Gene description for CD3E
Gene name	CD3e molecule, epsilon (CD3-TCR complex)
Gene symbol	CD3E
Other names/aliases	IMD18 T3E TCRE
Species	Homo sapiens
Database cross references - CD3E
ExoCarta	ExoCarta_916
Vesiclepedia	VP_916
Entrez Gene	916
HGNC	1674
MIM	186830
UniProt	P07766
CD3E identified in sEVs derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for CD3E

Molecular Function     transmembrane signaling receptor activity GO:0004888 IBA     transmembrane signaling receptor activity GO:0004888 IC     transmembrane signaling receptor activity GO:0004888 IDA     protein binding GO:0005515 IPI     SH3 domain binding GO:0017124 IPI     protein kinase binding GO:0019901 NAS     signaling receptor complex adaptor activity GO:0030159 NAS     T cell receptor binding GO:0042608 NAS     identical protein binding GO:0042802 IDA Biological Process     positive regulation of cell-matrix adhesion GO:0001954 ISS     adaptive immune response GO:0002250 NAS     positive regulation of T cell anergy GO:0002669 IEA     T cell anergy GO:0002870 IEA     cell surface receptor signaling pathway GO:0007166 IBA     cell surface receptor signaling pathway GO:0007166 IC     cell surface receptor signaling pathway GO:0007166 NAS     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 TAS     signal complex assembly GO:0007172 TAS     G protein-coupled receptor signaling pathway GO:0007186 TAS     smoothened signaling pathway GO:0007224 IEA     positive regulation of gene expression GO:0010628 IMP     negative regulation of gene expression GO:0010629 IMP     dendrite development GO:0016358 IEA     calcium-mediated signaling GO:0019722 IEA     cerebellum development GO:0021549 IEA     T cell costimulation GO:0031295 IEA     positive regulation of type II interferon production GO:0032729 IEA     positive regulation of interleukin-2 production GO:0032743 IEA     positive regulation of interleukin-4 production GO:0032753 IEA     positive regulation of cell-cell adhesion mediated by integrin GO:0033634 ISS     CD4-positive, alpha-beta T cell proliferation GO:0035739 IEA     positive regulation of T cell proliferation GO:0042102 IMP     T cell activation GO:0042110 NAS     regulation of apoptotic process GO:0042981 NAS     positive thymic T cell selection GO:0045059 IBA     negative thymic T cell selection GO:0045060 IEA     negative regulation of smoothened signaling pathway GO:0045879 IEA     gamma-delta T cell activation GO:0046629 NAS     alpha-beta T cell activation GO:0046631 NAS     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA     positive regulation of calcium-mediated signaling GO:0050850 IEA     T cell receptor signaling pathway GO:0050852 IDA     T cell receptor signaling pathway GO:0050852 NAS     protein-containing complex assembly GO:0065003 NAS     apoptotic signaling pathway GO:0097190 IEA     positive regulation of CD4-positive, alpha-beta T cell proliferation GO:2000563 IEA Subcellular Localization     immunological synapse GO:0001772 IEA     endoplasmic reticulum GO:0005783 IDA     Golgi apparatus GO:0005794 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISS     plasma membrane GO:0005886 NAS     plasma membrane GO:0005886 TAS     cell-cell junction GO:0005911 IEA     external side of plasma membrane GO:0009897 IBA     external side of plasma membrane GO:0009897 IDA     T cell receptor complex GO:0042101 IDA     alpha-beta T cell receptor complex GO:0042105 IBA     alpha-beta T cell receptor complex GO:0042105 IDA     alpha-beta T cell receptor complex GO:0042105 IPI     alpha-beta T cell receptor complex GO:0042105 ISS     gamma-delta T cell receptor complex GO:0042106 NAS     dendritic spine GO:0043197 IEA     cell body GO:0044297 IEA