Gene description for PIK3R2
Gene name phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Gene symbol PIK3R2
Other names/aliases MPPH
MPPH1
P85B
p85
p85-BETA
Species Homo sapiens
 Database cross references - PIK3R2
ExoCarta ExoCarta_5296
Vesiclepedia VP_5296
Entrez Gene 5296
HGNC 8980
MIM 603157
UniProt O00459  
 PIK3R2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PIK3R2
Molecular Function
    1-phosphatidylinositol-3-kinase activity GO:0016303 ISS
    receptor tyrosine kinase binding GO:0030971 IPI
    protein binding GO:0005515 IPI
    protein heterodimerization activity GO:0046982 ISS
    protein phosphatase binding GO:0019903 IPI
    1-phosphatidylinositol-3-kinase regulator activity GO:0046935 IBA
Biological Process
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    cellular response to insulin stimulus GO:0032869 ISS
    phosphatidylinositol phosphorylation GO:0046854 IBA
    phosphatidylinositol 3-kinase signaling GO:0014065 IDA
    insulin receptor signaling pathway GO:0008286 TAS
    regulation of phosphatidylinositol 3-kinase activity GO:0043551 IBA
    T cell receptor signaling pathway GO:0050852 TAS
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    protein transport GO:0015031 IEA
    innate immune response GO:0045087 TAS
    blood coagulation GO:0007596 TAS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    small molecule metabolic process GO:0044281 TAS
    response to endoplasmic reticulum stress GO:0034976 ISS
    small GTPase mediated signal transduction GO:0007264 TAS
    regulation of autophagy GO:0010506 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    leukocyte migration GO:0050900 TAS
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    cellular glucose homeostasis GO:0001678 ISS
    phospholipid metabolic process GO:0006644 TAS
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 ISS
    positive regulation of transcription factor import into nucleus GO:0042993 ISS
    vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    phosphatidylinositol 3-kinase complex GO:0005942 IBA
    nucleus GO:0005634 ISS
 Experiment description of studies that identified PIK3R2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PIK3R2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ERBB2 2064
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
2 EGF 1950
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
3 CBL 867
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
4 TGFBR1 7046
Invivo Homo sapiens
5 TEC 7006
Two-hybrid Homo sapiens
6 PIK3CD 5293
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
7 KIT 3815
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
8 ERBB4 2066
Affinity Capture-MS Homo sapiens
9 FYN 2534
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
10 CRKL 1399
Invitro Homo sapiens
11 ERBB3 2065
Affinity Capture-MS Homo sapiens
12 CSF1 1435
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
13 AXL 558
Biochemical Activity Homo sapiens
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