiens
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