Gene description for CD3G
Gene name CD3g molecule, gamma (CD3-TCR complex)
Gene symbol CD3G
Other names/aliases CD3-GAMMA
IMD17
T3G
Species Homo sapiens
 Database cross references - CD3G
ExoCarta ExoCarta_917
Entrez Gene 917
HGNC 1675
MIM 186740
UniProt P09693  
 CD3G identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CD3G
Molecular Function
    protein heterodimerization activity GO:0046982 IPI
    T cell receptor binding GO:0042608 NAS
    transmembrane signaling receptor activity GO:0004888 IMP
    receptor signaling complex scaffold activity GO:0030159 NAS
Biological Process
    establishment or maintenance of cell polarity GO:0007163 IMP
    innate immune response GO:0045087 TAS
    T cell activation GO:0042110 NAS
    protein transport GO:0015031 IMP
    regulation of immune response GO:0050776 TAS
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    T cell receptor signaling pathway GO:0050852 TAS
    regulation of lymphocyte apoptotic process GO:0070228 IMP
    T cell costimulation GO:0031295 TAS
    protein complex assembly GO:0006461 NAS
    cell surface receptor signaling pathway GO:0007166 IMP
Subcellular Localization
    plasma membrane GO:0005886 TAS
    T cell receptor complex GO:0042101 NAS
    integral component of plasma membrane GO:0005887 NAS
    alpha-beta T cell receptor complex GO:0042105 IEA
 Experiment description of studies that identified CD3G in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CD3G
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3D 915
Invitro Homo sapiens
Invivo Homo sapiens
2 TRA@  
Invivo Homo sapiens
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