Gene description for CD3E
Gene name CD3e molecule, epsilon (CD3-TCR complex)
Gene symbol CD3E
Other names/aliases IMD18
T3E
TCRE
Species Homo sapiens
 Database cross references - CD3E
ExoCarta ExoCarta_916
Entrez Gene 916
HGNC 1674
MIM 186830
UniProt P07766  
 CD3E identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CD3E
Molecular Function
    SH3 domain binding GO:0017124 IPI
    protein binding GO:0005515 IPI
    transmembrane signaling receptor activity GO:0004888 NAS
    receptor signaling protein activity GO:0005057 TAS
    protein kinase binding GO:0019901 NAS
    T cell receptor binding GO:0042608 NAS
    receptor signaling complex scaffold activity GO:0030159 NAS
    protein heterodimerization activity GO:0046982 IPI
Biological Process
    positive regulation of interleukin-2 biosynthetic process GO:0045086 IEA
    positive regulation of alpha-beta T cell proliferation GO:0046641 IEA
    regulation of apoptotic process GO:0042981 NAS
    protein complex assembly GO:0006461 NAS
    regulation of immune response GO:0050776 TAS
    G-protein coupled receptor signaling pathway GO:0007186 TAS
    positive regulation of T cell proliferation GO:0042102 IMP
    T cell costimulation GO:0031295 TAS
    response to nutrient GO:0007584 IEA
    positive regulation of T cell anergy GO:0002669 IEA
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 TAS
    positive regulation of interferon-gamma production GO:0032729 IEA
    positive regulation of interleukin-4 production GO:0032753 IEA
    T cell receptor signaling pathway GO:0050852 TAS
    signal complex assembly GO:0007172 TAS
    apoptotic signaling pathway GO:0097190 IEA
    intracellular signal transduction GO:0035556 TAS
    cell surface receptor signaling pathway GO:0007166 NAS
    negative regulation of smoothened signaling pathway GO:0045879 IEA
    positive regulation of calcium-mediated signaling GO:0050850 IEA
    T cell activation GO:0042110 NAS
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA
    negative thymic T cell selection GO:0045060 IEA
Subcellular Localization
    immunological synapse GO:0001772 IEA
    plasma membrane GO:0005886 TAS
    integral component of plasma membrane GO:0005887 NAS
    T cell receptor complex GO:0042101 NAS
    external side of plasma membrane GO:0009897 IDA
    cell-cell junction GO:0005911 IEA
    intracellular GO:0005622 TAS
    alpha-beta T cell receptor complex GO:0042105 IEA
 Experiment description of studies that identified CD3E in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CD3E
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3EAP  
Invivo Homo sapiens
Invitro Homo sapiens
2 NCK2 8440
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
3 CD247 919
Invivo Homo sapiens
4 TRA@  
Invivo Homo sapiens
5 PIK3R1 5295
Affinity Capture-Western Homo sapiens
6 SYK 6850
Invivo Homo sapiens
Invitro Homo sapiens
7 NCL 4691
Reconstituted Complex Homo sapiens
8 CD3D 915
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
9 TOP2B 7155
Invivo Homo sapiens
Invitro Homo sapiens
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