Gene description for PIK3CB
Gene name phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Gene symbol PIK3CB
Other names/aliases P110BETA
PI3K
PI3KBETA
PIK3C1
Species Homo sapiens
 Database cross references - PIK3CB
ExoCarta ExoCarta_5291
Entrez Gene 5291
HGNC 8976
MIM 602925
UniProt P42338  
 PIK3CB identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PIK3CB
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol 3-kinase activity GO:0035004 TAS
    phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 IBA
    1-phosphatidylinositol-3-kinase activity GO:0016303 IEA
    1-phosphatidylinositol-4-phosphate 3-kinase activity GO:0035005 IBA
    insulin receptor substrate binding GO:0043560 IEA
    ATP binding GO:0005524 IEA
Biological Process
    regulation of cell-matrix adhesion GO:0001952 IMP
    chemotaxis GO:0006935 TAS
    phospholipid metabolic process GO:0006644 TAS
    adaptive immune response GO:0002250 IBA
    cell migration GO:0016477 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    regulation of clathrin-mediated endocytosis GO:2000369 TAS
    embryonic cleavage GO:0040016 IEA
    activation of MAPK activity GO:0000187 TAS
    blood coagulation GO:0007596 TAS
    protein phosphorylation GO:0006468 IBA
    cellular calcium ion homeostasis GO:0006874 IEA
    T cell receptor signaling pathway GO:0050852 TAS
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 TAS
    platelet activation GO:0030168 TAS
    G-protein coupled receptor signaling pathway GO:0007186 TAS
    vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    positive regulation of autophagy GO:0010508 TAS
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    inflammatory response GO:0006954 IBA
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    platelet aggregation GO:0070527 TAS
    small molecule metabolic process GO:0044281 TAS
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    positive regulation of gene expression GO:0010628 IMP
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IBA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    innate immune response GO:0045087 TAS
    autophagy GO:0006914 IEA
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    leukocyte migration GO:0050900 TAS
    insulin receptor signaling pathway GO:0008286 TAS
    cell chemotaxis GO:0060326 IBA
    phosphatidylinositol phosphorylation GO:0046854 IBA
    phosphatidylinositol 3-kinase signaling GO:0014065 TAS
    signal transduction GO:0007165 NAS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    nucleus GO:0005634 IEA
    phosphatidylinositol 3-kinase complex GO:0005942 IBA
 Experiment description of studies that identified PIK3CB in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PIK3CB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRKCE  
Invivo Homo sapiens
2 PIK3R1 5295
Invivo Homo sapiens
Invitro Homo sapiens
3 MME 4311
Invitro Homo sapiens
Invivo Homo sapiens
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