Gene description for PIK3CB
Gene name	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Gene symbol	PIK3CB
Other names/aliases	P110BETA PI3K PI3KBETA PIK3C1
Species	Homo sapiens
Database cross references - PIK3CB
ExoCarta	ExoCarta_5291
Vesiclepedia	VP_5291
Entrez Gene	5291
HGNC	8976
MIM	602925
UniProt	P42338
PIK3CB identified in sEVs derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for PIK3CB

Molecular Function     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     1-phosphatidylinositol-3-kinase activity GO:0016303 IBA     1-phosphatidylinositol-3-kinase activity GO:0016303 TAS     1-phosphatidylinositol-4-phosphate 3-kinase activity GO:0035005 IBA     insulin receptor substrate binding GO:0043560 IEA     1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 IDA     1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 TAS     protein serine kinase activity GO:0106310 IDA Biological Process     endothelial cell proliferation GO:0001935 IEA     regulation of cell-matrix adhesion GO:0001952 IMP     response to ischemia GO:0002931 ISS     sphingosine-1-phosphate receptor signaling pathway GO:0003376 IMP     intracellular calcium ion homeostasis GO:0006874 IEA     endocytosis GO:0006897 IEA     autophagy GO:0006914 IEA     chemotaxis GO:0006935 TAS     homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA     signal transduction GO:0007165 NAS     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 TAS     G protein-coupled receptor signaling pathway GO:0007186 TAS     positive regulation of autophagy GO:0010508 TAS     positive regulation of endothelial cell migration GO:0010595 IGI     positive regulation of gene expression GO:0010628 IMP     cell migration GO:0016477 IBA     cell migration GO:0016477 TAS     platelet activation GO:0030168 TAS     positive regulation of neutrophil apoptotic process GO:0033031 IMP     positive regulation of Rac protein signal transduction GO:0035022 IGI     phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IBA     embryonic cleavage GO:0040016 IEA     natural killer cell mediated cytotoxicity GO:0042267 IDA     negative regulation of MAPK cascade GO:0043409 ISS     phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IBA     phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IGI     phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IMP     phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 ISS     phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 TAS     positive regulation of nitric oxide biosynthetic process GO:0045429 IMP     phosphatidylinositol phosphate biosynthetic process GO:0046854 IDA     phosphatidylinositol-mediated signaling GO:0048015 IBA     negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 IGI     angiogenesis involved in wound healing GO:0060055 IEA     platelet aggregation GO:0070527 TAS     negative regulation of vascular endothelial growth factor signaling pathway GO:1900747 IGI     negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway GO:1903298 IEA     negative regulation of sprouting angiogenesis GO:1903671 IMP     regulation of clathrin-dependent endocytosis GO:2000369 TAS Subcellular Localization     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     nucleolus GO:0005730 IDA     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IBA     phosphatidylinositol 3-kinase complex GO:0005942 IBA     phosphatidylinositol 3-kinase complex, class IA GO:0005943 IPI     phosphatidylinositol 3-kinase complex, class IA GO:0005943 NAS     midbody GO:0030496 IDA     intracellular membrane-bounded organelle GO:0043231 IDA